Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hironori Ohtsu"'
Autor:
Hironori Ohtsu, Tzuying Chiang, Zhiyan Xiao, Ching-Yuan Su, Eugene Chang, Kuo Hsiung Lee, Charles C. Y. Shih, Hideji Itokawa, Chawnshang Chang, Yi-Fen Lee, Shang Yi Chiu
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:5083-5090
Fifteen new diarylheptanoids were synthesized and evaluated for antagonistic activity against androgen receptor (AR)-mediated reporter gene transcription using DU145, PC-3, and LNCaP prostate cancer cell lines. Most compounds showed activity in a 5α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::696b353ec0c173150ca6d843fcd39711
https://doi.org/10.1016/j.bmc.2003.08.029
https://doi.org/10.1016/j.bmc.2003.08.029
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:1851-1857
Five conjugates (16–20) composed of a paclitaxel and a camptothecin derivative joined by an imine linkage were synthesized and evaluated as cytotoxic agents and as inhibitors of DNA topoisomerase I. All of the conjugates were potent inhibitors of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5535ce8f7251848d0512f56238bdd189
https://doi.org/10.1016/s0968-0896(03)00040-3
https://doi.org/10.1016/s0968-0896(03)00040-3
Autor:
Kenneth F. Bastow, Hideji Itokawa, Masahiro Nagai, Yuka Nakanishi, Junko Ishida, Hui Kang Wang, Yoko Tachibana, Hironori Ohtsu, Kuo Hsiung Lee
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:3481-3487
Fifty-eight curcumin analogues were prepared and evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Compound was the most potent analogue against several cell lines, including HOS (bone cancer) and 1A9 (breast cancer), wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::764e49b97d5a3e89041350dea9819222
https://doi.org/10.1016/s0968-0896(02)00249-3
https://doi.org/10.1016/s0968-0896(02)00249-3
Autor:
Chawnshang Chang, Eugene Chang, Charles C. Y. Shih, Yi-Fen Lee, Junko Ishida, Zhiyan Xiao, Hideji Itokawa, Masahiro Nagai, Hironori Ohtsu, Kuo Hsiung Lee, Ching-Yuan Su, Tzuying Chiang, Hui Kang Wang, Meng Yin Tsai
Publikováno v:
Journal of Medicinal Chemistry. 45:5037-5042
A number of curcumin analogues were prepared and evaluated as potential androgen receptor antagonists against two human prostate cancer cell lines, PC-3 and DU-145, in the presence of androgen receptor (AR) and androgen receptor coactivator, ARA70. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce1a970466034f2f6ef83ec1e814650
https://doi.org/10.1021/jm020200g
https://doi.org/10.1021/jm020200g
Autor:
Manabu Iwamoto, Akira Yoshitake, Toshifumi Minami, Hoyoku Nishino, Shunyo Matsunaga, Reiko Tanaka, Hironori Ohtsu, Harukuni Tokuda
Publikováno v:
Cancer Letters. 161:165-170
Seven labdane-type diterpenoids from the stem bark of Thuja standishii (Gord.) Carr. (Cupressaceae) and their analogues showed strong inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1326a597e30b00a385bc080b1a38d6
https://doi.org/10.1016/s0304-3835(00)00584-x
https://doi.org/10.1016/s0304-3835(00)00584-x
Autor:
Hoyoku Nishino, Shunyo Matsunaga, Harukuni Tokuda, Hironori Ohtsu, Reiko Tanaka, Yoshitaka Kinouchi
Publikováno v:
Journal of Natural Products. 63:817-820
A novel rearranged labdane-type diterpenoid, 19(4--3)abeo-8alpha, 13(S)-epoxylabda-4(18),14-diene (1), and two new abietane-type diterpenoids, 19-nor-abieta-4(18),8,11,13-tetraen-7-one (2) and 12-hydroxydehydroabietic acid (3) were isolated from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c51d7fdb6daed276128a3560a733754
https://doi.org/10.1021/np0000217
https://doi.org/10.1021/np0000217
Publikováno v:
Canadian Journal of Chemistry. 78:31-40
A new podocarpane diterpene, 7α,15-dihydroxypodocarp-8(14)-en-13-one (1) and eight new abietane diterpenes, abiet-8(14)-en-7α,13β,15,18-tetraol (2), 7α,13β,15-trihydroxyabiet-8(14)-en-18-oic acid (3), 13β,18-dihydroxyabiet-8(14)-en-7-one (4), 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbb5c1cbfafc4f6e495d3322c1a3d38d
https://doi.org/10.1139/v99-218
https://doi.org/10.1139/v99-218
Publikováno v:
Tetrahedron Letters. 40:6419-6422
Standishinal (1), a new irregular abietane-type diterpenoid, was isolated from the bark of Thuja standishii and the absolute stereostructure was established by 2D NMR and X-ray crystallographic analyses. It was found that treatment of 12-hydroxy-6,7-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c000307cecfed0c815bcd4e34149ef1c
https://doi.org/10.1016/s0040-4039(99)01191-0
https://doi.org/10.1016/s0040-4039(99)01191-0
Publikováno v:
Phytochemistry. 49:1761-1768
Two new triterpenes were isolated from the leaves of Larix kaempferi together with two known compounds, 24-methylenecycloartanone and 24-methylenecycloartanol. A new triterpene-triol, nine known compounds, n-alkyl trans-ferulates and trans-p-coumarat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2572774e2b90d7c88f014cf9dd7c1263
https://doi.org/10.1016/s0031-9422(98)00302-1
https://doi.org/10.1016/s0031-9422(98)00302-1
Publikováno v:
Phytochemistry. 46:1051-1057
The new diterpene acids were isolated from the leaves of Larix kaempferi, together with two known sesquiterpenes, (−)-α-cadinol and oplopanone, and 10 known diterpenes, larixol, dehydroabietinol, 7-oxo-dehydroabietinol, 7-oxodehydroabietic acid, 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::140a36e21310b74c1a6620b4de26e4d6
https://doi.org/10.1016/s0031-9422(97)84396-8
https://doi.org/10.1016/s0031-9422(97)84396-8