An in vitro model of polycystic liver disease using genome-edited human inducible pluripotent stem cells

Autor: Akihide Kamiya, Hiromi Chikada, Kinuyo Ida, Emi Ando, Kota Tsuruya, Tatehiro Kagawa, Yutaka Inagaki

Publikováno v: Stem Cell Research, Vol 32, Iss , Pp 17-24 (2018)

In the developing liver, bile duct structure is formed through differentiation of hepatic progenitor cells (HPC) into cholangiocytes. A subtype of polycystic liver diseases characterized by uncontrolled expansion of bile ductal cells is caused by gen

Externí odkaz: https://doaj.org/article/755196ff4c024f70b531721b3bfb7981

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Autor: Ary Marsee, Floris J.M. Roos, Monique M.A. Verstegen, Helmuth Gehart, Eelco de Koning, Frédéric Lemaigre, Stuart J. Forbes, Weng Chuan Peng, Meritxell Huch, Takanori Takebe, Ludovic Vallier, Hans Clevers, Luc J.W. van der Laan, Bart Spee, Floris Roos, Monique Verstegen, Stuart Forbes, Luc van der Laan, Sylvia Boj, Pedro Baptista, Kerstin Schneeberger, Carol Soroka, Markus Heim, Sandro Nuciforo, Kenneth Zaret, Yoshimasa Saito, Matthias Lutolf, Vincenzo Cardinale, Ben Simons, Sven van IJzendoorn, Akihide Kamiya, Hiromi Chikada, Shuyong Wang, Seon Ju Mun, Myung Jin Son, Tamer Tevfik Onder, James Boyer, Toshiro Sato, Nikitas Georgakopoulos, Andre Meneses, Laura Broutier, Luke Boulter, Dominic Grün, Jan IJzermans, Benedetta Artegiani, Ruben van Boxtel, Ewart Kuijk, Guido Carpino, Gary Peltz, Jesus Banales, Nancy Man, Luigi Aloia, Nicholas LaRusso, Gregory George, Casey Rimland, George Yeoh, Anne Grappin-Botton, Daniel Stange, Nicole Prior, Janina E.E. Tirnitz-Parker, Emma Andersson, Chiara Braconi, Nicholas Hannan, Wei-Yu Lu, Stephen Strom, Pau Sancho-Bru, Shinichiro Ogawa, Vincenzo Corbo, Madeline Lancaster, Huili Hu, Sabine Fuchs, Delilah Hendriks

Publikováno v: Cell Stem Cell
Cell Stem Cell, 28(5), 816-832. Cell Press
Cell Stem Cell, Vol. 28, no. 5, p. 816-832 (2021)
Cell Stem Cell, 28(5), 816-832. CELL PRESS
Cell Stem Cell, 28(5), 816. Cell Press

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2ad5dde6f10e8b90de604b88f3f1ff

Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism

Autor: Kinuyo Ida, Akemi Sakamoto, Akihide Kamiya, Hiromi Chikada, Yutaka Inagaki, Emi Ando

Publikováno v: Laboratory Investigation. 98:1500-1511

The adult liver performs many metabolic functions for maintaining homeostasis. There are several sex differences in liver function and disease pathogenesis. One important function of the liver is drug metabolism, where cytochrome p450s (CYPs) in hepa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ffcd7c045cb14ad91c6e8146dda71e
https://doi.org/10.1038/s41374-018-0088-6

Molecular Mechanisms Regulating the Proliferation and Maturation of Hepatic Progenitor Cells During Liver Development

Autor: Akihide Kamiya, Hiromi Chikada

The liver is the central organ regulating homeostatic processes such as detoxification, amino acid and lipid metabolism, and serum protein expression. For these adult liver functions, the liver parenchymal cells or hepatocytes express many metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8dce4293b2d5377d204a753f05c39a77
https://doi.org/10.1016/b978-0-12-812301-0.00002-5

Liver maturation deficiency in p57−/− mice occurs in a hepatocytic p57Kip2 expression-independent manner

Autor: Tomoyuki Yamaguchi, Keiichi I. Nakayama, Ayaka Yanagida, Hiromi Chikada, Megumi Kato-Itoh, Hiromitsu Nakauchi, Ayumi Umino, Keiichi Ito, Hideyuki Sato, Toshihiro Kobayashi, Yuji Yamazaki, Akihide Kamiya

Publikováno v: Developmental Biology. 407:331-343

Fetal hepatic stem/progenitor cells, hepatoblasts, are highly proliferative cells and the source of both hepatocytes and cholangiocytes. In contrast, mature hepatocytes have a low proliferative potency and high metabolic functions. Cell proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5b0b2278fa0deb6c04e5f3daf738b47
https://doi.org/10.1016/j.ydbio.2015.07.004