Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Hiroshi, Hirota"'
Publikováno v:
Diabetes. 71
Background and Purpose: Poor perioperative glucose control in diabetes patients is associated with infectious adverse effects (AEs) . Radical radiotherapy (RT) for head and neck (H&N) cancer extensively destroys skin and the mucosa barrier function,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42a3633b31b0fb2a065852e32f26fe73
https://doi.org/10.2337/db22-1505-pub
https://doi.org/10.2337/db22-1505-pub
Autor:
Ryouichi Yoshimura, Fumihiko Tamamoto, Kei Ito, Hiroshi Hirota, Shun-ichiro Kageyama, Katsuyuki Karasawa
Publikováno v:
International Journal of Clinical Oncology. 25:978-983
The number of hemodialysis (HD) patients is increasing worldwide, and they are at a higher risk of cancer than the general population. Because HD patients are more likely to have inflammation, radiotherapy (RT)-induced adverse effects (AEs) are theor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3fc3729ba9fe81bd8c7b5226f68934
https://doi.org/10.1007/s10147-020-01621-0
https://doi.org/10.1007/s10147-020-01621-0
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 185:268-276
Comamonas testosteroni TA441 degrades steroid compounds via aromatization of the A-ring to produce 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid (a metabolite with C- and D-rings), which is presumed to be further degraded via β-oxidation. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82335c13e0889d1ace3e38ed38bd284d
https://doi.org/10.1016/j.jsbmb.2018.07.009
https://doi.org/10.1016/j.jsbmb.2018.07.009
Autor:
Toshiaki Hayashi, Hiroyuki Osada, Yuuki Furuyama, Hiromasa Kiyota, Hiroshi Hirota, Takashi Kamakura, Takayuki Motoyama, Toshihiko Nogawa
Publikováno v:
Bioscience, biotechnology, and biochemistry. 85(1)
Pyricularia oryzae is one of the most devastating plant pathogens in the world. This fungus produces several secondary metabolites including the phytotoxin pyriculols, which are classified into 2 types: aldehyde form (pyriculol and pyriculariol) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862b1f5f3cbed5b4343c28b34902e350
https://pubmed.ncbi.nlm.nih.gov/33577666
https://pubmed.ncbi.nlm.nih.gov/33577666
Autor:
Sho, Kato, Takayuki, Motoyama, Yushi, Futamura, Masakazu, Uramoto, Toshihiko, Nogawa, Toshiaki, Hayashi, Hiroshi, Hirota, Akira, Tanaka, Naoko, Takahashi-Ando, Takashi, Kamakura, Hiroyuki, Osada
Publikováno v:
Bioscience, biotechnology, and biochemistry. 84(6)
We identified the biosynthetic gene cluster for lucilactaene, a cell cycle inhibitor from a filamentous fungus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fce0ff912f3788b2ec5a257b1ad185d
https://pubmed.ncbi.nlm.nih.gov/32043422
https://pubmed.ncbi.nlm.nih.gov/32043422
Autor:
Takashi Kamakura, Hiroyuki Osada, Sho Kato, Masakazu Uramoto, Toshiaki Hayashi, Akira Tanaka, Yushi Futamura, Takayuki Motoyama, Toshihiko Nogawa, Naoko Takahashi-Ando, Hiroshi Hirota
We identified the biosynthetic gene cluster for lucilactaene, a cell cycle inhibitor from a filamentous fungus Fusarium sp. RK 97–94. The luc1 knockout strain accumulated demethylated analogs, indicating the involvement of Luc1 methyltransferase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a9d9f05f61b6367229e811075e819b
Autor:
Harumi Aono, Takayuki Motoyama, Hiroyuki Osada, Makoto Kawatani, Takeo Usui, Toshiaki Hayashi, Yoko Nagumo, Hiroshi Hirota
Publikováno v:
ChemistrySelect. 2:1533-1536
Terpendole E (TerE) is the first natural product that inhibits mitotic kinesin Eg5 (kinesin spindle protein). Recently, TerE is suggested to have a different binding site and/or inhibitory mechanism than other L5 loop-binding type Eg5 inhibitors. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef2220c694b9ed661cec71cf8d6bef0b
https://doi.org/10.1002/slct.201602015
https://doi.org/10.1002/slct.201602015
Publikováno v:
Applied and Environmental Microbiology. 85
Comamonas testosteroni TA441 degrades steroids via aromatization of the A ring, followed by degradation of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, mainly by β-oxidation. In this study, we revealed that 7β,9α-dihydroxy-17-oxo-1,2,3,4,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ab7ae3ac13a0ffd81bd13f81c45135
https://doi.org/10.1128/aem.01204-19
https://doi.org/10.1128/aem.01204-19
Publikováno v:
Applied and Environmental Microbiology. 84
Bacterial steroid degradation has been studied mainly with Rhodococcus equi (Nocardia restrictus) and Comamonas testosteroni as representative steroid degradation bacteria for more than 50 years. The primary purpose was to obtain materials for steroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8993278a77a215e006ae3d602a6890
https://doi.org/10.1128/aem.01324-18
https://doi.org/10.1128/aem.01324-18
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 185
Comamonas testosteroni TA441 degrades steroids via 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, which is presumed to be further degraded by β-oxidation. In the β-oxidation process, Coenzyme A (CoA)-ester of 9-oxo-1,2,3,4,5,6,10,19-octanor-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb71c96c362258d7df37f8bc8aaa73b7
https://pubmed.ncbi.nlm.nih.gov/30026063
https://pubmed.ncbi.nlm.nih.gov/30026063