Výsledky vyhledávání - "Hiromi Tanji"

Akademický článek

Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists

Autor: Yi Yang, Adam Csakai, Shuangshuang Jiang, Christina Smith, Hiromi Tanji, Jian Huang, Torey Jones, Kentaro Sakaniwa, Lindsey Broadwell, Chengrui Shi, Subada Soti, Umeharu Ohto, Yaohui Fang, Shu Shen, Fei Deng, Toshiyuki Shimizu, Hang Yin

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Toll-like receptor 8 (TLR8) plays essential roles in the innate immune response to viral single-stranded RNA (ssRNA), so small molecule modulators of TLR8 are of interest, however adverse effects limit their use. Here, the authors report a tetrasubst

Externí odkaz: https://doaj.org/article/83bd70c8f89a49098e079e0d211e760d

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Akademický článek

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.

Autor: Lakshmi Ganapathi, Simon Van Haren, David J Dowling, Ilana Bergelson, Nikunj M Shukla, Subbalakshmi S Malladi, Rajalakshmi Balakrishna, Hiromi Tanji, Umeharu Ohto, Toshiyuki Shimizu, Sunil A David, Ofer Levy

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134640 (2015)

Newborns and young infants are at higher risk for infections than adults, and manifest suboptimal vaccine responses, motivating a search for novel immunomodulators and/or vaccine adjuvants effective in early life. In contrast to most TLR agonists (TL

Externí odkaz: https://doaj.org/article/696380fd21fe44ccb21fccde2a8a3ea0

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