Zobrazeno 1 - 10
of 503
pro vyhledávání: '"Hiromu SUZUKI"'
Autor:
Fumika Okazaki, Akira Yorozu, Shohei Sekiguchi, Takeshi Niinuma, Reo Maruyama, Hiroshi Kitajima, Eiichiro Yamamoto, Kazuya Ishiguro, Mutsumi Toyota, Yui Hatanaka, Koyo Nishiyama, Kazuhiro Ogi, Masahiro Kai, Kenichi Takano, Shingo Ichimiya, Akihiro Miyazaki, Hiromu Suzuki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The tumor microenvironment plays a pivotal role in cancer development. We recently reported that in oral squamous cell carcinoma (OSCC), adipocyte enhancer-binding protein 1 (AEBP1) is abundantly expressed in cancer-associated fibroblasts (C
Externí odkaz:
https://doaj.org/article/cd3890c45c3748899b154b01802170fd
Autor:
Kazutaka Otsuji, Yoko Takahashi, Tomo Osako, Takayuki Kobayashi, Toshimi Takano, Sumito Saeki, Liying Yang, Satoko Baba, Kohei Kumegawa, Hiromu Suzuki, Tetsuo Noda, Kengo Takeuchi, Shinji Ohno, Takayuki Ueno, Reo Maruyama
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-15 (2024)
Abstract Metastasis is a complex process that remains poorly understood at the molecular levels. We profiled single-cell transcriptomic, genomic, and epigenomic changes associated with cancer cell progression, chemotherapy resistance, and metastasis
Externí odkaz:
https://doaj.org/article/179f0fdfd216418d9862aee1f1cbbaf0
Autor:
Hironori Aoki, Akira Takasawa, Eiichiro Yamamoto, Takeshi Niinuma, Hiro-o Yamano, Taku Harada, Toshiyuki Kubo, Akira Yorozu, Hiroshi Kitajima, Kazuya Ishiguro, Masahiro Kai, Akio Katanuma, Toshiya Shinohara, Hiroshi Nakase, Tamotsu Sugai, Makoto Osanai, Hiromu Suzuki
Publikováno v:
BMC Gastroenterology, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background Aberrant DNA methylation is prevalent in colorectal serrated lesions. We previously reported that the CpG island of SMOC1 is frequently methylated in traditional serrated adenomas (TSAs) and colorectal cancers (CRCs) but is rarely
Externí odkaz:
https://doaj.org/article/8486a115714241be8fcb8cc5abaacbd4
Autor:
Hiroshi Ohguro, Megumi Watanabe, Tatsuya Sato, Nami Nishikiori, Araya Umetsu, Megumi Higashide, Toshiyuki Yano, Hiromu Suzuki, Akihiro Miyazaki, Kohichi Takada, Hisashi Uhara, Masato Furuhashi, Fumihito Hikage
Publikováno v:
Cells, Vol 13, Iss 18, p 1549 (2024)
Cell culture methods are indispensable strategies for studies in biological sciences and for drug discovery and testing. Most cell cultures have been developed using two-dimensional (2D) culture methods, but three-dimensional (3D) culture techniques
Externí odkaz:
https://doaj.org/article/009e28d5818a4aa78f74be027397bc70
Autor:
Hiroshi Kitajima, Reo Maruyama, Takeshi Niinuma, Eiichiro Yamamoto, Akira Takasawa, Kumi Takasawa, Kazuya Ishiguro, Akihiro Tsuyada, Ryo Suzuki, Gota Sudo, Toshiyuki Kubo, Kei Mitsuhashi, Masashi Idogawa, Shoichiro Tange, Mutsumi Toyota, Ayano Yoshido, Kohei Kumegawa, Masahiro Kai, Kazuyoshi Yanagihara, Takashi Tokino, Makoto Osanai, Hiroshi Nakase, Hiromu Suzuki
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-14 (2023)
Abstract Long noncoding RNAs (lncRNAs) play pivotal roles in tumor development. To identify dysregulated lncRNAs in gastric cancer (GC), we analyzed genome-wide trimethylation of histone H3 lysine 4 (H3K4me3) to screen for transcriptionally active ln
Externí odkaz:
https://doaj.org/article/4c658e6fef904dec9cc5dcfec39e9a0e
Autor:
Yoshihiko Koike, Mitsumasa Osakabe, Ryo Sugimoto, Noriyuku Uesugi, Takayuki Matsumoto, Hiromu Suzuki, Naoki Yanagawa, Tamotsu Sugai
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract We performed comprehensive analyses of somatic copy number alterations (SCNAs) and gene expression profiles of gastric intramucosal neoplasia (IMN) using array‐based methods in 97 intestinal‐type IMNs, including 39 low‐grade dysplasias
Externí odkaz:
https://doaj.org/article/e091adcb3e1c43f9a09f4e67fa5378cc
Autor:
Akira Yorozu, Shohei Sekiguchi, Akira Takasawa, Fumika Okazaki, Takeshi Niinuma, Hiroshi Kitajima, Eiichiro Yamamoto, Masahiro Kai, Mutsumi Toyota, Yui Hatanaka, Koyo Nishiyama, Kazuhiro Ogi, Hironari Dehari, Kazufumi Obata, Makoto Kurose, Atsushi Kondo, Makoto Osanai, Akihiro Miyazaki, Kenichi Takano, Hiromu Suzuki
Publikováno v:
Cancer Medicine, Vol 12, Iss 5, Pp 5953-5963 (2023)
Abstract Background The CXCL12/CXCR4 axis plays a pivotal role in the progression of various malignancies, including oral squamous cell carcinoma (OSCC). In this study, we aimed to clarify the biological and clinical significance of CXCL12 in the tum
Externí odkaz:
https://doaj.org/article/438974de98e1444292b4d87dce47cdcb
Autor:
Shun Yamada, Mitsumasa Osakabe, Noriyuki Uesugi, Naoki Yanagawa, Takayuki Matsumoto, Hiromu Suzuki, Tamotsu Sugai
Publikováno v:
Cancer Medicine, Vol 12, Iss 4, Pp 4446-4454 (2023)
Abstract Background The objective of this study was to elucidate the association between neoplastic progression and somatic copy number alterations (SCNAs) occurring within the same colorectal cancer (CRC) tumor. Methods We investigated SCNAs to iden
Externí odkaz:
https://doaj.org/article/4046c282e4a040159959bf1161f1c44b
Genome‐wide analysis of mRNA and microRNA expression in colorectal cancer and adjacent normal mucosa
Autor:
Yuma Ito, Mitsumasa Osakabe, Takeshi Niinuma, Noriyuki Uesugi, Ryo Sugimoto, Naoki Yanagawa, Koki Otsuka, Akira Sasaki, Takayuki Matsumoto, Hiromu Suzuki, Tamotsu Sugai
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 4, Pp 313-326 (2022)
Abstract mRNA expression varies in human cancers. Such altered mRNA expression is negatively regulated by the expression of microRNAs (miRNAs), which play an important role in human tumorigenesis. According to this theory, inverse mRNA/miRNA expressi
Externí odkaz:
https://doaj.org/article/39bbf9054c6545f780908a93806d834b
Autor:
Go Asano, Katsuyuki Miyabe, Hiroyuki Kato, Michihiro Yoshida, Takeshi Sawada, Yasuyuki Okamoto, Hidenori Sahashi, Naoki Atsuta, Kenta Kachi, Akihisa Kato, Naruomi Jinno, Makoto Natsume, Yasuki Hori, Itaru Naitoh, Kazuki Hayashi, Yoichi Matsuo, Satoru Takahashi, Hiromu Suzuki, Hiromi Kataoka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract We aimed to assess some of the potential genetic pathways for cancer development from non-malignant intraductal papillary mucinous neoplasm (IPMN) by evaluating genetic mutations and methylation. In total, 46 dissected regions in 33 IPMN cas
Externí odkaz:
https://doaj.org/article/443a5b5710a04e9d83f87b7b724b79ff