Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hiromi Nakao-Inoue"'
Autor:
Rafael T. Han, Ilia D. Vainchtein, Johannes C.M. Schlachetzki, Frances S. Cho, Leah C. Dorman, Eunji Ahn, Dong Kyu Kim, Jerika J. Barron, Hiromi Nakao-Inoue, Ari B. Molofsky, Christopher K. Glass, Jeanne T. Paz, Anna V. Molofsky
Publikováno v:
The Journal of experimental medicine, vol 220, iss 2
Microglia are critical regulators of brain development that engulf synaptic proteins during postnatal synapse remodeling. However, the mechanisms through which microglia sense the brain environment are not well defined. Here, we characterized the reg
Autor:
Leah C, Dorman, Phi T, Nguyen, Caroline C, Escoubas, Ilia D, Vainchtein, Yinghong, Xiao, Peter V, Lidsky, Haruna, Nakajo, Nicholas J, Silva, Christian, Lagares-Linares, Ellen Y, Wang, Sunrae E, Taloma, Beatriz, Cuevas, Hiromi, Nakao-Inoue, Brianna M, Rivera, Bjoern, Schwer, Carlo, Condello, Raul, Andino, Tomasz J, Nowakowski, Anna V, Molofsky
Publikováno v:
bioRxiv : the preprint server for biology.
Microglia, the innate immune cells of the brain, are exquisitely sensitive to dynamic changes in the neural environment. Using single cell RNA sequencing of the postnatal somatosensory cortex during topographic remapping, we identified a type I inter
Autor:
Rafael T. Han, Jerika T. Barron, Leah C. Dorman, Hiromi Nakao-Inoue, Ilia D. Vainchtein, Anna V. Molofsky, Ari B. Molofsky, Jeanne T. Paz, Eunji Ahn, Johannes C. M. Schlachetzki, Akshaj Joshi, Christopher K. Glass, Frances S. Cho, Tessa Johung
SummaryMicroglia are key remodelers of neuronal synapses during brain development, but the mechanisms that regulate this process and its ultimate impact on neural circuit function are not well defined. We previously identified the IL-1 family cytokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04fe8a65915ae9e6a0996b30fefba0a9
https://doi.org/10.1101/2021.08.05.455250
https://doi.org/10.1101/2021.08.05.455250
Autor:
Caroline C. Escoubas, Leah C. Dorman, Phi T. Nguyen, Christian Lagares-Linares, Haruna Nakajo, Sarah R. Anderson, Beatriz Cuevas, Ilia D. Vainchtein, Nicholas J. Silva, Yinghong Xiao, Peter V. Lidsky, Ellen Y. Wang, Sunrae E. Taloma, Hiromi Nakao-Inoue, Bjoern Schwer, Raul Andino, Tomasz J. Nowakowski, Anna V. Molofsky
SummaryMicroglia are brain resident phagocytes that can engulf synaptic components and extracellular matrix as well as whole neurons. However, whether there are unique molecular mechanisms that regulate these distinct phagocytic states is unknown. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d4dfab35cc3d1bbd40ad782fcefd82
https://doi.org/10.1101/2021.04.29.441889
https://doi.org/10.1101/2021.04.29.441889
Autor:
Mazen A. Kheirbek, Jerika J. Barron, Leah C. Dorman, Phi T. Nguyen, Ilia D. Vainchtein, Rafael T. Han, Hiromi Nakao-Inoue, Ari B. Molofsky, Simon Pan, Anna V. Molofsky, Sunrae E. Taloma
Publikováno v:
Cell
Cell, vol 182, iss 2
Cell, vol 182, iss 2
Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we define a molecular interaction between neurons and microglia that drives experience-dependent synapse remodeling in the hippocampus. We find that the cytokine inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7e9287e241721fc0543de43e166c1c
https://europepmc.org/articles/PMC7497728/
https://europepmc.org/articles/PMC7497728/
Autor:
John G. Miller, Elliott C. Chien, Omar Akil, Leah C. Dorman, Shane A. Liddelow, Anna V. Molofsky, Phi T. Nguyen, Ilia D. Vainchtein, Kevin W. Kelley, Ben A. Barres, Satoru Joshita, Jeanne T. Paz, Frances S. Cho, Gregory Chin, Hiromi Nakao-Inoue, Ari B. Molofsky
Publikováno v:
Science (New York, N.Y.). 359(6381)
Call to action The developing brain initially makes more synapses than it needs. With further development, excess synapses are pruned away, leaving mature circuits. Synapses can be eliminated by microglia, which engulf and destroy them. Vainchtein et
Publikováno v:
Mental Health Weekly Digest; 3/22/2024, p1014-1014, 1p
Publikováno v:
Mental Health Weekly Digest; 11/6/2023, p649-649, 1p