Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hiromitsu Yokohama"'
Autor:
Hiromitsu Yokohama, Yoshito Kishi, Koichi Katayama, Daniel P. Rossignol, Jeffrey Rose, Tsutomu Kawata, Seiichi Kobayashi, Akira Ishibashi, J R Bristol, Isao Yamatsu, William J. Christ
Publikováno v:
British Journal of Pharmacology. 127:853-862
1. The major pathological responses to Gram-negative bacterial sepsis are triggered by endotoxin or lipopolysaccharide. As endotoxin is shed from the bacterial outer membrane, it induces immunological responses that lead to release of a variety of cy
Publikováno v:
Journal of Neurochemistry. 54:86-95
We recently reported that prostaglandin E2 (PGE2) stimulated phosphoinositide metabolism in cultured bovine adrenal chromaffin cells and that PGE2 and ouabain, an inhibitor of Na+,K+-ATPase, synergistically induced a gradual secretion of catecholamin
Autor:
Fumihiro Ozaki, Osamu Takenaka, Atsushi Kamada, Kenzo Muramoto, Tetsuya Kawahara, Masayoshi Ohkuro, Richard Clark, Kazuo Okano, Norihito Ohi, Toshihiko Kaneko, Seiichi Kobayashi, Hiromitsu Yokohama
Publikováno v:
Chemicalpharmaceutical bulletin. 52(6)
Novel piperidine carboxylic acid derivatives of 10H-pyrazino[2,3-b][1,4]benzothiazine were prepared and evaluated for their inhibitory activity on the upregulation of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). Replacement
Autor:
Fumihiro Ozaki, Osamu Takenaka, Kenzo Muramoto, Seiichi Kobayashi, Atsushi Kamada, Masayoshi Ohkuro, Toshihiko Kaneko, Hiroshi Akamatsu, Norihito Ohi, Richard Clark, Kazuo Okano, Tetsuya Kawahara, Hiromitsu Yokohama
Publikováno v:
Chemicalpharmaceutical bulletin. 50(7)
During a search for novel, orally-active inhibitors of upregulation of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), we found a new series of 10H-pyrazino[2,3-b][1,4]benzothiazine derivatives to be potent ICAM-1 inhibitors. O
Publikováno v:
Journal of neurochemistry. 56(1)
We have reported recently that prostaglandin E2 (PGE2) stimulated phosphoinositide metabolism in bovine adrenal chromaffin cells and that PGE2 and ouabain, an inhibitor of Na+, K(+)-ATPase, synergistically induced a gradual secretion of catecholamine
Autor:
Kazushige Sugama, Hideya Hayashi, Seiji Ito, Manabu Negishi, Teruo Tanaka, Hiromitsu Yokohama, Osamu Hayaishi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1011:75-80
In primary cultures of bovine adrenal medulla, chromaffin cells responded to prostaglandin (PG) E2 by stimulating phosphoinositide metabolism (Yokohama et al. (1988) J. Biol. Chem. 263, 1119-1122). In contrast, nonchromaffin cells were found to respo
Autor:
K Watanabe, Hideya Hayashi, T Tanaka, Seiji Ito, Manabu Negishi, Kawabe H, Hiromitsu Yokohama, Osamu Hayaishi
Publikováno v:
Prostaglandins. 33:517-530
In view of the recent finding that prostaglandin D2 is stereospecifically converted to 9 alpha, 11 beta-prostaglandin F2, an isomer of prostaglandin F2 alpha, a highly specific and sensitive radioimmunoassay for 9 alpha, 11 beta-prostaglandin F2 was
Autor:
T Tanaka, Seiji Ito, T Katada, Manabu Negishi, Osamu Hayaishi, Hiromitsu Yokohama, H Hayashi, Michio Ui
Publikováno v:
Journal of Biological Chemistry. 262:12077-12084
Prostaglandin E2 (PGE2) specifically bound to 100,000 X g pellet prepared from bovine adrenal medulla, and [3H]PGE2-bound proteins were solubilized with 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic acid. The dissociation of bound [3H]PGE2
Publikováno v:
Chemical and Pharmaceutical Bulletin. 32:1359-1364
The synthesis of the 3-glucuronides of cortoic acids, metabolites of cortisol, is described. 20α-Cortolonic acid 3-glucuronide (11) and its 20β-epimer (12) were prepared starting from tetrahydrocortisone (1). The cortolonic acid 20-acetate methyl e
Publikováno v:
Biochemical Journal. 255:957-962
In bovine adrenal chromaffin cells, prostaglandin E2 (PGE2) stimulates the formation of inositol phosphates and Ca2+ mobilization through its specific receptor [Yokohama, Tanaka, Ito, Negishi, Hayashi & Hayaishi (1988) J. Biol. Chem. 263, 1119-1122].