Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Hiromichi Dansako"'
Autor:
Wenhao Zhou, Shusuke Kawashima, Takamasa Ishino, Katsushige Kawase, Youki Ueda, Kazuo Yamashita, Tomofumi Watanabe, Masahito Kawazu, Hiromichi Dansako, Yutaka Suzuki, Hiroyoshi Nishikawa, Takashi Inozume, Joji Nagasaki, Yosuke Togashi
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113797- (2024)
Summary: Immune checkpoint inhibitors exert clinical efficacy against various types of cancer through reinvigoration of exhausted CD8+ T cells that attack cancer cells directly in the tumor microenvironment (TME). Using single-cell sequencing and mou
Externí odkaz:
https://doaj.org/article/a16afc6c6d2a44839375efb4ad0cb6e6
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 5, Pp 356-373 (2021)
Abstract We previously found that N‐89 and its derivative, N‐251, which are being developed as antimalarial compounds, showed multiple antiviral activities including hepatitis C virus (HCV). In this study, we focused on the most characterized ant
Externí odkaz:
https://doaj.org/article/fc814201086c4834a23695951c5967a9
Autor:
Youki Ueda, Weilin Gu, Hiromichi Dansako, Hye-Sook Kim, Sayaka Yoshizaki, Nobuaki Okumura, Tomohiro Ishikawa, Hironori Nishitsuji, Fumihiro Kato, Takayuki Hishiki, Shinya Satoh, Koji Ishii, Michiaki Masuda, Kunitada Shimotohno, Masanori Ikeda, Nobuyuki Kato
Publikováno v:
Biochemistry and Biophysics Reports, Vol 15, Iss , Pp 1-6 (2018)
The chemically synthesized endoperoxide compound N-89 and its derivative N-251 were shown to have potent antimalarial activity. We previously demonstrated that N-89 and N-251 potently inhibited the RNA replication of hepatitis C virus (HCV), which be
Externí odkaz:
https://doaj.org/article/1aaa01e39e214450a7e4c97a3e2a8aa4
Autor:
Shinya Satoh, Kyoko Mori, Youki Ueda, Hiroe Sejima, Hiromichi Dansako, Masanori Ikeda, Nobuyuki Kato
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118313 (2015)
Ribavirin (RBV) is a potential partner of interferon-based therapy and recently approved therapy using direct acting antivirals for patients with chronic hepatitis C. However, the precise mechanisms underlying RBV action against hepatitis C virus (HC
Externí odkaz:
https://doaj.org/article/b3c8ecec19044e98be8eb23ebbb57949
Publikováno v:
Bio-Protocol, Vol 4, Iss 5 (2014)
Co-immunoprecipitation assay of TLR3-Flag or Myc-MSR1 with HCV RNA is used to identify direct interaction of viral RNA with host proteins that recognize viral RNA to initiate interferon (IFN) signaling, a crucial antiviral response of the host cells.
Externí odkaz:
https://doaj.org/article/aa36af837eec423bb343931f7b9467ae
Autor:
Nobuyuki Kato, Hiroe Sejima, Youki Ueda, Kyoko Mori, Shinya Satoh, Hiromichi Dansako, Masanori Ikeda
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91156 (2014)
The most distinguishing genetic feature of hepatitis C virus (HCV) is its remarkable diversity and variation. To understand this feature, we previously performed genetic analysis of HCV in the long-term culture of human hepatoma HuH-7-derived HCV RNA
Externí odkaz:
https://doaj.org/article/cec58dc712c94ccf95f06fa125fadaef
Autor:
Hiromichi Dansako, Daisuke Yamane, Christoph Welsch, David R McGivern, Fengyu Hu, Nobuyuki Kato, Stanley M Lemon
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003345 (2013)
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health. Understanding how the virus is capable of achieving persistence in the ma
Externí odkaz:
https://doaj.org/article/d2ab2daf2ac74901aa2fab9aed3dd504
Autor:
Youki Ueda, Midori Takeda, Kyoko Mori, Hiromichi Dansako, Takaji Wakita, Hye-Sook Kim, Akira Sato, Yusuke Wataya, Masanori Ikeda, Nobuyuki Kato
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72519 (2013)
BACKGROUND: Persistent hepatitis C virus (HCV) infection causes chronic liver diseases and is a global health problem. Although new triple therapy (pegylated-interferon, ribavirin, and telaprevir/boceprevir) has recently been started and is expected
Externí odkaz:
https://doaj.org/article/44c3076c16694327aded1920622dcfca
Autor:
Youki Ueda, Midori Takeda, Kyoko Mori, Hiromichi Dansako, Takaji Wakita, Hye-Sook Kim, Akira Sato, Yusuke Wataya, Masanori Ikeda, Nobuyuki Kato
Publikováno v:
PLoS ONE, Vol 8, Iss 9 (2013)
[This corrects the article on p. e72519 in vol. 8.].
Externí odkaz:
https://doaj.org/article/fd07c6f8451a47b38bd1ad6fcc1f2889
Autor:
Yasuo Ariumi, Misao Kuroki, Masatoshi Maki, Masanori Ikeda, Hiromichi Dansako, Takaji Wakita, Nobuyuki Kato
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14517 (2011)
BACKGROUND: Recently, lipid droplets have been found to be involved in an important cytoplasmic organelle for hepatitis C virus (HCV) production. However, the mechanisms of HCV assembly, budding, and release remain poorly understood. Retroviruses and
Externí odkaz:
https://doaj.org/article/bbe5233e69dc4f19b5da5f385a31786e