Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hironobu Yasuno"'
Autor:
Hironobu Yasuno1 Hironobu.yasuno@takeda.com, Yasushi Masuda2, Harushige Ozaki1, Tomoya Sano1, Tadahiro Shinozawa1, Takeshi Watanabe1
Publikováno v:
Journal of Toxicologic Pathology. 2023, Vol. 36 Issue 4, p199-204. 6p.
Publikováno v:
Journal of Toxicologic Pathology. 36:145-149
Publikováno v:
Journal of Toxicologic Pathology. 2021, Vol. 34 Issue 3, p223-230. 8p.
Autor:
Tomoya Sano, Tadahiro Shinozawa, Takeshi Watanabe, Hironobu Yasuno, Yasushi Masuda, Masaaki Kakehi
Publikováno v:
Toxicological Sciences
Neurotoxicity is a principal concern in nonclinical drug development. However, standardized and universally accepted fluid biomarkers for evaluating neurotoxicity are lacking. Increasing clinical evidence supports the potential use of neurofilament l
Autor:
Shinji Iwasaki, Hironobu Yasuno, Derek M. Erion, Yumiko Okano Tamura, Masako Sasaki, Jun Sugama, Kazunobu Aoyama, Hiroaki Yashiro, Masanori Watanabe
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 379:280-289
Acetyl-CoA carboxylase (ACC) 1 and ACC2 are essential rate-limiting enzymes that synthesize malonyl-CoA (M-CoA) from acetyl-CoA. ACC1 is predominantly expressed in lipogenic tissues and regulates the de novo lipogenesis flux. It is upregulated in the
Publikováno v:
Journal of Toxicologic Pathology. 2020, Vol. 33 Issue 1, p25-28. 4p.
Publikováno v:
Journal of Toxicologic Pathology
There are limited data on the gene expression profiles of ion channels in the sinoatrial node (SAN) of dogs and monkeys. In this study, the messenger RNA (mRNA) expression profiles of various ion channels in the SAN of naive dogs and monkeys were exa
Publikováno v:
Journal of Toxicologic Pathology
A smooth white focus was macroscopically observed in the right ventricular endocardium in a 15-month-old male beagle from a 4-week oral gavage toxicity study. This lesion likely arose from myofibroblasts and was diagnosed as subendocardial nodular pr
Autor:
Hironobu Yasuno, Shuntarou Tsuchiya, Ayako Harada, Hiroshi Nagabukuro, Ryuichi Tozawa, Osamu Isono, Fumi Shimizu, Yuichiro Amano
Publikováno v:
Hepatology Research. 47:103-115
Aim: Experimental models of non-alcoholic steatohepatitis (NASH) are still required for understanding the pathophysiology of this disease. This study aimed to examine whether disease progression is accelerated by combining dyslipidemic genetic modifi
Autor:
Hironobu Yasuno, Yuki Takamatsu, Makoto Miyamoto, Kazuhiro Kuga, Yumiko Harada, Yumiko Miyamoto, Keiichiro Sato, Yumi Sakai, Fumi Shimizu
Publikováno v:
Journal of pharmacological and toxicological methods. 88(Pt 1)
In vivo phototoxicity studies are important to predict drug-induced phototoxicity in humans; however, a standard methodology has not established. To determine differences in sensitivity to drug-induced phototoxicity among various skin sites, we evalu