Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hirosha Geekiyanage"'
Autor:
Shima Rayatpisheh, James A. Wohlschlegel, Robert H. Brown, Hirosha Geekiyanage, Victor R. Ambros
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance MicroRNAs (miRNAs) are abundant inside cells, where they regulate gene expression posttranscriptionally, but are also found in circulation as remarkably stable extracellular constituents of body fluids such as human blood plasma and cere
Autor:
Evanthia Galanis, Hirosha Geekiyanage
Publikováno v:
Molecular Oncology. 10:1387-1403
Oncolytic measles virus strains are currently being evaluated in several clinical trials, as a promising novel oncolytic platform. Poliovirus receptor‐related 4 (PVRL4) was recently identified as a potent measles virus (MV) receptor; however, its r
Publikováno v:
Neuroscience Letters. 554:121-125
Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by extracellular deposits of amyloid beta (Aβ) protein and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. Various studies suggest that the
Publikováno v:
Neurobiology of Aging. 34:2037-2051
The contribution of the autosomal dominant mutations to the etiology of familial Alzheimer’s disease (AD) is well characterized. However, the molecular mechanisms contributing to sporadic AD are less well understood. Increased ceramide levels have
Autor:
Jann N. Sarkaria, Brett L. Carlson, Cheyne Kurokawa, Cory Allen, Mark A. Schroeder, Ianko D. Iankov, Hirosha Geekiyanage, Katrina K. Bakken, A B D'Assoro, Bret Edward Buckley Friday, Evanthia Galanis, Jeffrey Ecsedy
Publikováno v:
Journal of neuro-oncology. 131(1)
Aurora A Kinase (AURKA), a member of the serine/threonine kinase family, plays a critical role in cell division, and it is widely overexpressed in a variety of tumors including glioblastoma (GBM). Alisertib (MLN8237) is an orally administered selecti
Publikováno v:
Experimental Neurology. 235:491-496
There is an urgent need to identify non-invasive biomarkers for the detection of sporadic Alzheimer’s disease (AD). We previously studied microRNAs (miRNAs) in AD autopsy brain samples and reported a connection between miR-137, -181c, -9, -29a/b an
Autor:
Courtney S. Malo, Jann N. Sarkaria, Aaron J. Johnson, Hirosha Geekiyanage, Evanthia Galanis, Mark A. Schroeder, Jayson Hardcastle, Fang Jin, Cheyne Kurokawa, Lisa D. Mills
Publikováno v:
Neuro-Oncology. :now179
Background Glioblastoma (GBM) is the most common primary malignant brain tumor and has a dismal prognosis. Measles virus (MV) therapy of GBM is a promising strategy due to preclinical efficacy, excellent clinical safety, and its ability to evoke anti
Autor:
Hirosha Geekiyanage, Evanthia Galanis
Publikováno v:
Molecular Therapy. 24:S27
Oncolytic measles virus (MV) strains represent a promising novel oncolytic platform that is currently evaluated in several clinical trials including glioblastoma. The recently identified MV receptor, poliovirus receptor-related 4 (PVRL4), has accumul
Autor:
Hirosha Geekiyanage, Christina Chan
Publikováno v:
Alzheimer's & Dementia. 8
Autor:
Christina Chan, Hirosha Geekiyanage
Publikováno v:
Alzheimer's & Dementia. 8