Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Hiroshi, Hiai"'
Autor:
Tomoji Mashimo, Akiko Takizawa, Junya Kobayashi, Yayoi Kunihiro, Kazuto Yoshimi, Saeko Ishida, Koji Tanabe, Ami Yanagi, Asato Tachibana, Jun Hirose, Jun-ichiro Yomoda, Shiho Morimoto, Takashi Kuramoto, Birger Voigt, Takeshi Watanabe, Hiroshi Hiai, Chise Tateno, Kenshi Komatsu, Tadao Serikawa
Publikováno v:
Cell Reports, Vol 2, Iss 3, Pp 685-694 (2012)
Severe combined immunodeficiency (SCID) mice, the most widely used animal model of DNA-PKcs (Prkdc) deficiency, have contributed enormously to our understanding of immunodeficiency, lymphocyte development, and DNA-repair mechanisms, and they are idea
Externí odkaz:
https://doaj.org/article/d76e2b1b1e7545bf810b03de707531d5
Autor:
Jiro Kitamura, Munehiro Uemura, Mafumi Kurozumi, Makoto Sonobe, Toshiaki Manabe, Hiroshi Hiai, Hiroshi Date, Kazuo Kinoshita
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117986 (2015)
Activation-induced cytidine deaminase (AID) is an enzyme required for antibody diversification, and it causes DNA mutations and strand breaks. Constitutive AID expression in mice invariably caused lung lesions morphologically similar to human atypica
Externí odkaz:
https://doaj.org/article/f7b46aeda5434d8e8a61d2aa09c11b82
Autor:
Jiro Kitamura, Munehiro Uemura, Mafumi Kurozumi, Makoto Sonobe, Toshiaki Manabe, Hiroshi Hiai, Hiroshi Date, Kazuo Kinoshita
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136807 (2015)
Externí odkaz:
https://doaj.org/article/a65dc2facc6344c8a7005796135b2929
Autor:
Kenta Wada, Yoshibumi Matsushima, Tomoki Tada, Sayaka Hasegawa, Yo Obara, Yasuhiro Yoshizawa, Gou Takahashi, Hiroshi Hiai, Midori Shimanuki, Sari Suzuki, Junichi Saitou, Naoki Yamamoto, Masumi Ichikawa, Kei Watanabe, Yoshiaki Kikkawa
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111432 (2014)
Microphthalmia is a severe ocular disorder, and this condition is typically caused by mutations in transcription factors that are involved in eye development. Mice carrying mutations in these transcription factors would be useful tools for defining t
Externí odkaz:
https://doaj.org/article/06646f858edb4fc3a91f62cd2ce2d139
Autor:
Tomoji Mashimo, Akiko Takizawa, Birger Voigt, Kazuto Yoshimi, Hiroshi Hiai, Takashi Kuramoto, Tadao Serikawa
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8870 (2010)
BACKGROUND: Although the rat is extensively used as a laboratory model, the inability to utilize germ line-competent rat embryonic stem (ES) cells has been a major drawback for studies that aim to elucidate gene functions. Recently, zinc-finger nucle
Externí odkaz:
https://doaj.org/article/78a5092a4cf84d69bc26d693c9d63147
Autor:
Norio Yamamoto, Munehiro Uemura, Kazuo Kinoshita, Ryo Asato, Yukari Hattori, Yoshinobu Toda, Taichiro Nonaka, Motonobu Nakamura, Nagahiro Minato, Hiroshi Hiai, Kazuhisa Bessho
Publikováno v:
Journal of Clinical Investigation. 126:1367-1382
Most skin cancers develop as the result of UV light–induced DNA damage; however, a substantial number of cases appear to occur independently of UV damage. A causal link between UV-independent skin cancers and chronic inflammation has been suspected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f45cdafadca9161a4444eafd3182ac
https://doi.org/10.1172/jci81522
https://doi.org/10.1172/jci81522
Autor:
Tasuku Honjo, Herbert Pfister, Kazuhiko Koike, Maki Kobayashi, Tung Nguyen, Shunsuke Chikuma, Gian Paolo Marcuzzi, Jianliang Xu, Kazuo Kinoshita, Kyoji Moriya, Hiroshi Hiai
Publikováno v:
International Immunology. 26:397-406
Activation-induced cytidine deaminase (AID) not only promotes immune diversity by initiating somatic hypermutation and class switch recombination in immunoglobulin genes but also provokes genomic instability by introducing translocations and mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee19af30e5008ab36183f18f2be0adb6
https://doi.org/10.1093/intimm/dxu040
https://doi.org/10.1093/intimm/dxu040
Autor:
Hideki Yoshida, Hiroshi Hiai, Fumito Ozasa, Koichi Eguchi, Masamitsu Yamaguchi, Yasuhide Yoshioka, Kazushige Morishita
Publikováno v:
Cell Structure and Function. 39:113-124
The dedicator of cytokinesis (DOCK) family proteins that are conserved in a wide variety of species are known as DOCK1-DOCK11 in mammals. The Sponge (Spg) is a Drosophila counterpart to the mammalian DOCK3. Specific knockdown of spg by pannir-GAL4 or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e056835bc5a62f99125658efdcd56326
https://doi.org/10.1247/csf.14008
https://doi.org/10.1247/csf.14008
Autor:
Michiko Ehara, Motoo Kitano, Hayase Shisa, Masato Hirano, Jun-ichi Tanuma, Aiko Sugiyama, Hiroshi Hiai, Motohiko Nagayama, Hirohiko Suwa, Masahiro Sugimoto, Tomonari Muraki, Kouji Kawarada
Publikováno v:
Oncology Reports
Susceptibly to the induction of rat tongue cancer (TC) by oral 4-nitroquinoline 1-oxide (4NQO) exposure is a polygenic trait. Among several quantitative trait loci identified by crosses between TC-susceptible Dark Agouti (DA) rats and TC-resistant Wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c28a36a84293dd4cbf3639ac6bde147
http://europepmc.org/articles/PMC3868494
http://europepmc.org/articles/PMC3868494
Publikováno v:
Experimental Eye Research. 112:45-50
The Nakano cataract (NCT) is a recessive disorder in the mouse linked to the nct locus on chromosome 16. In this study, we positionally cloned the critical gene in the nct locus. Herein, we report that cataracts in the BALB/c-nct/nct mouse are caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447bd3927e1170d291f917db1cd3926d
https://doi.org/10.1016/j.exer.2013.04.005
https://doi.org/10.1016/j.exer.2013.04.005