Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hiromitsu, Kawata"'
Autor:
Hiromitsu Kawata, Ayako Nishimoto, Nobuyuki Ishikura, Takao Houjo, Robert L. Vessella, Hitoshi Yoshino, Takashi Emura, Toshito Nakagawa, Kazutaka Tachibana, Haruhiko Sato, Miho Watanabe, Ryo Nakamura, Takuya Shiraishi, Masateru Ohta, Toshiaki Tsunenari, Yuko Aoki, Akie Honma, Eva Corey
Publikováno v:
International Journal of Oncology. 46:1560-1572
Resistance of prostate cancer to castration is currently an unavoidable problem. The major mechanisms underlying such resistance are androgen receptor (AR) overexpression, androgen-independent activation of AR, and AR mutation. To address this proble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e627101cf3300cee571ab61aa5f6c0ee
https://doi.org/10.3892/ijo.2015.2860
https://doi.org/10.3892/ijo.2015.2860
Autor:
Takuya Shiraishi, Ayako Nishimoto, Hitoshi Yoshino, Hiromitsu Kawata, Shinichi Arai, Haruhiko Sato, Kazutaka Tachibana, Toshito Nakagawa, Nobuyuki Ishikura, Ryo Nakamura
Publikováno v:
The Prostate. 71:1344-1356
BACKGROUND Castration-resistant prostate cancer (CRPC) is still dependent on androgen receptor (AR) signaling. We previously reported that a novel nonsteroidal AR pure antagonist, CH4933468, which is a thiohydantoin derivative with a sulfonamide side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96e9b7a016491ae90c43166f8992ac64
https://doi.org/10.1002/pros.21351
https://doi.org/10.1002/pros.21351
Autor:
Takuya Shiraishi, Ayako Nishimoto, Toshito Nakagawa, Akie Honma, Masateru Ohta, Hitoshi Yoshino, Kazutaka Tachibana, Nobuyuki Ishikura, Toshiaki Tsunenari, Kentaro Furumoto, Ryo Nakamura, Kazuya Kimura, Hiromitsu Kawata, Haruhiko Sato, Miho Watanabe, Noriyuki Takata, Takashi Emura
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:8150-8157
A series of 5,5-dimethylthiohydantoin derivatives were synthesized and evaluated for androgen receptor pure antagonistic activities for the treatment of castration-resistant prostate cancer. Since CH4933468, which we reported previously, had a proble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8d5bf575f9424ec05177698a77a811
https://doi.org/10.1016/j.bmc.2010.10.023
https://doi.org/10.1016/j.bmc.2010.10.023
Autor:
Hiromitsu Kawata, Hitoshi Yoshino, Haruhiko Sato, Nobuyuki Ishikura, Masateru Ohta, Etsuro Onuma, Takuya Shiraishi, Kyung-Yun Jung, Mitsuaki Nakamura, Masahiro Nagamuta, Kazutaka Tachibana, Toshito Nakagawa, Shinichi Arai, Koo-Hyeon Ahn
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:3159-3168
A series of 5,5-dimethylthiohydantoin derivatives were synthesized and evaluated for androgen receptor pure antagonistic activities for the treatment of hormone refractory prostate cancer. CH4933468 (32d) with a sulfonamide side chain not only exhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba02e5f233be169acfa3c16fe8e8218
https://doi.org/10.1016/j.bmc.2010.03.036
https://doi.org/10.1016/j.bmc.2010.03.036
Autor:
Yuko Aoki, Miho Watanabe, Toshiaki Tsunenari, Ayako Nishimoto, Hiromitsu Kawata, Nobuyuki Ishikura
Publikováno v:
The Prostate. 70:745-754
BACKGROUND Various hormone refractory prostate cancer cell models have been established with androgen depletion and have helped to clarify the mechanism for the transition into androgen-depletion independent status. However, the mechanism of bicaluta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25a5b35306986b4665d53a0c9a9d256
https://doi.org/10.1002/pros.21107
https://doi.org/10.1002/pros.21107
Publikováno v:
The Prostate. 70:457-466
BACKGROUND Hormone refractoriness is a lethal event for advanced prostate cancer patients, but the mechanisms of the disease are not well elucidated, especially for the so-called “outlaw” pathways of androgen receptor (AR)-dependent, androgen-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35262c1e5a3899d08a7470e3ce7f584e
https://doi.org/10.1002/pros.21079
https://doi.org/10.1002/pros.21079
Autor:
Hiromitsu, Kawata, Shinichi, Arai, Toshito, Nakagawa, Nobuyuki, Ishikura, Ayako, Nishimoto, Hitoshi, Yoshino, Takuya, Shiraishi, Kazutaka, Tachibana, Ryo, Nakamura, Haruhiko, Sato
Publikováno v:
The Prostate. 71(12)
Castration-resistant prostate cancer (CRPC) is still dependent on androgen receptor (AR) signaling. We previously reported that a novel nonsteroidal AR pure antagonist, CH4933468, which is a thiohydantoin derivative with a sulfonamide side chain, pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72a363b5fe17d4dd8e35d9807efec52a
https://pubmed.ncbi.nlm.nih.gov/21308717
https://pubmed.ncbi.nlm.nih.gov/21308717
Autor:
Hiromitsu, Kawata, Nobuyuki, Ishikura, Miho, Watanabe, Ayako, Nishimoto, Toshiaki, Tsunenari, Yuko, Aoki
Publikováno v:
The Prostate. 70(7)
Various hormone refractory prostate cancer cell models have been established with androgen depletion and have helped to clarify the mechanism for the transition into androgen-depletion independent status. However, the mechanism of bicalutamide resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e30cfb4d50a8d01f5c4a67cce236fdf6
https://pubmed.ncbi.nlm.nih.gov/20945499
https://pubmed.ncbi.nlm.nih.gov/20945499
Autor:
Nobuyuki, Ishikura, Hiromitsu, Kawata, Ayako, Nishimoto, Ryo, Nakamura, Nobuya, Ishii, Yuko, Aoki
Publikováno v:
The Prostate. 70(5)
Hormone refractoriness is a lethal event for advanced prostate cancer patients, but the mechanisms of the disease are not well elucidated, especially for the so-called "outlaw" pathways of androgen receptor (AR)-dependent, androgen-independent hormon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::413e8c6eebc1fcba958598dc08badedd
https://pubmed.ncbi.nlm.nih.gov/19902465
https://pubmed.ncbi.nlm.nih.gov/19902465
Autor:
Etsuro Onuma, Hiromitsu Kawata, Toshiaki Tsunenari, Takuya Shiraishi, Hitoshi Yoshino, Kenji Takanashi, Mitsuaki Nakamura, Kenji Taniguchi, Masahiro Nagamuta, Nobuyuki Ishikura, Toshito Nakagawa, Ikuhiro Imaoka, Masateru Ohta, Hidemi Saito, Kazutaka Tachibana, Haruhiko Sato
Publikováno v:
Chemicalpharmaceutical bulletin. 56(11)
The 3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethylthiohydantoin derivatives which have carboxy-terminal side chains were synthesized and their agonistic/antagonistic activities against androgen receptor (AR) measured. Among them, compound 13b showe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3543001fcbf1d2ef9dce6f168da28546
https://pubmed.ncbi.nlm.nih.gov/18981605
https://pubmed.ncbi.nlm.nih.gov/18981605