Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Hiroo Kuroki"'
Autor:
Tsutomu Anraku, Masaki Murata, Hiroo Kuroki, Akira Kazama, Yuko Shirono, Masayuki Tasaki, Vladimir Bilim, Yoshihiko Tomita
Publikováno v:
Journal of Personalized Medicine, Vol 14, Iss 7, p 704 (2024)
Despite significant advancements in systemic therapy for renal cell carcinoma (RCC), the prognosis for patients with metastatic RCC remains poor, as they are often incurable. Consequently, there is an urgent need for innovative therapeutic strategies
Externí odkaz:
https://doaj.org/article/83968521b1884b3fa8b0b1a0c4c0351c
Autor:
Yuko Shirono, Vladimir Bilim, Tsutomu Anraku, Hiroo Kuroki, Akira Kazama, Masaki Murata, Kaede Hiruma, Yoshihiko Tomita
Publikováno v:
Current Oncology, Vol 30, Iss 6, Pp 5350-5365 (2023)
Advanced bladder cancer (BC) (local invasive and/or metastatic) is not curable even with cytotoxic chemotherapy, immune checkpoint inhibitors, and targeted treatment. Targeting GSK-3β is a promising novel approach in advanced BC. The induction of au
Externí odkaz:
https://doaj.org/article/928668710b4b4b77a11f83773094fb54
Autor:
Akira Kazama, Vladimir Bilim, Masayuki Tasaki, Tsutomu Anraku, Hiroo Kuroki, Yuko Shirono, Masaki Murata, Kaede Hiruma, Yoshihiko Tomita
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Immune checkpoint inhibitors (ICI) have dramatically changed the treatment of metastatic renal cell carcinoma (mRCC). Although many studies have reported biomarkers as predicting the efficacy of ICI in mRCC, they remain controversial and hav
Externí odkaz:
https://doaj.org/article/21fdee8a2293495b97344d87f8c97253
Autor:
Hiroo Kuroki, Tsutomu Anraku, Akira Kazama, Vladimir Bilim, Masayuki Tasaki, Daniel Schmitt, Andrew P. Mazar, Francis J Giles, Andrey Ugolkov, Yoshihiko Tomita
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Abstract Glycogen synthase kinase-3 beta (GSK-3β), a serine/threonine kinase, has been identified as a potential therapeutic target in human bladder cancer. In the present study, we investigated the antitumor effect of a small molecule GSK-3β inhib
Externí odkaz:
https://doaj.org/article/1423d830529042219401ce10296db960
Publikováno v:
Journal of Personalized Medicine, Vol 12, Iss 10, p 1745 (2022)
Bladder cancer is the 10th most common cancer type in the world. There were more than 573,000 new cases of bladder cancer in 2020. It is the 13th most common cause of cancer death with an estimated more than 212,000 deaths worldwide. Low-grade non-mu
Externí odkaz:
https://doaj.org/article/5ee963303aaf4bc7b9109b4b6daf6add
Autor:
Sayaka Hoshino, Kenji Obara, Tatsuhiko Hoshii, Hiroo Kuroki, Kazuhiro Watanabe, Yoshihiko Tomita
Publikováno v:
Urology Case Reports, Vol 32, Iss , Pp 101253- (2020)
A 4-month-old girl presented us with genital ambiguity. The patient had a persistent urogenital sinus, posterior labial fusion with clitoromegaly. MRI reveals ovary-like mass in left inguinal region and right abdominal cavity. Uterus and vagina was a
Externí odkaz:
https://doaj.org/article/5420ffe1a794433698d8e633122b30d3
Publikováno v:
Urology Case Reports, Vol 14, Iss C, Pp 3-4 (2017)
A congenital megalourethra is an enlargement of the pendulous urethra without evidence of distal obstruction. A 1-month-old boy presented to us with complaint of weak stream, ballooning of the penis before and during voiding and post voiding dribblin
Externí odkaz:
https://doaj.org/article/b1d144a6907446e69f5105ef5c713407
Autor:
Tsutomu Anraku, Masaki Murata, Hiroo Kuroki, Akira Kazama, Yuko Shirono, Masayuki Tasaki, Vladimir Bilim, Yoshihiko Tomita
Background: Despite advances in systemic therapy for renal cell carcinoma (RCC), most metastatic RCCs remain incurable. Therefore, new therapeutic approaches are needed to further improve the outcome of RCC treatment. Methods: We treated cultured RCC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de4faf3f0a4536c3f7b86531c36e0370
https://doi.org/10.21203/rs.3.rs-2287954/v1
https://doi.org/10.21203/rs.3.rs-2287954/v1
Autor:
Hiroyuki Yamazaki, Ryo Maruyama, Tsutomu Anraku, Sayaka Hoshino, Kenji Obara, Kazutoshi Yamana, Tatsuhiko Hoshii, Hiroo Kuroki, Yoshihiko Tomita, Fumio Ishizaki
Publikováno v:
Urologia Internationalis. 104:386-390
Introduction: We aimed to assess the outcome of free tube graft urethroplasty for single-stage repair of hypospadias with chordee in children. Materials and Methods: We retrospectively evaluated a series of 56 patients (16 months to 9 years old, medi
Autor:
Yuko Shirono, Masaki Murata, Vladimir Bilim, Hiroo Kuroki, Tsutomu Anraku, Akira Kazama, Yoshihiko Tomita, Kazuhide Saito, Andrey Ugolkov
Publikováno v:
Oncology Reports
The selection of effective therapeutic agents is critical for improving the survival of patients with renal cell carcinoma (RCC). The aim of the present study was to develop an ex vivo drug testing assay using patient-derived tumor organoid (TO) cult