Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Hiromitsu Asashima"'
Autor:
Hiromitsu Asashima, Dongjoo Kim, Kaicheng Wang, Nikhil Lele, Nicholas C. Buitrago-Pocasangre, Rachel Lutz, Isabella Cruz, Khadir Raddassi, William E. Ruff, Michael K. Racke, JoDell E. Wilson, Tara S. Givens, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Steven H. Kleinstein, Ruth R. Montgomery, Albert C. Shaw, Fangyong Li, Rong Fan, David A. Hafler, Mary M. Tomayko, Erin E. Longbrake
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
BACKGROUND While B cell depletion is associated with attenuated antibody responses to SARS-CoV-2 mRNA vaccination, responses vary among individuals. Thus, elucidating the factors that affect immune responses after repeated vaccination is an important
Externí odkaz:
https://doaj.org/article/b06e7d12199f424e988db974eca28074
Autor:
Avraham Unterman, Tomokazu S. Sumida, Nima Nouri, Xiting Yan, Amy Y. Zhao, Victor Gasque, Jonas C. Schupp, Hiromitsu Asashima, Yunqing Liu, Carlos Cosme, Wenxuan Deng, Ming Chen, Micha Sam Brickman Raredon, Kenneth B. Hoehn, Guilin Wang, Zuoheng Wang, Giuseppe DeIuliis, Neal G. Ravindra, Ningshan Li, Christopher Castaldi, Patrick Wong, John Fournier, Santos Bermejo, Lokesh Sharma, Arnau Casanovas-Massana, Chantal B. F. Vogels, Anne L. Wyllie, Nathan D. Grubaugh, Anthony Melillo, Hailong Meng, Yan Stein, Maksym Minasyan, Subhasis Mohanty, William E. Ruff, Inessa Cohen, Khadir Raddassi, The Yale IMPACT Research Team, Laura E. Niklason, Albert I. Ko, Ruth R. Montgomery, Shelli F. Farhadian, Akiko Iwasaki, Albert C. Shaw, David van Dijk, Hongyu Zhao, Steven H. Kleinstein, David A. Hafler, Naftali Kaminski, Charles S. Dela Cruz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
SARS-CoV-2 infection can lead to progressive pathology in patients with COVID-19, but information for this disease progression is sparse. Here the authors use multi-omics approach to profile the immune responses of patients, assessing immune repertoi
Externí odkaz:
https://doaj.org/article/071dfec07b41418ab54ed9c36dc0d83e
Autor:
Masaru Shimizu, Yuya Kondo, Reona Tanimura, Kotona Furuyama, Masahiro Yokosawa, Hiromitsu Asashima, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract T-bet is a key transcription factor for the T helper 1 lineage and its expression level is negatively correlated to inflammation in patients with rheumatoid arthritis (RA). Our previous study using T-bet transgenic mice revealed over-express
Externí odkaz:
https://doaj.org/article/56b7d7675fa54ce8b1d120d5097ca7c5
Autor:
Hiromitsu Asashima, Pierre-Paul Axisa, Thi Hong Giang Pham, Erin E. Longbrake, William E. Ruff, Nikhil Lele, Inessa Cohen, Khadir Raddassi, Tomokazu S. Sumida, David A. Hafler
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)
B cell depletion in patients with relapsing-remitting multiple sclerosis (RRMS) markedly prevents new MRI-detected lesions and disease activity, suggesting the hypothesis that altered B cell function leads to the activation of T cells driving disease
Externí odkaz:
https://doaj.org/article/0c9d8420a9fe4098b16d60ae27757205
Autor:
Mana Iizuka-Koga, Hiromitsu Asashima, Miki Ando, Chen-Yi Lai, Shinji Mochizuki, Mahito Nakanishi, Toshinobu Nishimura, Hiroto Tsuboi, Tomoya Hirota, Hiroyuki Takahashi, Isao Matsumoto, Makoto Otsu, Takayuki Sumida
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1155-1163 (2017)
Although it is important to clarify the pathogenic functions of T cells in human samples, their examination is often limited due to difficulty in obtaining sufficient numbers of dendritic cells (DCs), used as antigen-presenting cells, especially in a
Externí odkaz:
https://doaj.org/article/12f69b208b4d43f28e2e556044abcc1e
Autor:
Haruka Miki, Hiroto Tsuboi, Shunta Kaneko, Hiroyuki Takahashi, Masahiro Yokosawa, Hiromitsu Asashima, Tomoya Hirota, Shinya Hagiwara, Naoto Umeda, Yuya Kondo, Bungo Nishimura, Masato Sugano, Isao Matsumoto, Takayuki Sumida
Publikováno v:
Allergology International, Vol 65, Iss 2, Pp 212-214 (2016)
Externí odkaz:
https://doaj.org/article/2b4c75e0d49e4683882750669deecde6
Publikováno v:
Allergology International, Vol 61, Iss 3, Pp 503-505 (2012)
Externí odkaz:
https://doaj.org/article/7c793721ae354776b015fbc88cd2cb89
Autor:
Haruka Miki, Hiroto Tsuboi, Fumina Kawashima, Toshiki Sugita, Taihei Nishiyama, Yuki Kuroda, Tomonori Sawabe, Nana Uematsu, Mayu Terasaki, Ayako Kitada, Fumika Honda, Ayako Ohyama, Mizuki Yagishita, Hiromitsu Asashima, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto
Publikováno v:
Internal Medicine; 2024, Vol. 63 Issue 5, p743-747, 5p
Autor:
Yang Liu, Marcello DiStasio, Graham Su, Hiromitsu Asashima, Archibald Enninful, Xiaoyu Qin, Yanxiang Deng, Jungmin Nam, Fu Gao, Pino Bordignon, Marco Cassano, Mary Tomayko, Mina Xu, Stephanie Halene, Joseph E. Craft, David Hafler, Rong Fan
Publikováno v:
Nature Biotechnology.
In this study, we extended co-indexing of transcriptomes and epitopes (CITE) to the spatial dimension and demonstrated high-plex protein and whole transcriptome co-mapping. We profiled 189 proteins and whole transcriptome in multiple mouse tissue typ
Autor:
Hiromitsu Asashima, Masaru Shimizu, Kotona Furuyama, Takayuki Sumida, Yuya Kondo, Masahiro Yokosawa, Hiroto Tsuboi, Reona Tanimura, Isao Matsumoto
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
T-bet is a key transcription factor for the T helper 1 lineage and its expression level is negatively correlated to inflammation in patients with rheumatoid arthritis (RA). Our previous study using T-bet transgenic mice revealed over-expression of T-