Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hiromichi Sugimoto"'
Autor:
Tatsuhiko Fujimoto, Kentaro Rikimaru, Koichiro Fukuda, Hiromichi Sugimoto, Kei Masuda, Norio Ohyabu, Yoshihiro Banno, Norihito Tokunaga, Tetsuji Kawamoto, Yoshihide Tomata, Yasumi Kumagai, Motoo Iida, Yoichi Nagano, Mariko Yoneyama-Hirozane, Yuji Shimizu, Katsunori Sasa, Takashi Ishikawa, Hiroshi Yukitake, Mitsuhiro Ito, Kazunobu Aoyama, Takahiro Matsumoto
Publikováno v:
ACS Medicinal Chemistry Letters. 13:457-462
TAK-925, a potent, selective, and brain-penetrant orexin 2 receptor (OX2R) agonist, [methyl (2
Autor:
Yoshiyuki Tsujihata, Hirohisa Miyashita, Kae Matsuda, Masahiro Kamaura, Shin-ichi Abe, Kenjiro Sato, Tomoyuki Odani, Osamu Kubo, Hiromichi Sugimoto, Toshiki Murata, Shinji Iwasaki, Naoyoshi Noguchi
Publikováno v:
Bioorganicmedicinal chemistry. 34
We previously identified a novel series of indolinylpyrimidine derivatives exemplified by 2 in Figure 1, which is an indoline based derivative, as potent GPR119 agonists. Despite the attractive potency of 2, this compound inhibited the human ether-a-
Autor:
Kentaro Rikimaru, Kenjiro Sato, Hirohisa Miyashita, Toshiki Murata, Tomoyuki Odani, Yoshiyuki Tsujihata, Hiroshi Imoto, Hiromichi Sugimoto, Nobuyuki Negoro, Masahiro Kamaura
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:1649-1666
GPR119 has emerged as an attractive target for anti-diabetic agents. We identified a structurally novel GPR119 agonist 22c that carries a 5-(methylsulfonyl)indoline motif as an early lead compound. To generate more potent compounds of this series, st
Autor:
Yuko Otani, Hiroaki Kurouchi, Tomohiko Ohwada, Kyoko Kawamoto, Hiromichi Sugimoto, Satoshi Nakamura
Publikováno v:
The Journal of Organic Chemistry. 77:9313-9328
Although cations with three heteroatoms, such as monoprotonated guanidine and urea, are stabilized by Y-shaped conjugation and such Y-conjugated cations are sufficiently basic to be further protonated (or protosolvated) to dications in strongly acid
Publikováno v:
Journal of the Japanese Society of Revegetation Technology. 36:322-325
Publikováno v:
Journal of the American Chemical Society. 132:807-815
The chemical features, such as substrate stability, product distribution, and substrate generality, and the reaction mechanism of Brønsted superacid-catalyzed cyclization reactions of aromatic ring-containing acetoacetates (beta-ketoesters) were exa
Autor:
Hiromi KOKETSU, Kenji TANAKA, Saburo TANAKA, Nobuhiko ASAHI, Kouki SUGIURA, Hiromichi SUGIMOTO
Publikováno v:
Journal of the Japanese Society of Revegetation Technology. 35:190-193
Publikováno v:
Journal of the Japanese Society of Revegetation Technology. 34:227-230
Publikováno v:
The Journal of Organic Chemistry. 72:10088-10095
Here, we describe mechanistic studies of the retro-Diels-Alder reaction of 4H-1,2-benzoxazines bearing various substituents on the benzene ring. 4H-1,2-Benzoxazines are very simple, but quite new, heterocyclic compounds that afford substituted o-quin
Publikováno v:
Advanced Synthesis & Catalysis. 349:669-679
o-Quinone methides (o-QMs) are highly reactive, short-lived intermediates, which have potential synthetic applicability. However, few studies on the generation of o-QMs bearing an electron-withdrawing group have been reported. Herein we present a gen