Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Hiromu Sugino"'
Autor:
Eliezer Masliah, Takato Takenouchi, Satoshi Inoue, Masaaki Waragai, Gilbert Ho, Shuei Sugama, Makoto Hashimoto, Hiromu Sugino
Publikováno v:
Journal of Alzheimer's Disease
Accumulating evidence suggests that the adiponectin (APN) paradox might be involved in promoting aging-associated chronic diseases such as Alzheimer’s disease (AD). In human brain, APN regulation of the evolvability of amyloidogenic proteins (APs),
Autor:
Shigenobu Matsumura, Makoto Sugiyama, Kazunari Sekiyama, Hitomi Takada, Masayuki Funaba, Akira Kurisaki, Kazuo Inoue, Ryo Satoh, Osamu Hashimoto, Seiichi Oyadomari, Chisato Suzuki, Hiroaki Oiwa, Norio Yamakawa, Hiromu Sugino, Satoru Doi, Masahiro Morita, Daichi Shindo, Hiroshi Itoi
Publikováno v:
Cell Reports. 25(5):1193-1203
Brown adipocyte activation or beige adipocyte emergence in white adipose tissue (WAT) increases energy expenditure, leading to a reduction in body fat mass and improved glucose metabolism. We found that activin E functions as a hepatokine that enhanc
Autor:
Eliezer Masliah, Makoto Hashimoto, Takato Takenouchi, Gilbert Ho, Hiromu Sugino, Yuka Shimizu, Masaaki Waragai, Shuei Sugama, Yoshiki Takamatsu
Publikováno v:
Drug Discov Today
Given the paradigm of anti-insulin resistance in therapies for metabolic syndrome, there has been considerable interest in adiponectin (APN), an adipocyte-derived sensitizer of insulin receptor signaling. In contrast to hypoadiponectinemia in metabol
Autor:
Hisashi Hirano, Kanako Watanabe-Susaki, Yuko Yamanaka, Makoto Asashima, Atsushi Intoh, Hitomi Takada, Hiromu Sugino, Megumi Kowno, Akira Kurisaki, Kei Enomoto
Publikováno v:
The Journal of Medical Investigation. 62(3-4):130-136
Mammalian pluripotent stem cells possess properties of self-renewal and pluripotency. These abilities are maintained by the strict regulation of pluripotent stem cell-specific transcription factor network and unique properties of chromatin in the ste
Autor:
Mio Nakanishi, Kanako Watanabe-Susaki, Yoshikazu Arai, Yasuhiro Seki, Makoto Asashima, Yoshiro Nakajima, Akira Kurisaki, Hiromu Sugino, Kunio Shiota
Publikováno v:
Proceedings of the National Academy of Sciences. 107:10926-10931
Transcription networks composed of various transcriptional factors specifically expressed in undifferentiated embryonic stem (ES) cells have been implicated in the regulation of pluripotency in ES cells. However, the molecular mechanisms responsible
Autor:
Rika Migishima, Satoshi Kida, Shiro Ikegami, Kunihiro Tsuchida, Masami Miura, Yoshihisa Hasegawa, Masao Masuda, Mitsutoshi Setou, Noriko Takashima, Hiroshi Ageta, Toshihiko Aosaki, Akiko Murayama, Kaoru Inokuchi, Minesuke Yokoyama, Toshiaki Hino, Hiromu Sugino
Publikováno v:
Learning & Memory. 17:176-185
A recent study has revealed that fear memory may be vulnerable following retrieval, and is then reconsolidated in a protein synthesis-dependent manner. However, little is known about the molecular mechanisms of these processes. Activin βA, a member
Autor:
Akira Kurisaki, Yuko Yamanaka, Hisashi Hirano, Hiroyuki Fukuda, Makoto Asashima, Hiromu Sugino, Atsushi Intoh
Publikováno v:
PROTEOMICS. 9:126-137
Embryonic stem cells (ESCs) are established from the inner cell mass of preimplantation embryos, are capable of self-renewal, and exhibit pluripotency. Given these unique properties, ESCs are expected to have therapeutic potential in regenerative med
Publikováno v:
Neuroscience. 151:1225-1235
Calcium entry into the postsynaptic neuron through N-methyl-D-aspartate-type glutamate receptors (NMDARs) triggers the induction of long-term potentiation (LTP), which is considered to contribute to synaptic plasticity and plays a critical role in be
Autor:
Yoko Shoji-Kasai, Hiromu Sugino, Kaoru Inokuchi, Kunihiro Tsuchida, Yoshihisa Hasegawa, Hiroshi Ageta
Publikováno v:
Journal of Cell Science. 120:3830-3837
Long-lasting modifications in synaptic transmission depend on de novo gene expression in neurons. The expression of activin, a member of the transforming growth factor β (TGF-β) superfamily, is upregulated during hippocampal long-term potentiation
Autor:
Tatsuya Murakami, Kunihiro Tsuchida, Hiromu Sugino, Kazuhiro Mori, Masashi Nakatani, Akira Kurisaki, Hitomi Kurose, Osamu Hashimoto, Sumihare Noji, Shoji Kagami, Hideyo Ohuchi, Yuka Takehara-Kasamatsu
Publikováno v:
The Journal of Medical Investigation. 54(3-4):276-288
Follistatin-related gene (FLRG) encodes a secretory glycoprotein that has characteristic cysteine-rich follistatin domains. FLRG protein binds to and neutralizes several transforming growth factor-beta (TGF-beta) superfamily members, including myosta