Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Hiroshi, Ishiba"'
Autor:
Kento Takeuchi, Kanji Yamaguchi, Yusuke Takahashi, Kota Yano, Shinya Okishio, Hiroshi Ishiba, Nozomi Tochiki, Seita Kataoka, Hideki Fujii, Naoto Iwai, Yuya Seko, Atsushi Umemura, Michihisa Moriguchi, Takeshi Okanoue, Yoshito Itoh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract GDF15 and FGF21, stress-responsive cytokines primarily secreted from the liver, are promising therapeutic targets for metabolic dysfunction-associated steatotic liver disease (MASLD). However, the interaction between GDF15 and FGF21 remains
Externí odkaz:
https://doaj.org/article/df294e94fab24a5399ce4312726c6372
Autor:
Miwa Kawanaka, Yoshihiro Kamada, Hirokazu Takahashi, Michihiro Iwaki, Ken Nishino, Wenli Zhao, Yuya Seko, Masato Yoneda, Yoshihito Kubotsu, Hideki Fujii, Yoshio Sumida, Hirofumi Kawamoto, Yoshito Itoh, Atsushi Nakajima, Takeshi Okanoue, Takumi Kawaguchi, Masafumi Ono, Hideyuki Hyogo, Yuichiro Eguchi, Takaomi Kessoku, Hiroshi Ishiba
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 8, Pp 1120-1128 (2024)
Background and Aims: Although numerous noninvasive diagnostic methods have been developed to predict liver fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD), they lack markers for predicting lobular inflammation, hepatocell
Externí odkaz:
https://doaj.org/article/1b400627ad7a488ebbac8f253a4b1865
Autor:
Hiroshi Ishiba, Yoshio Sumida, Yuya Seko, Saiyu Tanaka, Masato Yoneda, Hideyuki Hyogo, Masafumi Ono, Hideki Fujii, Yuichiro Eguchi, Yasuaki Suzuki, Masashi Yoneda, Hirokazu Takahashi, Takashi Nakahara, Kojiro Mori, Kazuyuki Kanemasa, Keiji Shimada, Kento Imajo, Kanji Yamaguchi, Takumi Kawaguchi, Atsushi Nakajima, Kazuaki Chayama, Toshihide Shima, Kazuma Fujimoto, Takeshi Okanoue, Yoshito Itoh, the Japan Study Group of NAFLD
Publikováno v:
Hepatology Communications, Vol 5, Iss 4, Pp 559-572 (2021)
This study aimed to examine whether the diagnostic accuracy of four noninvasive tests (NITs) for detecting advanced fibrosis in nonalcoholic fatty liver disease (NAFLD) is maintained or is inferior to with or without the presence of type 2 diabetes.
Externí odkaz:
https://doaj.org/article/c943576b74404d24865e8598197f9809
Autor:
Yu Liu, Yoshito Itoh, Kota Yano, Yuya Seko, Atsushi Umemura, Takeshi Okanoue, Michihisa Moriguchi, Seita Kataoka, Kanji Yamaguchi, Keiichiroh Okuda, Hiroshi Ishiba, Shinya Okishio, Hideki Fujii, Nozomi Tochiki, Aya Takahashi
Publikováno v:
Laboratory Investigation. 102:281-289
Fibroblast growth factor (FGF) 21 is an endocrine growth factor mainly secreted by the liver in response to a ketogenic diet and alcohol consumption. FGF21 signaling requires co-receptor β-klotho (KLB) co-acting with FGF receptors, which has pleiotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfcc8bf5fcb3e01c9d5df73a521b6ab
https://doi.org/10.1038/s41374-021-00680-9
https://doi.org/10.1038/s41374-021-00680-9
Publikováno v:
Journal of Gastroenterology and Hepatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee0a704b4c84fe3e5040ba703c741c45
https://doi.org/10.1111/jgh.16144
https://doi.org/10.1111/jgh.16144
Autor:
Yoshio Sumida, Masashi Yoneda, Yuya Seko, Hiroshi Ishiba, Tasuku Hara, Hidenori Toyoda, Satoshi Yasuda, Takashi Kumada, Hideki Hayashi, Takashi Kobayashi, Kento Imajo, Masato Yoneda, Toshifumi Tada, Takumi Kawaguchi, Yuichiro Eguchi, Satoshi Oeda, Hirokazu Takahashi, Eiichi Tomita, Takeshi Okanoue, Atsushi Nakajima, Japan Study Group of NAFLD (JSG-NAFLD)
Publikováno v:
Diagnostics, Vol 10, Iss 8, p 579 (2020)
Nonalcoholic fatty liver disease (NAFLD) is becoming the leading cause of hepatocellular carcinoma (HCC), liver-related mortality, and liver transplantation. There is sufficient epidemiological cohort data to recommend the surveillance of patients wi
Externí odkaz:
https://doaj.org/article/cacd5946ed1a4f939a52b47ae3c89a75
Autor:
Kota Yano, Hideki Fujii, Takeshi Okanoue, Michihisa Moriguchi, Junji Kamon, Kohichiroh Yasui, Aya Takahashi, Yu Liu, Keiichiroh Okuda, Daiki Takahashi, Atsushi Umemura, Yoshito Itoh, Seita Kataoka, Kanji Yamaguchi, Yusuke Ito, Nozomi Tochiki, Yuya Seko, Hiroshi Ishiba, Shinya Okishio
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
We explored the beneficial effects of GW7647, a peroxisome proliferator activated receptor α (PPARα) agonist, and metformin, an anti-diabetic drug on an advanced nonalcoholic steatohepatitis (NASH) model in rodents and investigated the possible mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af29c1bf499249cce45d8e0fa1892cc8
http://link.springer.com/article/10.1038/s41598-020-75805-z
http://link.springer.com/article/10.1038/s41598-020-75805-z
Autor:
Hisakazu Nakajima, Shin-ichi Horike, Kanji Yamaguchi, Yoshito Itoh, Kohichiroh Yasui, Michihisa Moriguchi, Wataru Aoi, Kazuki Kodo, Atsushi Umemura, Makiko Meguro-Horike, Satoru Sugimoto, Hiroyoshi Taketani, Taichiro Nishikawa, Yuya Seko, Hiroshi Ishiba
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12:1473-1492
Background and aims Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome, and its progression is associated with aging-associated impairment in metabolic homeostasis. Recently, energy metabolism in adipose tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e560c8959c14d75a988806a376f0d7e9
https://doi.org/10.2147/dmso.s214093
https://doi.org/10.2147/dmso.s214093
Autor:
Hiroshi Ishiba, Yoshio Sumida, Yuya Seko, Saiyu Tanaka, Masato Yoneda, Hideyuki Hyogo, Masafumi Ono, Hideki Fujii, Yuichiro Eguchi, Yasuaki Suzuki, Masashi Yoneda, Hirokazu Takahashi, Takashi Nakahara, Kojiro Mori, Kazuyuki Kanemasa, Keiji Shimada, Kento Imajo, Kanji Yamaguchi, Takumi Kawaguchi, Atsushi Nakajima, Kazuaki Chayama, Toshihide Shima, Kazuma Fujimoto, Takeshi Okanoue, Yoshito Itoh, the Japan Study Group of NAFLD
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 5, Iss 4, Pp 559-572 (2021)
Hepatology Communications, Vol 5, Iss 4, Pp 559-572 (2021)
This study aimed to examine whether the diagnostic accuracy of four noninvasive tests (NITs) for detecting advanced fibrosis in nonalcoholic fatty liver disease (NAFLD) is maintained or is inferior to with or without the presence of type 2 diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198aabb4250bf65b8f63ec51a0e7fa96
https://pubmed.ncbi.nlm.nih.gov/33860113
https://pubmed.ncbi.nlm.nih.gov/33860113
Autor:
Akira Okajima, Hidetaka Takashima, Hiroyuki Kimura, Toshihide Shima, Yo Takaharu, Masayasu Jo, Yasuyuki Nagao, Michihisa Moriguchi, Yoshito Itoh, Aya Takahashi, Hironori Mitsuyoshi, Hiroki Ishikawa, Akira Muramatsu, Hideki Fujii, Yasuhide Mitsumoto, Naomi Yoshinami, Hiroshi Ishiba, Masahiro Arai, Takeshi Okanoue, Atsushi Umemura, Tasuku Hara, Kanji Yamaguchi, Taichiro Nishikawa, Atsuhiro Morita, Tomoki Nakajima, Yuya Seko
Publikováno v:
Cancers
Volume 12
Issue 3
Cancers, Vol 12, Iss 3, p 754 (2020)
Volume 12
Issue 3
Cancers, Vol 12, Iss 3, p 754 (2020)
We investigated the association between early tumor shrinkage (ETS) and treatment outcome in patients with hepatocellular carcinoma treated with lenvatinib (LEN). A retrospective analysis was performed in 104 patients. ETS was defined as tumor shrink
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a0f89137637b1bda5dbd4cef3d66f3
http://europepmc.org/articles/PMC7140019
http://europepmc.org/articles/PMC7140019