Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hiromichi Kosaka"'
Autor:
Miwa Watanabe, Hiromichi Kosaka, Masamori Sugawara, Michihiro Maemoto, Yoko Ono, Takeshi Uemori, Ryota Shizu, Kouichi Yoshinari
Publikováno v:
Cancer Medicine, Vol 12, Iss 8, Pp 9802-9814 (2023)
Abstract Objective EWS‐FLI1 is the most common oncogenic fusion protein in Ewing's sarcoma family tumors (ESFTs). DAX1, an orphan member of the nuclear receptor superfamily, is up‐regulated by EWS‐FLI1 and plays a key role in the transformed ph
Externí odkaz:
https://doaj.org/article/906d4085a139491bab6438486a342210
Autor:
Esther Giehl, Hiromichi Kosaka, Zuqiang Liu, Mathilde Feist, Udai S. Kammula, Michael T. Lotze, Congrong Ma, Zong Sheng Guo, David L. Bartlett
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Adoptive cell therapy (ACT) using autologous tumor infiltrating lymphocytes (TIL) achieves durable clinical benefit for patients from whom these cells can be derived in advanced metastatic melanoma but is limited in most solid tumors as a result of i
Externí odkaz:
https://doaj.org/article/525f6f107eda4fd488a555127d5b674c
Publikováno v:
PLoS Genetics, Vol 4, Iss 9, p e1000196 (2008)
During meiotic prophase, chromosomes display rapid movement, and their telomeres attach to the nuclear envelope and cluster to form a "chromosomal bouquet." Little is known about the roles of the chromosome movement and telomere clustering in this ph
Externí odkaz:
https://doaj.org/article/9954a86bf5ac4e10be109f202a8ec8e6
Autor:
Yozo Nishimura, Kenji Tamura, Kiyotoshi Mori, Norikazu Masuda, Hiromichi Kosaka, Shigehira Saji, Ayumi Kaneda, Hiroji Iwata
Publikováno v:
Cancer Research. 80:2913-2913
Objective: Entinostat (KHK2375 also known as MS-275, SNDX-275 and ZN244894), a synthetic benzamide derivative, is a class I selective histone deacetylase inhibitor. Entinostat increases the acetylation of histone and non-histone proteins. Change of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::010d04dde0ea2237d85115b2bee032f4
https://doi.org/10.1158/1538-7445.am2020-2913
https://doi.org/10.1158/1538-7445.am2020-2913
Autor:
Hideaki Kusaka, Hiromichi Kosaka, Nobuyuki Yoda, Sasaki Katsutoshi, Masahiro Matsubara, Tetsuya Kitayama, Kazunori Hirayama
Publikováno v:
European Journal of Pharmacology. 635:49-55
Aldosterone-induced activation of mineralocorticoid receptor, a member of the nuclear receptor family, results in increased tissue damage such as vascular inflammation and cardiac and perivascular fibrosis. Benidipine, a long-lasting dihydropyridine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278cca442956b4a62c7347a521386000
https://doi.org/10.1016/j.ejphar.2010.03.018
https://doi.org/10.1016/j.ejphar.2010.03.018
Publikováno v:
Nucleic Acids Research
MutS homologues are highly conserved enzymes engaged in DNA mismatch repair (MMR), meiotic recombination and other DNA modifications. Genome sequencing projects have revealed that bacteria and plants possess a MutS homologue, MutS2. MutS2 lacks the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02ec74d3b266785f30a9032be9e380d
https://doi.org/10.1093/nar/gkl735
https://doi.org/10.1093/nar/gkl735
Autor:
Mitsuo Satoh, Kazuyasu Nakamura, Kazuhiro Masuda, Katsuaki Usami, Kazumasa Hasegawa, Hiroe Toki, Hironori Kawai, Akiko Furuya, Toshio Ota, Norihiko Shiraishi, Yuka Sasaki, Hiromichi Kosaka
Publikováno v:
Biochemical and biophysical research communications. 394(3)
LGR5 is an orphan G-protein-coupled receptor (GPCR) that is expressed on the cell surface membrane. LGR5 is reported to be overexpressed in colon, liver, and ovary tumor compared to normal tissue. However, a specific ligand for LGR5 has not yet been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f8d79be3f0552dc49645b0599c0f11
https://pubmed.ncbi.nlm.nih.gov/20197059
https://pubmed.ncbi.nlm.nih.gov/20197059
Publikováno v:
Journal of molecular biology. 373(4)
Uracil-DNA glycosylase (UDG) removes uracil generated by the deamination of cytosine or misincorporation of deoxyuridine monophosphate. Within the UDG superfamily, a fifth UDG family lacks a polar residue in the active-site motif, which mediates the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf59160e748a87557ee0f1f12bb89d4
https://pubmed.ncbi.nlm.nih.gov/17870091
https://pubmed.ncbi.nlm.nih.gov/17870091
Autor:
Hiromichi Kosaka, Yoshisuke Nakasato, Yasuo Watanabe, Miwa Watanabe, Yoko Ono, Masahiro Matsubara, Ryuichiro Nakai, Masamori Sugawara, Michihiro Maemoto
Publikováno v:
Molecular Cancer Therapeutics. 14:A155-A155
Background: Ewing's sarcoma family of tumors (ESFTs) are characterized by chromosomal translocations that fuses EWSR1 gene and other types of ETS family genes. Among them, EWS-FLI1 is the most common transcriptional factor which regulates many genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f605899a8c9aaa32c4303927702a3e12
https://doi.org/10.1158/1535-7163.targ-15-a155
https://doi.org/10.1158/1535-7163.targ-15-a155
Publikováno v:
PLoS Genetics, Vol 4, Iss 9, p e1000196 (2008)
During meiotic prophase, chromosomes display rapid movement, and their telomeres attach to the nuclear envelope and cluster to form a "chromosomal bouquet." Little is known about the roles of the chromosome movement and telomere clustering in this ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e9bcfb67a5aebab55ce1e853be325a
https://doi.org/10.1371/journal.pgen.1000196
https://doi.org/10.1371/journal.pgen.1000196