Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Hiromichi Kimura"'
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Background Human resource management may become complex for community pharmacists owing to recent changes in work volume and content. Few studies have examined job satisfaction, well-being, and quality of work life (QWL) among community phar
Externí odkaz:
https://doaj.org/article/88ad21ea2ad84a17a138eb908b0f60ee
Publikováno v:
Exploratory Research in Clinical and Social Pharmacy, Vol 14, Iss , Pp 100458- (2024)
Background: In Japan, pharmacists' role has drastically changed in recent years. However, previous studies have not performed internal marketing analysis for Japanese community pharmacists so that they improve the quality of work life (QWL) and be sa
Externí odkaz:
https://doaj.org/article/1b4af6278ed24ac0b8ccb2bfc3d54df5
The sonic hedgehog (Shh) pathway is activated in ∼30% of human medulloblastoma resulting in increased expression of downstream target genes. In about half of these cases, this has been shown to be a consequence of mutations in regulatory genes with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7a4acba7a00c9add39c8d85fe408907
https://doi.org/10.1158/0008-5472.c.6496787
https://doi.org/10.1158/0008-5472.c.6496787
Supplementary Figure 1 and Tables 1-2 from Medulloblastomas Derived from Cxcr6 Mutant Mice Respond to Treatment with a Smoothened Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d29821592dc3e881a98673d97982db4
https://doi.org/10.1158/0008-5472.22371410
https://doi.org/10.1158/0008-5472.22371410
Background: Human resource management may be difficult for community pharmacists because of recent drastic changes in work volume and content. In Japan, few studies have been conducted on job satisfaction, well-being, and quality of work life (QWL) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb07e7e3cb52142b04b15feb96fd1ee8
https://doi.org/10.21203/rs.3.rs-2497913/v1
https://doi.org/10.21203/rs.3.rs-2497913/v1
Autor:
Masanori Okaniwa, Daisuke Morishita, Michael G. Klein, Yuta Tanaka, Bunnai Saito, Shigemitsu Matsumoto, Shinichi Imamura, Hiromichi Kimura, Geza Ambrus-Aikelin, Noriko Uchiyama, Osamu Kurasawa, Akihiro Yokota
Publikováno v:
ACS Medicinal Chemistry Letters
Deoxyhypusine synthase (DHPS) is the primary enzyme responsible for the hypusine modification and, thereby, activation of the eukaryotic translation initiation factor 5A (eIF5A), which is key in regulating the protein translation processes associated
Autor:
Masanori Okaniwa, Geza Ambrus-Aikelin, Shigemitsu Matsumoto, Yuta Tanaka, Akihiro Yokota, Koji Ono, Kazumasa Ogawa, Daisuke Morishita, Satoshi Kitazawa, Osamu Kurasawa, Michael G. Klein, Shinichi Imamura, Hiromichi Kimura, Noriko Uchiyama, Bunnai Saito
Publikováno v:
Journal of Medicinal Chemistry. 63:3215-3226
Deoxyhypusine synthase (DHPS) utilizes spermidine and NAD as cofactors to incorporate a hypusine modification into the eukaryotic translation initiation factor 5A (eIF5A). Hypusine is essential for eIF5A activation, which, in turn, plays a key role i
Autor:
Natsuko, Tabata, Mai, Tsukada, Kozue, Kubo, Yuri, Inoue, Reiko, Miroku, Fumihiko, Odashima, Koichiro, Shiratori, Takashi, Sekiya, Shintaro, Sengoku, Hideaki, Shiroyama, Hiromichi, Kimura
Publikováno v:
International Journal of Environmental Research and Public Health, Vol 19, Iss 1254, p 1254 (2022)
International Journal of Environmental Research and Public Health; Volume 19; Issue 3; Pages: 1254
International Journal of Environmental Research and Public Health; Volume 19; Issue 3; Pages: 1254
The establishment and implementation of a healthy lifestyle is fundamental to public health and is an important issue for working-aged people, as it affects not only them but also the future generations. However, due to the COVID-19 pandemic and asso
Autor:
Samuel Aparicio, Tomohiro Kawamoto, Yoshihiro Ishibashi, Atsushi Nakanishi, Hiromichi Kimura, Daisuke Morishita, Misa Iwatani-Yoshihara, Takashi Ito, Hideyuki Oki, Yasuhiro Imaeda, Toshio Tanaka, Masahiro Ito
Publikováno v:
ACS Chemical Biology. 12:1760-1768
Eukaryotic initiation factor 4A-3 (eIF4A3) is an Asp-Glu-Ala-Asp (DEAD) box-family adenosine triphosphate (ATP)-dependent RNA helicase. Subtypes eIF4A1 and eIF4A2 are required for translation initiation, but eIF4A3 participates in the exon junction c
Autor:
Akito Nakamura, Hiromichi Kimura
Publikováno v:
Biochemical and Biophysical Research Communications. 485:484-491
General control nonderepressible 2 (GCN2) is activated by the accumulation of uncharged tRNA in response to amino acid shortage and regulates amino acid starvation response in the cytosol. Here we report the nucleolar localization of GCN2 and the ass