Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Hiromichi Shigyo"'
1
Development of specific Rho-kinase inhibitors and their clinical application
Autor: Masami Shiratsuchi, Takatoshi Ozawa, Hiroyoshi Hidaka, Masahiro Tamura, Hajime Yamada, Hiromichi Shigyo, Totsuka Junko, Hiroshi Nakao, Hideo Yoshizaki
Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1754:245-252
Hexahydro-1-(isoquinoline-5-sulfonyl)-1H-1,4-diazepine, HA-1077, is a known selective inhibitor of Rho-kinase. Although its IC(50) value against Rho-kinase is more than 10 times lower than those for kinases such as PKA, PKB, PKC, PKG, MLCK, CaMKII an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17002fa84743c5ff3491c710702af144
https://doi.org/10.1016/j.bbapap.2005.06.015
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2
Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1β) production
Autor: Hiromichi Shigyo, Tomoyuki Koshi, Taro Aoki, Tadaaki Ohgiya, Masao Ohkuchi, Takayuki Matsuda
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:2369-2372
New pyridazine derivatives were prepared, and their abilities to inhibit IL-1beta production were evaluated. Some compounds showed potent inhibitory activity against IL-1beta production in HL-60 cells stimulated with lipopolysaccharide (LPS). The syn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629f784bdca5e45f88a0249a29a90576
https://doi.org/10.1016/s0960-894x(01)00432-2
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3
A simple and efficient synthesis of 2,- 3-, or 4-(2-nitrophenyl)pyridine derivatives via palladium catalyzed ullmann cross-coupling reaction
Autor: Shimizu Noboru, Hiromichi Shigyo, Watanabe Koichiro, Takahiro Kitamura, Tomio Ohta, Takashi Yamaguchi
Publikováno v: Tetrahedron Letters. 34:3421-3424
The Ullmann cross-coupling reaction of halopyridines with 2-bromonitirobenzenes was successffully catalyzed by low valent palladium [Pd(PPh 3 ) 4 , PdCl 2 (PPh 3 ) 2 , PdCl 2 ] to afford (2-nitrophenyl)pyridine derivatives in good to excellent yield.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae79de26d1d1ec3d155226e98de3368a
https://doi.org/10.1016/s0040-4039(00)79172-6
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5
ChemInform Abstract: Synthesis and Bioactivities of Novel 5,6-Bis(4-methoxyphenyl)-2H-pyridazin-3-one Derivatives: Inhibitors of Interleukin-1 Beta (IL-1β) Production
Autor: Masao Ohkuchi, Hiromichi Shigyo, Taro Aoki, Tomoyuki Koshi, Takayuki Matsuda
Publikováno v: ChemInform. 32
New 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives were prepared, and their abilities to inhibit IL-1beta production were evaluated. Some compounds showed potent inhibitory activity against IL-1beta production in HL-60 cells stimulated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::697914e7283a2f05d22cfa74c73c7b73
https://doi.org/10.1002/chin.200152145
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6
Synthesis and bioactivities of novel 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives: inhibitors of interleukin-1 beta (IL-1beta) production
Autor: Takayuki Matsuda, Taro Aoki, Tomoyuki Koshi, Masao Ohkuchi, Hiromichi Shigyo
Publikováno v: Bioorganicmedicinal chemistry letters. 11(17)
New 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives were prepared, and their abilities to inhibit IL-1beta production were evaluated. Some compounds showed potent inhibitory activity against IL-1beta production in HL-60 cells stimulated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60d5e8d549f036dbeb48286305f8ad0
https://pubmed.ncbi.nlm.nih.gov/11527734
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7
Synthesis and antiarrhythmic activity of disubstituted phenylpyridine derivative
Autor: Takashi Yamaguchi, Hiromichi Shigyo, Kimiyuki Shibuya, Hiroyuki Sonoki, Yoshio Takahashi, Tomio Ohta, Seiichi Sato
Publikováno v: Chemicalpharmaceutical bulletin. 41(9)
A series of disubstituted phenylpyridine derivatives was synthesized and their antiarrhythmic effects against chloroform-induced ventricular arrhythmias in mice were examined. Among them, 2- and 3-[2-(3-aminobutyramido)-4-(2, 2, 2-trifluoroethoxy)phe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23864af433ca5fbab414fb201d80082d
https://pubmed.ncbi.nlm.nih.gov/8221971
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10
Studies on tertiary amine oxides. LI. Reactions of quinoline and isoquinoline N-oxides with propiolates and methacrylonitrile
Autor: Kazuhisa Funakoshi, Yoshiyuki Kuchino, Hiromichi Shigyo, Masatomo Hamana
Publikováno v: Chemical and Pharmaceutical Bulletin. 23:346-350
The 1, 3-dipolar cycloaddition between quinoline N-oxide (I) and methyl propiolate progressed in the presence of acetic anhydride or hydroquinone to afford methyl α-formyl-2-quinolineacetate (IIa). The reaction with ethyl propiolate in the presence
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9d76089ec726bef94347c70f17cdb0c
https://doi.org/10.1248/cpb.23.346
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