Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Hironori K. Nakamura"'
Peripheral blood metabolome predicts mood change-related activity in mouse model of bipolar disorder
Autor:
Hideo Hagihara, Tomoyasu Horikawa, Yasuhiro Irino, Hironori K. Nakamura, Juzoh Umemori, Hirotaka Shoji, Masaru Yoshida, Yukiyasu Kamitani, Tsuyoshi Miyakawa
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract Bipolar disorder is a major mental illness characterized by severe swings in mood and activity levels which occur with variable amplitude and frequency. Attempts have been made to identify mood states and biological features associated with
Externí odkaz:
https://doaj.org/article/c19c7f28881c48b5a8c16e1d74e5fb89
Autor:
Hideo Hagihara, Tomoyasu Horikawa, Hironori K. Nakamura, Juzoh Umemori, Hirotaka Shoji, Yukiyasu Kamitani, Tsuyoshi Miyakawa
Publikováno v:
Cell Reports, Vol 14, Iss 12, Pp 2784-2796 (2016)
Bipolar disorder, also known as manic-depressive illness, causes swings in mood and activity levels at irregular intervals. Such changes are difficult to predict, and their molecular basis remains unknown. Here, we use infradian (longer than a day) c
Externí odkaz:
https://doaj.org/article/bd10baaa23a441c9ae9753b89fe7b2d4
Publikováno v:
The Journal of Physical Chemistry B. 124:9977-9986
Cryptic sites are binding pockets that are transiently formed in an apo form or that are induced by ligand binding. The investigation of cryptic sites is crucial for drug discovery, since these sites are ubiquitous in disease-related human proteins,
Autor:
Hironori K. Nakamura, Koh Takeuchi, Tadaaki Mashimo, Yoshinori Wakabayashi, Takashi Kurosawa, Yoshifumi Fukunishi
Publikováno v:
Molecular Informatics
Membrane permeability is an important property of drugs in adsorption. Many prediction methods work well for small molecules, but the prediction of middle‐molecule permeability is still difficult. In the present study, we modified a classical perme
Peripheral blood metabolome predicts mood change-related activity in mouse model of bipolar disorder
Autor:
Hironori K. Nakamura, Hideo Hagihara, Tsuyoshi Miyakawa, Juzoh Umemori, Hirotaka Shoji, Tomoyasu Horikawa, Masaru Yoshida, Yukiyasu Kamitani, Yasuhiro Irino
Publikováno v:
Molecular Brain
Molecular Brain, Vol 12, Iss 1, Pp 1-10 (2019)
Molecular Brain, Vol 12, Iss 1, Pp 1-10 (2019)
Bipolar disorder is a major mental illness characterized by severe swings in mood and activity levels which occur with variable amplitude and frequency. Attempts have been made to identify mood states and biological features associated with mood chan
Autor:
Hironori K. Nakamura, Tomoyasu Horikawa, Tsuyoshi Miyakawa, Juzoh Umemori, Hideo Hagihara, Hirotaka Shoji, Yukiyasu Kamitani
Publikováno v:
Cell Reports, Vol 14, Iss 12, Pp 2784-2796 (2016)
SummaryBipolar disorder, also known as manic-depressive illness, causes swings in mood and activity levels at irregular intervals. Such changes are difficult to predict, and their molecular basis remains unknown. Here, we use infradian (longer than a
Autor:
Daisuke Kobayashi, Attayeb Mohsen, Masakazu Sekijima, Tomoki Ito, M. Michael Gromiha, Masahiro Mochizuki, Mika Sakamoto, Kenji Mizuguchi, Modong Tan, Hideaki Umeyama, Nobuaki Yasuo, Shuntaro Chiba, Shogo Suzuki, Takashi Ishida, Kazuyoshi Ikeda, Daisuke Kihara, Yoshitaka Moriwaki, Yutaka Akiyama, Reiji Teramoto, A. Mary Thangakani, Shintaro Minami, Vipul Gupta, Mitsuo Iwadate, Chioko Nagao, Takaaki Ichikawa, Kazuki Yamamoto, Masahito Ohue, Itsuo Nakane, Kei Yura, Tatsuya Okuno, George Chikenji, Masahiro Kawatani, Kun Yi Hsin, Sakurako Takashina, Takatsugu Hirokawa, Woong-Hee Shin, Devadasan Velmurugan, Hayase Hakariya, Chandrasekaran Ramakrishnan, Ryunosuke Yoshino, Hironori K. Nakamura, Philip Prathipati, Nobuaki Miura, Hiroaki Kitano, Sergey Zozulya, Mari Ito, Akiko Higuchi, Teruki Honma, Petro Borysko, Keita Oda, Anastasiia Gryniukova, Nanako Uchida, Kentaroh Kudoh
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds from a designated compound library contain
Autor:
Ryuki Ueno, Hironori K. Nakamura, Kazuo Kuwata, Kyoji Hagiwara, Shin nosuke Kanesashi, Yutaka Sasaki, Masaaki Suzuki, Kazunori D. Yamada, Kazufumi Shimizu, Hiroko Koyama, Yoko Aida, Atsushi Ueda
Publikováno v:
Microbes and Infection. 14:740-747
Influenza viruses have developed resistance to current drugs, creating a need for new antiviral targets and new drugs to treat influenza virus infections. In this study, computational and experimental screening of an extensive compound library identi
Autor:
Andrew C. Gill, Narinder Sanghera, Sonya Agarwal, Christian Ludwig, Hironori K. Nakamura, Eric Samain, Bruno E. Correia, Joana R.S. Correia, Boyan B. Bonev, Kazuo Kuwata, Teresa J. T. Pinheiro
Publikováno v:
Chemistry & Biology. 18:1422-1431
SummaryThe prion protein (PrP) resides in lipid rafts in vivo, and lipids modulate misfolding of the protein to infectious isoforms. Here we demonstrate that binding of recombinant PrP to model raft membranes requires the presence of ganglioside GM1.
Autor:
Zenichiro Kato, Kazuo Kuwata, Jack L. Strominger, Hironori K. Nakamura, Naoyuki Miyashita, Joel N. H. Stern, Naomi Kondo
Publikováno v:
Molecular Immunology. 48:314-320
The generation of T cell receptor (TCR) sequence diversity can produce ‘forbidden’ clones able to recognize self-antigens. Here, the structure of the complex between a myelin basic protein peptide (MBP85–99), human leukocyte antigen (HLA)-DR2 (