Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Hironori Harada"'
Autor:
Yoshihiro Hayashi, Yasushige Kamimura-Aoyagi, Sayuri Nishikawa, Rena Noka, Rika Iwata, Asami Iwabuchi, Yushin Watanabe, Natsumi Matsunuma, Kanako Yuki, Hiroki Kobayashi, Yuka Harada, Hironori Harada
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Most patients with advanced cancer develop cachexia, a multifactorial syndrome characterized by progressive skeletal muscle wasting. Despite its catastrophic impact on survival, the critical mediators responsible for cancer cachexia developm
Externí odkaz:
https://doaj.org/article/075a869b5d0542db8e1b818fd0098527
Autor:
Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Masayuki Yamashita, Shuhei Koide, Yaeko Nakajima-Takagi, Hiroko Kozuka-Hata, Masaaki Oyama, Takao Yogo, Tomohiro Yabushita, Ryoji Ito, Masaya Ueno, Atsushi Hirao, Kaoru Tohyama, Chao Li, Kimihito Cojin Kawabata, Kiyoshi Yamaguchi, Yoichi Furukawa, Hidetaka Kosako, Akihide Yoshimi, Susumu Goyama, Yasuhito Nannya, Seishi Ogawa, Karl Agger, Kristian Helin, Satoshi Yamazaki, Haruhiko Koseki, Noriko Doki, Yuka Harada, Hironori Harada, Atsuya Nishiyama, Makoto Nakanishi, Atsushi Iwama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA hypomethylating agents (HMAs) are used for the treatment of myeloid malignancies, although their therapeutic effects have been unsatisfactory. Here we show that CRISPR-Cas9 screening reveals that knockout of topoisomerase 1-binding argin
Externí odkaz:
https://doaj.org/article/d5c4ccd82b76400cb577a39dab027bde
Autor:
Tatsuya Konishi, Daichi Sadato, Takashi Toya, Chizuko Hirama, Yuya Kishida, Akihito Nagata, Yuta Yamada, Naoki Shingai, Hiroaki Shimizu, Yuho Najima, Takeshi Kobayashi, Kyoko Haraguchi, Yoshiki Okuyama, Hironori Harada, Kazuteru Ohashi, Yuka Harada, Noriko Doki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Young adults with myelodysplastic syndrome (MDS) are rare, and the clinical significance of driver mutations has not yet been analysed. We analysed the gene mutations and copy number alterations (CNAs) in younger MDS patients using next-gene
Externí odkaz:
https://doaj.org/article/01fa9889cec844f5afbe9de9cfd5bba6
Autor:
Shohei Takase, Takashi Hiroyama, Fumiyuki Shirai, Yuki Maemoto, Akiko Nakata, Mayumi Arata, Seiji Matsuoka, Takeshi Sonoda, Hideaki Niwa, Shin Sato, Takashi Umehara, Mikako Shirouzu, Yosuke Nishigaya, Tatsunobu Sumiya, Noriaki Hashimoto, Ryosuke Namie, Masaya Usui, Tomokazu Ohishi, Shun-ichi Ohba, Manabu Kawada, Yoshihiro Hayashi, Hironori Harada, Tokio Yamaguchi, Yoichi Shinkai, Yukio Nakamura, Minoru Yoshida, Akihiro Ito
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
This study describes RK-701, an inhibitor of histone methyltransferases G9a/GLP, as a promising therapeutic candidate for sickle cell disease and a universal role of BGLT3 lncRNA in fetal hemoglobin reactivation by chemical inducers including RK-701.
Externí odkaz:
https://doaj.org/article/854cca959e544001b639a7418e25c89f
Autor:
Naoki Ikeda, Hiroaki Kubota, Risa Suzuki, Mitsuki Morita, Ayana Yoshimura, Yuya Osada, Keigo Kishida, Daiki Kitamura, Ayaka Iwata, Satoshi Yotsumoto, Daisuke Kurotaki, Koutarou Nishimura, Akira Nishiyama, Tomohiko Tamura, Takashi Kamatani, Tatsuhiko Tsunoda, Miyako Murakawa, Yasuhiro Asahina, Yoshihiro Hayashi, Hironori Harada, Yuka Harada, Asumi Yokota, Hideyo Hirai, Takao Seki, Makoto Kuwahara, Masakatsu Yamashita, Shigeyuki Shichino, Masato Tanaka, Kenichi Asano
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112165- (2023)
Summary: Inflammatory stimuli cause a state of emergency myelopoiesis leading to neutrophil-like monocyte expansion. However, their function, the committed precursors, or growth factors remain elusive. In this study we find that Ym1+Ly6Chi monocytes,
Externí odkaz:
https://doaj.org/article/341ed34a2efa4c75818a16d64f9f1412
Autor:
Shuhei Kurosawa, Takashi Toya, Daichi Sadato, Tsunekazu Hishima, Chizuko Hirama, Yuho Najima, Takeshi Kobayashi, Kyoko Haraguchi, Yoshiki Okuyama, Keisuke Oboki, Hironori Harada, Hisashi Sakamaki, Kazuteru Ohashi, Yuka Harada, Noriko Doki
Publikováno v:
eJHaem, Vol 2, Iss 4, Pp 854-860 (2021)
Abstract A 58‐year‐old male was diagnosed with splenic B‐cell lymphoma/leukemia, unclassifiable (SPLL‐U). The lymphoma transformed into diffuse large B‐cell lymphoma (DLBCL), and multidrug chemotherapy and autologous stem cell transplantati
Externí odkaz:
https://doaj.org/article/e9ebcce2d74f445294d0b5092dc9f30d
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Hereditary myeloid malignancies, especially in adults or elderly persons, had been considered quite rare before the next-generation sequencing era; however, increased usage of clinical sequencing has revealed much higher prevalence of inherited myelo
Externí odkaz:
https://doaj.org/article/d8dc95b809a442c691b7cdf41465b418
Autor:
Kotoko Yamatani, Tomohiko Ai, Kaori Saito, Koya Suzuki, Atsushi Hori, Sonoko Kinjo, Kazuho Ikeo, Vivian Ruvolo, Weiguo Zhang, Po Yee Mak, Bogumil Kaczkowski, Hironori Harada, Kazuhiro Katayama, Yoshikazu Sugimoto, Jered Myslinski, Takashi Hato, Takashi Miida, Marina Konopleva, Yoshihide Hayashizaki, Bing Z. Carter, Yoko Tabe, Michael Andreeff
Publikováno v:
Translational Oncology, Vol 18, Iss , Pp 101354- (2022)
Tyrosine kinase inhibitors (TKIs) are established drugs in the therapy of FLT3-ITD mutated acute myeloid leukemia (AML). However, acquired mutations, such as D835 in the tyrosine kinase domain (FLT3-ITD/D835), can induce resistance to TKIs. A cap ana
Externí odkaz:
https://doaj.org/article/5f829a8f3d514045bac9ac8ddf376118
Autor:
Daichi Sadato, Chizuko Hirama, Ai Kaiho-Soma, Ayaka Yamaguchi, Hiroko Kogure, Sonomi Takakuwa, Mina Ogawa, Noriko Doki, Kazuteru Ohashi, Hironori Harada, Keisuke Oboki, Yuka Harada
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255257 (2021)
Gene abnormalities, including mutations and fusions, are important determinants in the molecular diagnosis of myeloid neoplasms. The use of bone marrow (BM) smears as a source of DNA and RNA for next-generation sequencing (NGS) enables molecular diag
Externí odkaz:
https://doaj.org/article/3173f9b171914b53b197c507cbe2a672
Autor:
Hiroko Sakurai, Yuka Harada, Yosuke Ogata, Yuki Kagiyama, Naoki Shingai, Noriko Doki, Kazuteru Ohashi, Toshio Kitamura, Norio Komatsu, Hironori Harada
Publikováno v:
Blood Advances, Vol 1, Iss 18, Pp 1382-1386 (2017)
Externí odkaz:
https://doaj.org/article/6fa33b68d586474f9453904d655aa49e