Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hiromi Maune"'
Publikováno v:
Drug Metabolism and Pharmacokinetics. 22:358-366
We investigated the pharmacokinetics (PK) of aripiprazole, a newly developed antipsychotic, and its active metabolite in healthy Japanese, and the influence of CYP2D6 polymorphism on the PK of aripiprazole. Following a single oral 6 mg dose, the mean
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735a4dda7f27ab2b6438eb5d0674a200
https://doi.org/10.2133/dmpk.22.358
https://doi.org/10.2133/dmpk.22.358
Autor:
Atsuhiro Inaba, Hiroshi Takeda, Junichi Azuma, Hiromi Maune, Toshiko Koue, Tsuyoshi Fukuda, Masanori Kubo
Publikováno v:
Drug Metabolism and Pharmacokinetics. 20:55-64
The results of in vitro studies indicated that ARIPIPRAZOLE, a newly developed antipsychotic, is mainly metabolized by the human cytochrome P450 isozymes CYP3A4 and CYP2D6. The objective of the present study was to investigate the influence of itraco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f667f2653d1c4e0bac3eaf2d02966adc
https://doi.org/10.2133/dmpk.20.55
https://doi.org/10.2133/dmpk.20.55
Autor:
Hiromi Maune, Junichi Azuma, Masakazu Naohara, Tsuyoshi Fukuda, Kazuhiro Fukuda, Yuko Nishida, Yuka Ikenaga
Publikováno v:
Drug Metabolism and Pharmacokinetics. 20:113-116
The -1584C/G single nucleotide polymorphism (SNP) in the promoter region of CYP2D6 was suggested to have the potential to influence CYP2D6 activity. In this report, we demonstrated the frequencies of -1584C to G substitution-related alleles, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d25932b550dce65adc4c06f5aa03cd
https://doi.org/10.2133/dmpk.20.113
https://doi.org/10.2133/dmpk.20.113
Autor:
Junichi Azuma, Yuka Ikenaga, Shuichi Fukuen, Isamu Yamamoto, Tadanobu Inaba, Hiromi Maune, Tsuyoshi Fukuda
Publikováno v:
Pharmacogenetics. 12:331-334
In this study, we established useful and reliable methods for the direct detection of the variants of CYP3A5 gene by polymerase chain reaction (PCR) and DdeI restriction analysis. The frequency of CYP3A5 related SNPs in 200 healthy Japanese male subj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9000025d16f0e9cedf5de947e11fd2
https://doi.org/10.1097/00008571-200206000-00009
https://doi.org/10.1097/00008571-200206000-00009
Autor:
Junichi Azuma, Masakazu Naohara, Hiromi Maune, Yuka Ikenaga, Kazuhiro Fukuda, Tsuyoshi Fukuda
Publikováno v:
Drug metabolism and pharmacokinetics. 20(5)
We encountered DNA samples which showed a positive product using a long PCR-based method for the detection of CYP2D6*5, indicating deletion of the entire CYP2D6 gene, but the samples did not show a band related to CYP2D6*5 in either XbaI- or EcoRI-RF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca27675dad8c29aae30d92fe38bf28d
https://pubmed.ncbi.nlm.nih.gov/16272752
https://pubmed.ncbi.nlm.nih.gov/16272752
Autor:
Masakazu Naohara, Isamu Yamamoto, Hiromi Maune, Junichi Azuma, Tsuyoshi Fukuda, Masahiro Otani, Chiaki Senda
Publikováno v:
European journal of clinical pharmacology. 59(5-6)
In vitro studies with human liver microsomes have suggested that the oxidative conversion of mexiletine (MX) to its metabolites is catalyzed by CYP2D6 and is significantly impaired in microsomes with the CYP2D6*10/*10 genotype. Therefore, we examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0bc58cff229fa8170a1ac095cec578
https://pubmed.ncbi.nlm.nih.gov/12937870
https://pubmed.ncbi.nlm.nih.gov/12937870