Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hiromitsu Yokohama"'
Autor:
Hiromitsu Yokohama, Yoshito Kishi, Koichi Katayama, Daniel P. Rossignol, Jeffrey Rose, Tsutomu Kawata, Seiichi Kobayashi, Akira Ishibashi, J R Bristol, Isao Yamatsu, William J. Christ
Publikováno v:
British Journal of Pharmacology. 127:853-862
1. The major pathological responses to Gram-negative bacterial sepsis are triggered by endotoxin or lipopolysaccharide. As endotoxin is shed from the bacterial outer membrane, it induces immunological responses that lead to release of a variety of cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66f65f3c2bbf711e0765bf9812628768
https://doi.org/10.1038/sj.bjp.0702596
https://doi.org/10.1038/sj.bjp.0702596
Publikováno v:
Journal of Neurochemistry. 54:86-95
We recently reported that prostaglandin E2 (PGE2) stimulated phosphoinositide metabolism in cultured bovine adrenal chromaffin cells and that PGE2 and ouabain, an inhibitor of Na+,K+-ATPase, synergistically induced a gradual secretion of catecholamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b25afadb8bb76c4bf1936f5b8c889a
https://doi.org/10.1111/j.1471-4159.1990.tb13286.x
https://doi.org/10.1111/j.1471-4159.1990.tb13286.x
Autor:
Fumihiro Ozaki, Osamu Takenaka, Atsushi Kamada, Kenzo Muramoto, Tetsuya Kawahara, Masayoshi Ohkuro, Richard Clark, Kazuo Okano, Norihito Ohi, Toshihiko Kaneko, Seiichi Kobayashi, Hiromitsu Yokohama
Publikováno v:
Chemicalpharmaceutical bulletin. 52(6)
Novel piperidine carboxylic acid derivatives of 10H-pyrazino[2,3-b][1,4]benzothiazine were prepared and evaluated for their inhibitory activity on the upregulation of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). Replacement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a91e424018002b5b70aeac3a8110d5
https://pubmed.ncbi.nlm.nih.gov/15187387
https://pubmed.ncbi.nlm.nih.gov/15187387
Autor:
Fumihiro Ozaki, Osamu Takenaka, Kenzo Muramoto, Seiichi Kobayashi, Atsushi Kamada, Masayoshi Ohkuro, Toshihiko Kaneko, Hiroshi Akamatsu, Norihito Ohi, Richard Clark, Kazuo Okano, Tetsuya Kawahara, Hiromitsu Yokohama
Publikováno v:
Chemicalpharmaceutical bulletin. 50(7)
During a search for novel, orally-active inhibitors of upregulation of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), we found a new series of 10H-pyrazino[2,3-b][1,4]benzothiazine derivatives to be potent ICAM-1 inhibitors. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b4314b49f4704e954f65b861b671ab
https://pubmed.ncbi.nlm.nih.gov/12130850
https://pubmed.ncbi.nlm.nih.gov/12130850
Publikováno v:
Journal of neurochemistry. 56(1)
We have reported recently that prostaglandin E2 (PGE2) stimulated phosphoinositide metabolism in bovine adrenal chromaffin cells and that PGE2 and ouabain, an inhibitor of Na+, K(+)-ATPase, synergistically induced a gradual secretion of catecholamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a6d99c7b5e1afb8894b9483307bfdb
https://pubmed.ncbi.nlm.nih.gov/1898968
https://pubmed.ncbi.nlm.nih.gov/1898968
Publikováno v:
Chemical and Pharmaceutical Bulletin. 32:4023-4028
The synthesis of the 3-glucuronides of 20α-cortolone and their 20β-epimers is described. The cortol 20, 21-diacetates (3, 10) and cortolone 20, 21-diacetates (6, 12) were the key intermediates. Sodium borohydride reduction of the carbonyl group at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5130cbfd6633129bab72daa65f4fdb
https://doi.org/10.1248/cpb.32.4023
https://doi.org/10.1248/cpb.32.4023
Publikováno v:
Analytical Biochemistry. 150:26-31
High-performance liquid chromatographic methods for the determination of dolichols in tissues and plasma have been developed. The tissue concentration of dolichols was measured by high-performance liquid chromatography with uv detection and plasma le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71286eb732f342c9d11b11f3ea0aa2be
https://doi.org/10.1016/0003-2697(85)90437-3
https://doi.org/10.1016/0003-2697(85)90437-3
Autor:
Kazushige Sugama, Hideya Hayashi, Seiji Ito, Manabu Negishi, Teruo Tanaka, Hiromitsu Yokohama, Osamu Hayaishi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1011:75-80
In primary cultures of bovine adrenal medulla, chromaffin cells responded to prostaglandin (PG) E2 by stimulating phosphoinositide metabolism (Yokohama et al. (1988) J. Biol. Chem. 263, 1119-1122). In contrast, nonchromaffin cells were found to respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdad34790a9c42cb535fc0c5f4a19a7
https://doi.org/10.1016/0167-4889(89)90081-5
https://doi.org/10.1016/0167-4889(89)90081-5
Autor:
K Watanabe, Hideya Hayashi, T Tanaka, Seiji Ito, Manabu Negishi, Kawabe H, Hiromitsu Yokohama, Osamu Hayaishi
Publikováno v:
Prostaglandins. 33:517-530
In view of the recent finding that prostaglandin D2 is stereospecifically converted to 9 alpha, 11 beta-prostaglandin F2, an isomer of prostaglandin F2 alpha, a highly specific and sensitive radioimmunoassay for 9 alpha, 11 beta-prostaglandin F2 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106cef2d45b8f8e5a488498f902dff29
https://doi.org/10.1016/0090-6980(87)90275-9
https://doi.org/10.1016/0090-6980(87)90275-9
Publikováno v:
Chemical and Pharmaceutical Bulletin. 32:1359-1364
The synthesis of the 3-glucuronides of cortoic acids, metabolites of cortisol, is described. 20α-Cortolonic acid 3-glucuronide (11) and its 20β-epimer (12) were prepared starting from tetrahydrocortisone (1). The cortolonic acid 20-acetate methyl e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e3e6cd0295e83aa7890dbc2aaadf646
https://doi.org/10.1248/cpb.32.1359
https://doi.org/10.1248/cpb.32.1359