Výsledky vyhledávání - "Hiromi Kushida"

Prenatal developmental toxicity studies of 1,1,1-trichloro-2,2-bis(4-methoxyphenyl)ethane (methoxychlor) in rats and rabbits

Autor: Hiromi Kushida, Hisao Kawakatsu, Hiroaki Aoyama, Ken L. Takahashi, Masayuki Kikuta, Hitoshi Hojo, Shoji Teramoto, N. Shimizu

Publikováno v: Congenital Anomalies. 41:329-337

The studies were conducted in rats and rabbits to elucidate the potential developmental toxicity of methoxychlor in general accordance with the improved Japanese MAFF guidelines (12-Nousan-No. 8147, 2–1–18, 2000). Methoxychlor dissolved in corn o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae34b9463632620954f5a33cf170dc64
https://doi.org/10.1111/j.1741-4520.2001.tb00843.x

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Prenatal developmental toxicity studies of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p, p‘-DDT) in rats and rabbits

Autor: Hiroaki Aoyama, Hitoshi Hojo, Hiromi Kushida, Shoji Teramoto, Masayuki Kikuta, Koichi Ebino, Hisao Kawakatsu, Ken L. Takahashi, N. Shimizu

Publikováno v: Congenital Anomalies. 41:321-328

The studies were conducted in rats and rabbits to elucidate the potential developmental toxicity of p, p'-DDT in general accordance with the improved Japanese MAFF guidelines (12-Nousan-No. 8147,2–1–18, 2000). p, p'-DDT suspended in 1% aqueous so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ce89d865ea083196093903f99ad1880
https://doi.org/10.1111/j.1741-4520.2001.tb00842.x

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Hepatocellular Carcinoma Induction in LEC Rats by a Low Dose of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Autor: Hiroyuki Tsuda, Hiromi Kushida, Minako Nagao, Keiji Wakabayashi, Michio Mori, Katsuhiko Enomoto, Noritoshi Takeichi, Takashi Sugimura, Hideko Sone

Publikováno v: Japanese Journal of Cancer Research : Gann

A food-borne heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), induces hepatocellular carcinomas (HCCs) in F344 male rats at an incidence of 95%, when fed in the diet at 400 ppm for 61 weeks. In this study, the effect of a lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdb4b29c850b137f375ffee4919bf6d
https://doi.org/10.1111/j.1349-7006.1996.tb00195.x

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DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis

Autor: Hiromi Kushida, Masatoshi Watanabe, Minako Nagao, Masako Ochiai, Keiji Wakabayashi, Takashi Sugimura

Publikováno v: Carcinogenesis. 17:95-98

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induces colon tumors in male, but not female, F344 rats. We investigated the mechanisms leading to this difference by measuring the level of PhIP-DNA adducts, the enhancement of cell proliferatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03e00f1a047b2dd6e6eb4f8ab85218f
https://doi.org/10.1093/carcin/17.1.95

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Rare Activation of the Human c‐Ha‐ras Transgene of Mice in Hemangioendothelial Sarcomas and Liver Tumors Induced by Glu‐P‐1

Autor: Rie Inoue, Takashi Sugimura, Makoto Asamoto, Toshikazu Ushijima, Hiromi Kushida, Hidetaka Sato, Keiji Wakabayashi, Minako Nagao, Motoya Katsuki, Makoto Katami

Publikováno v: Japanese Journal of Cancer Research : Gann

A transgenic mouse (Tg), having the human c-Ha-ras proto-oncogene, has been demonstrated to develop hemangioendothelial sarcomas (HESs) which are associated with the transgene mutation, but not to develop liver tumors. In this study, we examined the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b3f66e409f3606db9b308668797968
http://europepmc.org/articles/PMC5921135

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Formation and Removal of DNA Adducts in the Liver of Rats Chronically Fed the Food-borne Carcinogen, 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Autor: Takashi Sugimura, Hidetaka Sato, Hiromi Kushida, Minako Nagao, Misako Hirose, Keiji Wakabayashi, Masako Ochiai

Publikováno v: Japanese Journal of Cancer Research : Gann

Effects of chronic administration of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) at 0.4, 8 and 400 ppm in the diet on DNA adduct formation and removal in the rat liver were examined by the 32 P-postlabeling method. The 0.4 and 8 ppm doses f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185d601d0022c16b8b630ca89d9bc4ec
https://doi.org/10.1111/j.1349-7006.1995.tb02428.x

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Dose-response study of MeIQx carcinogenicity in F344 male rats

Autor: Reiko Kurosaka, Hiromi Kushida, Makoto Katami, Minako Nagao, Keiji Wakabayashi, Hidetaka Sato

Publikováno v: Cancer Letters. 83:31-35

The dose-dependence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity when given in the diet continuously throughout the experiment (56 weeks) at doses of 100, 200 and 400 ppm, was examined in F344 male rats. Tumors developed d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459fd8d37495e2728a895ecbf80e7c61
https://doi.org/10.1016/0304-3835(94)90295-x

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Effects of Chronic Administration of Low Doses of 2-Ammo-3,8-dimethylimidazo-[4,5-f]qumoxaline on Glutathione S-Transferase Placental Form-positive Foci Development in the Livers of Rats Fed a Choline-deficient Diet

Autor: Hiromi Kushida, Masako Ochiai, Keiji Wakabayashi, Minako Nagao, Takashi Sugimura, Hideko Sone

Publikováno v: Japanese Journal of Cancer Research : Gann

Effects of chronic administration of 2‐amino‐3,8‐dimethylimidazo[4,S‐f]quinoxaline (MeIQx) at the very low doses of 0.4 and 4 ppm, respectively 1000‐ and 100‐fold less than the dose shown to be carcinogenic (400 ppm), on the liver of rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2e3a8c989aca711487e3203981998f
https://doi.org/10.1111/j.1349-7006.1993.tb02058.x

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Inhibitory Effect of 2‐0‐Octadecylascorbic Acid in Agglutination Assay with Concanavalin A; Short‐term Examination of Rat Urinary Bladder Carcinogenesis

Autor: Hideko Sone, Mika Suzuki, Takashi Sugimura, Tadao Kakizoe, Keiji Wakabayashi, Minako Nagao, Hiromi Kushida, Kiyoshi Sugiyama

Publikováno v: Japanese Journal of Cancer Research : Gann

A derivative of ascorbic acid, 2-O-octadecylascorbic acid (CV-3611), is a strong scavenger of active oxygen species. We examined the effect of CV-3611 on a short-term test of bladder Carcinogenesis, using Concanavalin A (Con A) -dependent agglutinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5923ee7ab871b36ce0df67d2485225cf
http://europepmc.org/articles/PMC5918435

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Tissue-specific mutational spectra of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in the liver and bone marrow of lacI transgenic mice

Autor: Makoto Hayashi, Masako Ochiai, Hiromi Kushida, Minako Nagao, Takashi Sugimura, Yoko Hosoya, Toshikazu Ushijima, Toshio Sofuni, Takayoshi Suzuki, Keiji Wakabayashi

Publikováno v: Carcinogenesis. 15(12)

2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) is a food-borne heterocyclic amine, so clarification of its mutational spectrum is important for evaluation of its carcinogenic risk to humans. The mutational spectrum of MeIQ was investigated in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003b39566450920c693470975c3c7bac
https://pubmed.ncbi.nlm.nih.gov/8001238

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