Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hiromitsu Yoshimura"'
Autor:
Takayuki Sakai, Masanori Ito, Yibin Feng, Hiromitsu Yoshimura, Tadashi Nagamatsu, Yasushi Hirasawa
Publikováno v:
European Journal of Pharmacology. 672:159-168
Hyperglycemia and hyperlipidemia are considered critical to the development of diabetic nephropathy. The aim of this study is to clarify the effect of cholesterol on advanced-glycation-end-products and the mechanisms behind the advanced-glycation-end
Autor:
Masayoshi Ito, Hiromitsu Yoshimura, Yasushi Hirasawa, Katsuki Tsuritani, Tadashi Nagamatsu, Yusuke Kuwahara, Takayuki Sakai
Publikováno v:
Experimental and Molecular Pathology. 87:70-75
In the present study, we examined the effects of kynurenine metabolites on cultured mesangial cells (MCs) and demonstrated for the first time that they affect MC proliferation and gene expression. Anthranilic acid and 3-hydroxy- dl -kynurenine suppre
Autor:
Katsuki Tsuritani, Yasushi Hirasawa, Masayoshi Ito, Tadashi Nagamatsu, Hiromitsu Yoshimura, Yusuke Kuwahara, Aiko Ishii, Atsushi Nakamura
Publikováno v:
Life Sciences. 82:899-908
This study discusses the critical role of the metalloproteinase meprinbeta in the progression of glomerulonephritis. Using a microarray technique, the gene expression profiles in glomeruli isolated from high serum IgA (HIGA) mice with a purity of 97%
Autor:
Yoshiko Sakai, Saeko Uchida, Mari Aoki, Hiroshi Hara, Koichiro Shiokawa, Hiromitsu Yoshimura, Yumiko Toyoda, Shigeo Morimoto
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1520:45-53
By means of differential cDNA expression cloning, we earlier isolated a novel rat cDNA and its protein, named hepassocin, which is upregulated during liver regeneration. Using the rat cDNA as a probe, we have now isolated human hepassocin cDNA encodi
Autor:
Hiroshi Fukamachi, Hiromitsu Yoshimura, Yumiko Toyoda, Shigeo Morimoto, Hiroshi Hara, Koichiro Shiokawa, Kazunori Hanada, Mari Aoki, Saeko Uchida, Yoshiko Sakai
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492:31-44
By differential cDNA cloning coupled with Xenopus oocyte expression screening, we isolated a cDNA encoding a novel protein, termed ‘hepassocin’, the expression of which is upregulated in the regenerating rat liver. The cDNA contained a single ope
Autor:
Koko Sugawara, Shigeo Morimoto, Shigeru Murakami, Shiuji Saito, Akira Kawashima, Miyata Noriyuki, J S Yang, Hiromitsu Yoshimura, Masako Saito, Nannan Gao, Xingguo Zhang
Publikováno v:
Planta Medica. 69:673-675
The mechanism of action of the aerial parts of Clerodendranthus spicatus (Thunb.) C.Y. Wu, [syn. Orthosiphon aristatus (Blume) Miq,] a medicinal plant used in China to treat human renal disease, was investigated. The aqueous and methanol crude extrac
Autor:
Nobuko Futaki, Shingo Sekine, Hiromitsu Yoshimura, Akiko Mitani, Hisashi Adachi, Yoshikatsu Uematsu, Noriaki Shimizu
Publikováno v:
Protein expression and purification. 80(1)
We report the expression of a high level of human cyclooxygenase-1 (hCOX-1) in mammalian cells using a novel gene amplification method known as the IR/MAR gene amplification system. IR/MAR-plasmids contain a mammalian replication initiation region (I
Autor:
Hiromitsu Yoshimura, S. Tamaki, J. Fujiwara, Yoko Ikeda, M. Oishi, K. Nishimori, K. Kotoji, Kazunori Hanada
Publikováno v:
Plasmid. 28:115-122
It has previously been reported that composite DNAs derived from L factor, a polyoma-related mammalian plasmid, can be established in several mouse cell lines after transfection. Here, we report that the copy number of a plasmid composite DNA consist
Autor:
T. Kusano, Hiromitsu Yoshimura, S. Tamaki, Yoko Ikeda, Kazunori Hanada, Hiroshi Saito, Makoto Yoshimoto, Michio Oishi, Takashi Kohda
Publikováno v:
Nucleic acids research. 19(13)
L factor is a unique plasmid DNA which was originally discovered in a subclone (B822) of mouse L cells at a high copy number (more than 5,000 copies/cell). The presence of L factor caused no detectable abnormalities to the plasmid-bearing cells. We d
Autor:
Pam Drysdale, Jerzy Wasserman, Lucy A. Gallinger, Kazuo Ohuchi, Anne-Marie Ros, Masamichi Ishiguro, B. Huitfeldt, Nils Thyresson, Satoko Kiso, Patrick G. Holt, M.G. Baines, S. Leivers, Atsushi Kurihara, T. F. Huff, N.R. Ling, B. Skoogh, E.C. Olson, Susumu Tsurufuji, B.S. Wostmann, R.C. Godfrey, J.W. Coleman, Robbert Benner, Lars-Victor von Stedingk, Teruko Ishizaka, J J Haaijman, P. Rubin, T. Månsson, Shin Yoshino, Roger Henriksson, W. Hijmans, Shao-Qiu Gu, H. Ginsburg, A. Van Oudenaren, Corey Weiner, Te Piao King, Hiromitsu Yoshimura, S. Ahlstedt, Hirokazu Okudaira, J. Sjövall, J Slingerland-Teunissen, F. Maesen, Per E. Alm, Gunnar D. Bloom, H.F. Pross, Janet E. Batty
Publikováno v:
International Archives of Allergy and Immunology. 66:I-VI