Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Hironori Fujiwara"'
Autor:
Ryota Araki, Hayato Tachioka, Ayami Kita, Hironori Fujiwara, Kazufumi Toume, Kinzo Matsumoto, Takeshi Yabe
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 11, Iss 6, Pp 513-519 (2021)
Kihito (KIT; Gui Pi Tang) is a traditional herbal medicine that is used for treatment of neuropsychiatric disorders such as depression, anxiety, neurosis and insomnia in China and Japan. Recently, it has also been shown that KIT improves cognitive dy
Externí odkaz:
https://doaj.org/article/a88ad20a4b7044bab850f22623f1b748
Publikováno v:
Journal of Pharmacological Sciences, Vol 141, Iss 3, Pp 111-118 (2019)
Post-weaning social isolation of laboratory animals is known to induce many behavioural and neurochemical abnormalities, which resemble neuropsychiatric disorders such as depression and anxiety. Therefore, they can help provide a suitable animal mode
Externí odkaz:
https://doaj.org/article/05f088e4790b472c99c96d3faa7d1124
Autor:
Hironori Fujiwara, Jun Yoshida, Dya Fita Dibwe, Suresh Awale, Haruka Hoshino, Hiroshi Kohama, Hiroyuki Arai, Yukitsuka Kudo, Kinzo Matsumoto
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 9, Iss 4, Pp 328-335 (2019)
Background and aim: The aging-dependent activation of glycogen synthase kinase-3β (GSK-3β) has been suggested to be important in the onset of dementia. To discover novel therapeutic Kampo medicines for dementia, we examined the effects of orengedok
Externí odkaz:
https://doaj.org/article/1c0f5162801d43bc8d33961d2ac3157e
Autor:
Yosuke Hiraki, Ryota Araki, Hironori Fujiwara, Yukio Ago, Tatsunori Tanaka, Kazufumi Toume, Kinzo Matsumoto, Takeshi Yabe
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 2, Pp 72-76 (2019)
Kamiuntanto (KUT; Jia Wei Wen Dan Tang in Pinyin) is a traditional Japanese Kampo medicine that is used to treat psychological dysfunction. However, the mechanisms of action of KUT are not understood. To investigate the mechanisms underlying the amel
Externí odkaz:
https://doaj.org/article/4beb4b86392d457d93fc61d61658c2c9
Autor:
Hironori Fujiwara, Ryohei Tsushima, Ryo Okada, Suresh Awale, Ryota Araki, Takeshi Yabe, Kinzo Matsumoto
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 8, Iss 1, Pp 81-88 (2018)
Social isolation (SI) mice exhibit behavioral abnormalities such as impairments of sociability- and attention-like behaviors, offering an animal model of neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD). This study
Externí odkaz:
https://doaj.org/article/ec221ec5d97e45bab09f66cc04c07bff
Autor:
Hironori Fujiwara, Yaoyu Han, Ken Ebihara, Suresh Awale, Ryota Araki, Takeshi Yabe, Kinzo Matsumoto
Publikováno v:
BMC Complementary and Alternative Medicine, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background Our previous studies demonstrated that post-weaning social isolation (ISO) in mice induces behavior abnormalities such as deficits of sociability- and attention-like behaviors. These deficits can be attenuated by methylphenidate (
Externí odkaz:
https://doaj.org/article/9c51f167f5ed4a5aaf5aae34ae03e8b2
Autor:
Qing-Yun Guo, Ken Ebihara, Takafumi Shimodaira, Hironori Fujiwara, Kazufumi Toume, Dya Fita Dibwe, Suresh Awale, Ryota Araki, Takeshi Yabe, Kinzo Matsumoto
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211266 (2019)
Dysfunctions in the GABAergic system are associated with the pathogenesis of autism spectrum disorder (ASD). However, the mechanisms by which GABAergic system dysfunctions induce the pathophysiology of ASD remain unclear. We previously demonstrated t
Externí odkaz:
https://doaj.org/article/b90fe8d48ae9479e803bea6ff07dcf84
Autor:
Daishu Mizuki, Zhao Qi, Ken Tanaka, Hironori Fujiwara, Tsutomu Ishikawa, Yoshihiro Higuchi, Kinzo Matsumoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 4, Pp 457-467 (2014)
This study investigated the effects of alcoholic extract of Butea superba (BS) on cognitive deficits and depression-related behavior using olfactory bulbectomized (OBX) mice and the underlying molecular mechanisms of its actions. OBX mice were treate
Externí odkaz:
https://doaj.org/article/e75e34f3610c48d291457168df8f5b35
Autor:
Kinzo Matsumoto, Qi Zhao, Yimin Niu, Hironori Fujiwara, Ken Tanaka, Sachie Sasaki-Hamada, Jun-Ichiro Oka
Publikováno v:
Journal of Pharmacological Sciences, Vol 122, Iss 4, Pp 257-269 (2013)
Cognitive deficits and behavioral and psychological symptoms of dementia (BPSD) are typical features of patients with dementia such as Alzheimer’s disease (AD), vascular dementia (VD), and other forms of senile dementia. Clinical evidence has demon
Externí odkaz:
https://doaj.org/article/15316cda8e924b4db98b0148337d05de
Autor:
Hironori Fujiwara, Ako Kogure, Masahiro Sakamoto, Tohru Yamakuni, Yoshihiro Mimaki, Kiyoshi Murata, Nobuyuki Hitomi, Kikuji Yamaguchi, Yasushi Ohizumi
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 4, Pp 384-387 (2011)
Abstract.: To prove the pharmacological actions of honeybee royal jelly (RJ) on the nervous system, we examined the effects of RJ on CRE-mediated transcription. RJ increased CRE-mediated transcription in PC12D cells. Moreover, CRE-mediated transcript
Externí odkaz:
https://doaj.org/article/c34fefb4d003423ca8fc49ccea499d19