Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Hiromi Tamada"'
Publikováno v:
eLife, Vol 9 (2020)
Previously, we showed that cryo fixation of adult mouse brain tissue gave a truer representation of brain ultrastructure in comparison with a standard chemical fixation method (Korogod et al., 2015). Extracellular space matched physiological measurem
Externí odkaz:
https://doaj.org/article/e9f3fca0fbac45f19d65ad13d0f0b75a
Mitochondria‐associated membrane collapse is a common pathomechanism in SIGMAR1‐ and SOD1‐linked ALS
Autor:
Seiji Watanabe, Hristelina Ilieva, Hiromi Tamada, Hanae Nomura, Okiru Komine, Fumito Endo, Shijie Jin, Pedro Mancias, Hiroshi Kiyama, Koji Yamanaka
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 12, Pp 1421-1437 (2016)
Abstract A homozygous mutation in the gene for sigma 1 receptor (Sig1R) is a cause of inherited juvenile amyotrophic lateral sclerosis (ALS16). Sig1R localizes to the mitochondria‐associated membrane (MAM), which is an interface of mitochondria and
Externí odkaz:
https://doaj.org/article/5a0e8df1db3c421faba5a9e7e0a8319f
Autor:
Hiromi Tamada
Publikováno v:
Anatomical Science International.
Morphological analysis of organelles is one of the important clues for understanding the cellular conditions and mechanisms occurring in cells. In particular, nanoscale information within crowded intracellular organelles of tissues provide more direc
Publikováno v:
The Journal of comparative neurologyREFERENCES. 529(16)
The axon initial segment (AIS) is structurally and functionally distinct from other regions of the axon, yet alterations in the milieu of the AIS after brain injury have not been well characterized. In this study, we have examined extracellular and i
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Previously we showed that cryo fixation of brain tissue gave a truer representation of brain ultrastructure in comparison with a standard chemical fixation method (Korogod et al 2005). Extracellular space matched physiological measurements, there wer
Autor:
Akira Nishiyama, Hiromi Tamada, Hiroyuki Konishi, Okiru Komine, Nobuyuki Udagawa, Tomohiko Tamura, Keiko Ozato, Takayuki Okamoto, Steffen Jung, Yosky Kataoka, Masaaki Kobayashi, Katsuaki Sato, Toshiyuki Takai, Hiroshi Kiyama, Tomoo Ogi, Makoto Tsuda, Fumika Osako, Mitsuyo Maeda, Koji Yamanaka, Yuichiro Hara
Publikováno v:
The EMBO Journal
Microglia are the principal phagocytes that clear cell debris in the central nervous system (CNS). This raises the question, which cells remove cell debris when microglial phagocytic activity is impaired. We addressed this question using Siglech dtr
Publikováno v:
Cell and tissue research. 384(1)
The dura mater contains abundant macrophages whose functions remain largely elusive. Recent studies have demonstrated the origin, as well as the gene expression pattern, of dural macrophages (dMΦs). However, their histological features have not been
Autor:
Katsuyoshi Mihara, Sumiko Kiryu-Seo, Naotada Ishihara, Masatoshi Nomura, Hiromi Tamada, Keisuke Ohta, Hiroki Hosokawa, Kei-ichiro Nakamura, Hiroshi Kiyama
Publikováno v:
Journal of Comparative Neurology. 525:2535-2548
Mitochondria undergo morphological changes through fusion and fission for their quality control, which are vital for neuronal function. In this study, we examined three-dimensional morphologies of mitochondria in motor neurons under normal, nerve inj