Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Hiromi, Okabe"'
Autor:
Kanji Yamaguchi, Yuya Seko, Takamitsu Sakai, Satomi Kitano, Hiromi Okabe, Seita Kataoka, Michihisa Moriguchi, Atsushi Umemura, Yoshito Itoh
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Chronic liver disease includes nonalcoholic fatty liver disease, progresses from steatosis and hepatitis to fibrosis and cirrhosis, with hemodynamic changes in portal blood flow. This study aimed to compare portal vein hemodynamics with live
Externí odkaz:
https://doaj.org/article/ef43a2a6316f423f90ffa7c0fc6d30ff
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:3873-3878
A single inhaled dose of laninamivir octanoate (LO), a long-acting neuraminidase inhibitor, exhibits efficacy in treating both adult and pediatric patients with influenza virus infection. The intrapulmonary pharmacokinetics (PK) of LO and laninamivir
Publikováno v:
The Journal of Clinical Pharmacology. 51:243-251
This open-label, single-dose study assessed the safety and pharmacokinetics of laninamivir, a new long-acting neuraminidase inhibitor, after an inhaled 20-mg dose of its prodrug, CS-8958, to a total of 20 subjects with normal, mild, moderate, or seve
Publikováno v:
Biological and Pharmaceutical Bulletin. 27:1422-1427
To investigate the mechanism responsible for the increased bioavailability of propranolol in bilateral ureter-ligated (BUL) rats, the intestinal absorption and hepatic extraction of propranolol and metoprolol were evaluated. The initial absorption ra
Autor:
Masato Taguchi, Masato Yasuhara, Akiko Mizukami, Yukiya Hashimoto, Tetsuya Aiba, Hiromi Okabe
Publikováno v:
Journal of Pharmacy and Pharmacology. 55:479-486
The mechanisms responsible for the increased bioavailability of propranolol in renal dysfunction were investigated in rats. Experimental acute renal failure (ARF) was induced by intraperitoneal injection of cisplatin (5 mg kg−1). ARF induced a sign
Publikováno v:
Pharmaceutical Research. 20:1591-1594
Purpose. The hepatic and intestinal metabolic activities of P450 were evaluated in rats with surgery- and drug-induced renal dysfunction.
Publikováno v:
Journal of Pharmacy and Pharmacology. 54:65-70
The effects of renal failure on the hepatic and intestinal extraction of tacrolimus were evaluated to examine the mechanisms for the increased bioavailability of this drug in cisplatin-induced renal failure model rats. Tacrolimus extractions in the l
Publikováno v:
Gan to kagaku ryoho. Cancerchemotherapy. 40
It is important to know the mental state of the primary caregiver for patients requiring advanced home care. Herein, we report cases of failed medical treatment due to primary caregivers with psychological problems and a strong desire to have the pat
Autor:
Kimura Takako, Hiromi Okabe, Nobuko Matsushima, Tomohiro Honda, Atsushi Yamasaki, Yoko Kaneno-Urasaki, Takashi Ito, Takashi Izumi
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 42(3)
(2R,3R,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-3-yl 4-O-(6-deoxy-β-D-glucopyranosyl)-α-D-glucopyranoside (CS-1036), which is an α-amylase inhibitor, exhibited biphasic and sustained elimination with a long t1/2 (18.4-30.0 hours) in rats and monk
Publikováno v:
Journal of Pharmacy and Pharmacology. 52:1467-1472
The effects of renal failure on the pharmacokinetics and bioavailability of tacrolimus were investigated in rats. Experimental renal dysfunction was induced by intraperitoneal injection of cisplatin (5 mg kg−1) into rats. The blood concentration of