Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hiromitsu Kunimi"'
Autor:
Deokho Lee, Yohei Tomita, Yukihiro Miwa, Hiromitsu Kunimi, Ayaka Nakai, Chiho Shoda, Kazuno Negishi, Toshihide Kurihara
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10140 (2024)
Hypoxia-inducible factors (HIFs) are transcriptional factors that function as strong regulators of oxygen homeostasis and cellular metabolisms. The maintenance of cellular oxygen levels is critical as either insufficient or excessive oxygen affects d
Externí odkaz:
https://doaj.org/article/c19d15c6073e4fec86023f7aff57fdb6
Autor:
Yusaku Katada, Hiromitsu Kunimi, Naho Serizawa, Deokho Lee, Kenta Kobayashi, Kazuno Negishi, Hideyuki Okano, Kenji F. Tanaka, Kazuo Tsubota, Toshihide Kurihara
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 1-13 (2023)
Ectopic induction of optogenetic actuators, such as channelrhodopsin, is a promising approach to restoring vision in the degenerating retina. However, the cell type-specific response of ectopic photoreception has not been well understood. There are l
Externí odkaz:
https://doaj.org/article/2eb99aaf89804103af13347c0cff9850
Autor:
Shin-ichi Ikeda, Toshihide Kurihara, Xiaoyan Jiang, Yukihiro Miwa, Deokho Lee, Naho Serizawa, Heonuk Jeong, Kiwako Mori, Yusaku Katada, Hiromitsu Kunimi, Nobuhiro Ozawa, Chiho Shoda, Mari Ibuki, Kazuno Negishi, Hidemasa Torii, Kazuo Tsubota
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
he underlying mechanism of myopic axial elongation of the eyes has long been unknown. Here, the authors show that endoplasmic reticulum stress in the sclera and its sensor proteins, PERK and ATF6, are involved in myopic axial elongation
Externí odkaz:
https://doaj.org/article/abe2d08ccb054189bebfa5d5b0ad66d5
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 10, Pp 2230-2231 (2022)
Externí odkaz:
https://doaj.org/article/15dd6ee631ea497fb1e9557288ee34fb
Publikováno v:
PeerJ, Vol 7, p e7849 (2019)
Purpose The therapeutic approach for retinal ganglion cell (RGC) degeneration has not been fully established. Recently, it has been reported that hypoxia-inducible factor (HIF) may be involved with retinal neurodegeneration. In this study, we investi
Externí odkaz:
https://doaj.org/article/cbc756618ec74bdabccaa48275be7080
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3171 (2019)
Neurodegeneration caused with retinal ischemia or high intraocular pressure is irreversible in general. We have focused on the role of hypoxia-inducible factor (HIF) in retinal homeostasis and revealed that HIF inhibition may be effective against ret
Externí odkaz:
https://doaj.org/article/dc0653d9747d43b68a11f3ce70325d49
Autor:
Mari Ibuki, Deokho Lee, Hiromitsu Kunimi, Chiho Shoda, Ayaka Nakai, Toshihide Kurihara, Yukihiro Miwa
Publikováno v:
The Keio Journal of Medicine. 71:1-12
The uncontrolled growth of blood vessels is a major pathological factor in human eye diseases that can result in blindness. This effect is termed ocular neovascularization and is seen in diabetic retinopathy, age-related macular degeneration, glaucom
Autor:
Hiromitsu Kunimi, Yusaku Katada, Deokho Lee, Kazuo Tsubota, Toshihide Kurihara, Mari Ibuki, Kazuno Negishi
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(8)
Retinal ischemia is a leading cause of irreversible blindness worldwide. Inner retinal dysfunction including loss of retinal ganglion cells is encountered in a number of retinal ischemic disorders. We previously reported administration of two differe
Autor:
Shin-ichi Ikeda, Toshihide Kurihara, Xiaoyan Jiang, Yukihiro Miwa, Deokho Lee, Naho Serizawa, Heonuk Jeong, Kiwako Mori, Yusaku Katada, Hiromitsu Kunimi, Nobuhiro Ozawa, Chiho Shoda, Mari Ibuki, Kazuno Negishi, Hidemasa Torii, Kazuo Tsubota
Publikováno v:
Nature communications. 13(1)
Axial length is the primary determinant of eye size, and it is elongated in myopia. However, the underlying mechanism of the onset and progression of axial elongation remain unclear. Here, we show that endoplasmic reticulum (ER) stress in sclera is a
Publikováno v:
Neural Regeneration Research. 17:2230