Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hiromi Kazuno"'
Autor:
Satoru Ito, Sachie Otsuki, Hirokazu Ohsawa, Atsushi Hirano, Hideki Kazuno, Satoshi Yamashita, Kosuke Egami, Yoshihiro Shibata, Ikuo Yamamiya, Fumiaki Yamashita, Yasuo Kodama, Kaoru Funabashi, Hiromi Kazuno, Toshiharu Komori, Satoshi Suzuki, Hiroshi Sootome, Hiroshi Hirai, Takeshi Sagara
Publikováno v:
ACS Medicinal Chemistry Letters. 14:396-404
Autor:
Ryugo Teranishi, Tsuyoshi Takahashi, Yuuki Obata, Toshirou Nishida, Shuichi Ohkubo, Hiromi Kazuno, Yurina Saito, Satoshi Serada, Minoru Fujimoto, Yukinori Kurokawa, Takuro Saito, Kazuyoshi Yamamoto, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Seiichi Hirota, Tetsuji Naka, Hidetoshi Eguchi, Yuichiro Doki
Publikováno v:
International Journal of Cancer. 152:2580-2593
Autor:
Shuichi Ohkubo, Takashi Mizutani, Naoya Fujita, Masafumi Kumazaki, Toru Takenaka, Satoshi Suzuki, Yu Komiya, Fumio Nakagawa, Hiromi Kazuno, Akihiro Hashimoto, Shingo Tsuji, Hiroaki Ochiiwa, Hiromi Muraoka, Chihoko Yoshimura
Supplementary Figure S2. NAE inhibitory effects of TAS4464. (A) E1 inhibitory effects of TAS4464 on HCT116 cells. Cells were treated with TAS4464 for 1 h. (B) Competition assay with non-labeled TAS4464. HCT116 cells were pre-treated with non-labeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd916f7f9005f9e8299c5ec902406aa
https://doi.org/10.1158/1535-7163.22510492
https://doi.org/10.1158/1535-7163.22510492
Autor:
Shuichi Ohkubo, Takashi Mizutani, Naoya Fujita, Masafumi Kumazaki, Toru Takenaka, Satoshi Suzuki, Yu Komiya, Fumio Nakagawa, Hiromi Kazuno, Akihiro Hashimoto, Shingo Tsuji, Hiroaki Ochiiwa, Hiromi Muraoka, Chihoko Yoshimura
Supplementary Figure S6. in vivo pharmacodynamic effects of TAS4464 in the GRANTA-519 (MCL) xenograft model (A) and SU-CCS-1 (clear cell sarcoma) xenograft model (B). Tumors were harvested at the indicated times after the administration of a single i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a158363be140225d086bf43a9add79e
https://doi.org/10.1158/1535-7163.22510480
https://doi.org/10.1158/1535-7163.22510480
Autor:
Shuichi Ohkubo, Takashi Mizutani, Naoya Fujita, Masafumi Kumazaki, Toru Takenaka, Satoshi Suzuki, Yu Komiya, Fumio Nakagawa, Hiromi Kazuno, Akihiro Hashimoto, Shingo Tsuji, Hiroaki Ochiiwa, Hiromi Muraoka, Chihoko Yoshimura
Supplementary Figure S1. Synthesis procedures and characterization data for the synthesis of TAS4464.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a24dc5a2a352467b51beca163f03ee4
https://doi.org/10.1158/1535-7163.22510495.v1
https://doi.org/10.1158/1535-7163.22510495.v1
Autor:
Shuichi Ohkubo, Takashi Mizutani, Naoya Fujita, Masafumi Kumazaki, Toru Takenaka, Satoshi Suzuki, Yu Komiya, Fumio Nakagawa, Hiromi Kazuno, Akihiro Hashimoto, Shingo Tsuji, Hiroaki Ochiiwa, Hiromi Muraoka, Chihoko Yoshimura
Supplementary Figure S3. TAS4464 is effective against THP-1 cells and HCT116 cells. In vitro pharmacodynamic activity of TAS4464 on HCT116 cells and on THP-1 cells (A). (B,C ) Time dependent cytotoxicity of TAS4464. THP-1 cells and HCT116 cells were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d55089f8fb9485c759edbc807d18aff
https://doi.org/10.1158/1535-7163.22510489.v1
https://doi.org/10.1158/1535-7163.22510489.v1
Autor:
Shuichi Ohkubo, Takashi Mizutani, Naoya Fujita, Masafumi Kumazaki, Toru Takenaka, Satoshi Suzuki, Yu Komiya, Fumio Nakagawa, Hiromi Kazuno, Akihiro Hashimoto, Shingo Tsuji, Hiroaki Ochiiwa, Hiromi Muraoka, Chihoko Yoshimura
Supplementary Figure S4. TAS4464 gene signature. (A) Differentially expressed genes (1373 genes) between sensitive and insensitive cells (t-test, p-value
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3fd0173418711d0ee597d4f5dfa099
https://doi.org/10.1158/1535-7163.22510486.v1
https://doi.org/10.1158/1535-7163.22510486.v1
Autor:
Shuichi Ohkubo, Takashi Mizutani, Naoya Fujita, Masafumi Kumazaki, Toru Takenaka, Satoshi Suzuki, Yu Komiya, Fumio Nakagawa, Hiromi Kazuno, Akihiro Hashimoto, Shingo Tsuji, Hiroaki Ochiiwa, Hiromi Muraoka, Chihoko Yoshimura
Supplementary Figure S5. Body weigh change during the antitumor efficacy test. (A) CCRF-CEM, low dose. (B) CCRF-CEM, high dose. (C) GRANTA-519. (D) SU-CCS-1.(E)LU5266.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a11fa57feca28a0f6b6bd682caf98a4
https://doi.org/10.1158/1535-7163.22510483.v1
https://doi.org/10.1158/1535-7163.22510483.v1
Autor:
Shuichi Ohkubo, Takashi Mizutani, Naoya Fujita, Masafumi Kumazaki, Toru Takenaka, Satoshi Suzuki, Yu Komiya, Fumio Nakagawa, Hiromi Kazuno, Akihiro Hashimoto, Shingo Tsuji, Hiroaki Ochiiwa, Hiromi Muraoka, Chihoko Yoshimura
NEDD8-activating enzyme (NAE) is an essential E1 enzyme of the NEDD8 conjugation (neddylation) pathway, which controls cancer cell growth and survival through activation of cullin-RING ubiquitin ligase complexes (CRL). In this study, we describe the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b25d105f9e3d5d120a60e80b9f9b41
https://doi.org/10.1158/1535-7163.c.6539635.v1
https://doi.org/10.1158/1535-7163.c.6539635.v1
Autor:
Shuichi Ohkubo, Takashi Mizutani, Naoya Fujita, Masafumi Kumazaki, Toru Takenaka, Satoshi Suzuki, Yu Komiya, Fumio Nakagawa, Hiromi Kazuno, Akihiro Hashimoto, Shingo Tsuji, Hiroaki Ochiiwa, Hiromi Muraoka, Chihoko Yoshimura
Supplementary materials including cell line, antibodies information and methods including pharmacokinetics and signature score.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64a9ad597298a1589d52b878b9848ae
https://doi.org/10.1158/1535-7163.22510477.v1
https://doi.org/10.1158/1535-7163.22510477.v1