Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hiromi Nagasaki"'
Autor:
Hiromi Nagasaki, Kaoru Mogushi, Yoshimitsu Akiyama, Mari Ishigami-Yuasa, Shinji Tanaka, Hiroshi Fukamachi, Shu Shimada, Hiroyuki Kagechika, Yasuhito Yuasa
Publikováno v:
British Journal of Cancer
Background Diffuse-type gastric cancer (DGC) exhibits rapid disease progression and poor patient prognosis. We have previously established an E-cadherin/p53 double conditional knockout (DCKO) mouse line as the first genetically engineered one, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa86f8b7854e3b509afb2a7332f2fde1
https://pubmed.ncbi.nlm.nih.gov/29527007
https://pubmed.ncbi.nlm.nih.gov/29527007
Autor:
Hiromi Nagasaki, Yasuhito Yuasa, Isao Oze, Miki Watanabe, Yoshimitsu Akiyama, Shu Shimada, Keitaro Matsuo, Yasushi Yatabe
Publikováno v:
Journal of cancer research and clinical oncology. 143(3)
Diffuse-type gastric cancer (DGC) carries a poor prognosis. Effective screening is one measure that might improve the prognosis of this disease. An E-cadherin/p53 double-conditional knockout (DCKO) mouse line recapitulates human DGC morphologically a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b555578e3ff6cd88dbefdee4154ca1
https://pubmed.ncbi.nlm.nih.gov/27909811
https://pubmed.ncbi.nlm.nih.gov/27909811
Autor:
Kai-Feng Pan, Seiji Ito, Wei-Cheng You, Yasuhito Yuasa, Satoyo Hosono, Kouhei Shitara, Hideo Tanaka, Hidemi Ito, Daehee Kang, Keitaro Matsuo, Isao Oze, Yoshimitsu Akiyama, Miki Watanabe, Shunsuke Yoshida, Hiromi Nagasaki
Publikováno v:
International Journal of Cancer. 131:2596-2603
To determine whether or not the methylation status of blood leukocyte DNA can be used as a surrogate marker of the risk for cancer, we quantitatively determined the methylation levels of insulin-like growth factor 2 (IGF2) and TUSC3 in 299 gastric ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c126ab0f0fc5fc89b0e5f9d7948ee83
https://doi.org/10.1002/ijc.27554
https://doi.org/10.1002/ijc.27554
Autor:
Yutaka Hashimoto, Yasuhito Yuasa, Hiromi Nagasaki, Yoshimitsu Akiyama, Kei Nakachi, Kazuyuki Kojima, Tatsuyuki Kawano, Touichirou Takizawa, Kenichi Sugihara, Kazue Imai
Publikováno v:
International Journal of Cancer. 124:2677-2682
Epigenetic silencing of genes by aberrant DNA methylation is recognized as a crucial component of the mechanism underlying tumorigenesis. However, the relationship between DNA methylation and the past lifestyle in cancer patients remains largely unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbff8a0a6edd7d9d94e1245fb47f91af
https://doi.org/10.1002/ijc.24231
https://doi.org/10.1002/ijc.24231
Autor:
Yasuo Ohkura, Hiromi Nagasaki, Touichirou Takizawa, Kei Nakachi, Takehisa Iwai, Morio Koike, Tomoko Nakajima, Masao Tani, Kenichi Sugihara, Yoshimitsu Akiyama, Kazue Imai, Hidekazu Sakai, Yasuhito Yuasa
Publikováno v:
Carcinogenesis. 26:193-200
Epigenetic gene silencing through DNA methylation is one of the important steps in the mechanism underlying tumorigenesis, including in the stomach. Past lifestyle factors of cancer patients, such as intake of vegetables, are very important in affect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212a17e29cb4741f66c55d470dad85b9
https://doi.org/10.1093/carcin/bgh304
https://doi.org/10.1093/carcin/bgh304
Publikováno v:
Journal of Agricultural and Food Chemistry. 51:7066-7072
Absorption, distribution, excretion, and metabolism of clothianidin [(E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine] were investigated after a single oral administration of [nitroimino-(14)C]- or [thiazolyl-2-(14)C]clothianidin to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3012a027d9cbe493325b4007409f5bd5
https://doi.org/10.1021/jf034760f
https://doi.org/10.1021/jf034760f
Publikováno v:
Rinsho Biseibutsu Jinsoku Shindan Kenkyukai shi = JARMAM : Journal of the Association for Rapid Method and Automation in Microbiology. 25(1)
Group B Streptococcus (GBS) are normal flora of the vagina and intestinal, but if the pregnant woman was infected with GBS in the vagina, miscarriage or premature would occur or the newborn would be developed to severe GBS infection. It is recommende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::734def87818c6f00b98d9f2c91739c51
https://pubmed.ncbi.nlm.nih.gov/25537178
https://pubmed.ncbi.nlm.nih.gov/25537178
Publikováno v:
Cancer Letters. 157:185-191
To clarify the roles of the adenomatous polyposis coli (APC) and beta-catenin genes in hereditary nonpolyposis colorectal cancer (HNPCC) tumorigenesis, we searched for their mutations in 14 HNPCC adenomas with microsatellite instability (MSI). Seven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfb3a6f522958bea97d42cc61bfa3d1
https://doi.org/10.1016/s0304-3835(00)00486-9
https://doi.org/10.1016/s0304-3835(00)00486-9
Autor:
Atsushi Muto, Shi-Long Lu, Michio Nagashima, Shozo Baba, Yasuhito Yuasa, Yun-Qing Bai, Hideaki Itoh, Masatoshi Kitamura, Takashi Morisaki, Takeo Iwama, Takehisa Iwai, Yoshimitsu Akiyama, Takehiro Arai, Tadashi Nomizu, Hiromi Nagasaki
Publikováno v:
International Journal of Cancer. 82:512-515
By means of PCR-SSCP and direct sequencing, we detected 12 germ-line mutations of hMSH2 or hMLH1 in 37 Japanese hereditary non-polyposis colorectal cancer (HNPCC) kindreds, of whom 15 satisfied the Amsterdam and 22 the Japanese criteria. The germ-lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09450e868df1345f3a77a8ecd0ef2fe7
https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<512::aid-ijc7>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<512::aid-ijc7>3.0.co
Autor:
Hiromi Nagasaki, Tomoko Ishikawa, Kiyoshi Saitoh, Osmar Kenji Yagi, Yasuhito Yuasa, Yoshimitsu Akiyama
Publikováno v:
Cancer Letters. 125:89-96
Cancer in adenomas are thought to be an excellent model of colorectal carcinogenesis based on the adenoma-carcinoma sequence. We searched for alterations in the APC mutation cluster region, the whole coding regions of TGF-beta type II receptor (RII)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fff0426844caa674ee7507d6d31dad5
https://doi.org/10.1016/s0304-3835(97)00490-4
https://doi.org/10.1016/s0304-3835(97)00490-4