Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Hiromi Yokota"'
Autor:
Osamu Kikuchi, Yuichi Ikeuchi, Masaki Kobayashi, Yoko Tabei, Hiromi Yokota‐Hashimoto, Tadahiro Kitamura
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 9, Pp 1177-1190 (2024)
Abstract Aims/Introduction Imeglimin is a recently approved oral antidiabetic agent that improves insulin resistance, and promotes insulin secretion from pancreatic β‐cells. Here, we investigated the effects of imeglimin on glucagon secretion from
Externí odkaz:
https://doaj.org/article/b421d60f1b0b47b1858c0736d304e692
Autor:
Sho Matsui, Tsutomu Sasaki, Daisuke Kohno, Keisuke Yaku, Ayumu Inutsuka, Hiromi Yokota-Hashimoto, Osamu Kikuchi, Takayoshi Suga, Masaki Kobayashi, Akihiro Yamanaka, Akihiro Harada, Takashi Nakagawa, Tatsushi Onaka, Tadahiro Kitamura
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
SIRT1 is a NAD+-dependent deacetylase whose functions have been linked to organismal longevity, aging and metabolism. Here, Matsui and colleagues show that neuronal SIRT1 can affect nutrient-related dietary choice in mice, and this effect is mediated
Externí odkaz:
https://doaj.org/article/0e6908642176438fbd24e41a6c8e07f1
Autor:
Tsutomu Sasaki, Rika Numano, Hiromi Yokota-Hashimoto, Sho Matsui, Naobumi Kimura, Hideyuki Takeuchi, Tadahiro Kitamura
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-15 (2018)
Abstract A high-fat diet (HFD) causes obesity by promoting excessive energy intake, and simultaneously, by disturbing the timing of energy intake. Restoring the feeding pattern is sufficient to prevent HFD-induced obesity in mice. However, the molecu
Externí odkaz:
https://doaj.org/article/a3a5ddb4a6504a2bba4e5ff8e830ca8a
Autor:
Yukari Ido-Kitamura, Tsutomu Sasaki, Masaki Kobayashi, Hye-Jin Kim, Yong-Soo Lee, Osamu Kikuchi, Hiromi Yokota-Hashimoto, Katsumi Iizuka, Domenico Accili, Tadahiro Kitamura
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47231 (2012)
In liver, glucose utilization and lipid synthesis are inextricably intertwined. When glucose availability exceeds its utilization, lipogenesis increases, leading to increased intrahepatic lipid content and lipoprotein secretion. Although the fate of
Externí odkaz:
https://doaj.org/article/e6af08486ff941eabc7f045643470d28
Autor:
Osamu Kikuchi, Masaki Kobayashi, Kosuke Amano, Tsutomu Sasaki, Tomoya Kitazumi, Hye-Jin Kim, Yong-Soo Lee, Hiromi Yokota-Hashimoto, Yukari-Ido Kitamura, Tadahiro Kitamura
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32249 (2012)
Genetic studies revealed that the ablation of insulin/IGF-1 signaling in the pancreas causes diabetes. FoxO1 is a downstream transcription factor of insulin/IGF-1 signaling. We previously reported that FoxO1 haploinsufficiency restored β cell mass a
Externí odkaz:
https://doaj.org/article/0ae6d14bb0e941d0a2b02ec72e259467
Autor:
Ai Yoshino, Eiji Kobayashi, Takahiro Tsuboyama, Hideyuki Fukui, Noriyuki Tomiyama, Kazuaki Sato, Eiichi Morii, Eiji Nakatani, Naoko Komura, Ikuko Sawada, Yusuke Tanaka, Kensuke Hori, Akihiko Yoshimura, Ryoko Takahashi, Tadashi Iwamiya, Tsuyoshi Hisa, Sadako Nishimura, Toshihiro Kitai, Hiromi Yokota, Mariko Shindo, Hiromi Miyata, Namiko Hashimoto, Kanako Sakiyama, Hazuki Abe, Yutaka Ueda, Tadashi Kimura
Publikováno v:
Annals of Surgical Oncology. 30:2964-2973
Purpose To investigate the clinical practices of diagnosing multicystic cervical lesions as a means to develop a more appropriate diagnostic algorithm for gastric-type adenocarcinoma (GAS) and its precursors. Methods Clinical information for 159 surg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fbe2e4668ff7a7cf58749acdf1b4463
https://doi.org/10.1245/s10434-022-13033-7
https://doi.org/10.1245/s10434-022-13033-7
Autor:
Hiromi YOKOTA, katsushige FUJIMOTO, Tomohiko KAWAKAMI, Sakiko NAGAYAMA, Kodai OKAZAKI, Etsuyo MAKUUCHI, Yuta ABE, Masahiko OTAKA
Publikováno v:
Journal of Japan Society for Fuzzy Theory and Intelligent Informatics. 35:561-566
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab2ad4369967fe0b999048aba821eaba
https://doi.org/10.3156/jsoft.35.1_561
https://doi.org/10.3156/jsoft.35.1_561
Autor:
Ai Yoshino, Eiji Kobayashi, Takahiro Tsuboyama, Hideyuki Fukui, Noriyuki Tomiyama, Kazuaki Sato, Eiichi Morii, Eiji Nakatani, Naoko Komura, Ikuko Sawada, Yusuke Tanaka, Kensuke Hori, Akihiko Yoshimura, Ryoko Takahashi, Tadashi Iwamiya, Tsuyoshi Hisa, Sadako Nishimura, Toshihiro Kitai, Hiromi Yokota, Mariko Shindo, Hiromi Miyata, Namiko Hashimoto, Kanako Sakiyama, Hazuki Abe, Yutaka Ueda, Tadashi Kimura
Publikováno v:
Annals of Surgical Oncology. 30:2974-2975
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b42b3c34a73db4fbf4954bf7bccac41
https://doi.org/10.1245/s10434-022-13084-w
https://doi.org/10.1245/s10434-022-13084-w
Autor:
Norikiyo Honzawa, Kei Fujimoto, Masaki Kobayashi, Daisuke Kohno, Osamu Kikuchi, Hiromi Yokota-Hashimoto, Eri Wada, Yuichi Ikeuchi, Yoko Tabei, Gerald W. Dorn, Kazunori Utsunomiya, Rimei Nishimura, Tadahiro Kitamura
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 4003
The pathophysiology of type 2 diabetes involves insulin and glucagon. Protein kinase C (Pkc)-δ, a serine–threonine kinase, is ubiquitously expressed and involved in regulating cell death and proliferation. However, the role of Pkcδ in regulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c373fa2dd95227fbd564815b958d7d89
https://doi.org/10.3390/ijms23074003
https://doi.org/10.3390/ijms23074003
Autor:
Akihiro Yamanaka, Hiromi Yokota-Hashimoto, Ayumu Inutsuka, Akihiro Harada, Takayoshi Suga, Daisuke Kohno, Tadahiro Kitamura, Masaki Kobayashi, Takashi Nakagawa, Sho Matsui, Tsutomu Sasaki, Tatsushi Onaka, Keisuke Yaku, Osamu Kikuchi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
Diet affects health through ingested calories and macronutrients, and macronutrient balance affects health span. The mechanisms regulating macronutrient-based diet choices are poorly understood. Previous studies had shown that NAD-dependent deacetyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ef9a5629d5d897eafc819c84f3196b
http://link.springer.com/article/10.1038/s41467-018-07033-z
http://link.springer.com/article/10.1038/s41467-018-07033-z