Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hiromi Takanaga"'
Autor:
Hiromi Takanaga, Toru Kondo, Nobuko Tsuchida-Straeten, Kenji Nishide, Hiroyuki Aburatani, Akira Watanabe
Publikováno v:
Stem Cells. 27:165-174
Multipotential neural stem cells (NSCs) in the central nervous system (CNS) proliferate indefinitely and give rise to neurons, astrocytes, and oligodendrocytes. As NSCs hold promise for CNS regeneration, it is important to understand how their prolif
Publikováno v:
Journal of Neurochemistry. 90:750-757
Regulation of astrocyte differentiation is a key process in the development of the central nervous system (CNS), and disturbance of the differentiation can lead to brain system dysfunction. Here we show that beta-naphthoflavone (betaNF), an agonist o
Autor:
Hideo Utsumi, Hiromi Takanaga, Shuntaro Hara, Osami Nakasugi, Sachiko Matsushita, Motoharu Sakaue, Risa Yoshimi, Manabu Kunimoto
Publikováno v:
Journal of Health Science. 49:311-315
A new testing method for the assessment of hazardous environmental chemicals using cultured human neuronal cells has been developed. This method is based on the image analysis of the neurite extension in human neuroblastoma NB-1 cells: the length of
Publikováno v:
Journal of Neuroscience Research. 69:61-71
The influence of cell density and thyroid hormone (TH) on the development of astrocytes and oligodendrocytes was investigated in primary cultures prepared from rat cerebral hemisphere on embryonic day (E)18. At the beginning of the culture, most of t
Publikováno v:
Experimental Cell Research. 241:363-372
PKN is a fatty acid-activated serine/threonine protein kinase, having a catalytic domain homologous to protein kinase C family. PKN has been recently reported to interact with a small GTP-binding protein Rho and cytoskeletal proteins such as neurofil
Autor:
Hideki Shibata, Yoshitaka Ono, Hiromi Takanaga, Hideyuki Mukai, Masanao Toshimori, Masaki Shimakawa, Masako Miyahara, Michinori Kitagawa
Publikováno v:
Journal of Biological Chemistry. 272:4740-4746
PKN is a fatty acid- and Rho-activated serine/threonine protein kinase, having a catalytic domain homologous to protein kinase C family. To identify components of the PKN-signaling pathway such as substrates and regulatory proteins of PKN, the yeast
Autor:
Hiromi Takanaga, Masaki Shimakawa, Hideki Shibata, Masanao Toshimori, Hiroko Sunakawa, Yoshitaka Ono, Hideyuki Mukai, Masako Miyahara, Michinori Kitagawa
Publikováno v:
Proceedings of the National Academy of Sciences. 93:10195-10199
Effects of environmental stresses on the subcellular localization of PKN were investigated in NIH 3T3, BALB/c 3T3, and Rat-1 cells. The immunofluorescence of PKN resided prominently in the cytoplasmic region in nonstressed cells. When these cells wer
Autor:
Yoshitaka Ono, Hideki Shibata, Masako Miyahara, Hideyuki Mukai, Hiromi Takanaga, Michinori Kitagawa, Masaki Shimakawa
Publikováno v:
Gene. 166:155-159
We have identified a novel putative protein kinase-encoding gene from Schizosaccharomyces pombe (Sp), designated pskl + , by using a highly conserved amino acid (aa) sequence motif to design amplification of DNA fragments using PCR. The putative tran
Autor:
Masaki Shimakawa, Hideki Shibata, Michinori Kitagawa, Yoshitaka Ono, Hideyuki Mukai, K. Mori, Masako Miyahara, K. Hirao, Hiromi Takanaga
Publikováno v:
Biochemical and Biophysical Research Communications. 204:348-356
PKN, a novel protein kinase with catalytic domain homologous to PKC family and unique amino terminal leucine zipper-like sequences, was purified partially from COS7 cells transfected with the cDNA construct encoding human PKN for enzymatic characteri
Autor:
Hiromi Takanaga, Jun Ichi Kuratsu, Takuichiro Hide, Toru Kondo, Tatsuya Takezaki, Hideo Nakamura
Publikováno v:
Cancer science. 102(7)
Recent findings have demonstrated that malignant tumors, including glioblastoma multiforme, contain cancer-initiating cells (also known as cancer stem cells), which self-renew and are malignant, with features of tissue-specific stem cells. As these c