Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Hiromasa Yoshioka"'
Publikováno v:
MethodsX, Vol 6, Iss , Pp 2013-2020 (2019)
Luciferase-based reporter assays are one of the most common cell-based screening formats for drug discovery, and simultaneous evaluation of the cytotoxic effect of test compounds is of great value in reducing false-positives. Here we share a multiple
Externí odkaz:
https://doaj.org/article/b0e1b394f1a04f74944c5c047e09bec4
Autor:
Ryuta Shioi, Fumika Karaki, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Minoru Ishikawa, Kosuke Dodo, Yuichi Hashimoto, Mikiko Sodeoka, Kenji Ohgane
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243746 (2020)
Niemann-Pick disease type C is a rare, fatal neurodegenerative disorder characterized by massive intracellular accumulation of cholesterol. In most cases, loss-of-function mutations in the NPC1 gene that encodes lysosomal cholesterol transporter NPC1
Externí odkaz:
https://doaj.org/article/c03a1b4d91de4d8c94c1950b585a4f7f
Publikováno v:
Anticancer Research. 42:4173-4178
Standard treatment options for primary central nervous system lymphoma (PCNSL) include high-dose methotrexate (HD-MTX)-based drug therapy and whole-brain radiation therapy. However, there are many cases in which these standard treatment options are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b87cd0a07758f66c7a5270575b08f0f
https://doi.org/10.21873/anticanres.15917
https://doi.org/10.21873/anticanres.15917
Autor:
Kiyoshi Tsuji, Jun C. Takahashi, Hiromasa Yoshioka, Hisashi Kubota, Kentaro Furukawa, Naoki Nakano, Nobuhiro Nakagawa, Norihito Fukawa, Kazuhiro Nagatsuka
Publikováno v:
Journal of Neuroendovascular Therapy. 16:127-134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b17b261f0f7a4eaab8fa26f0fc4eaf22
https://doi.org/10.5797/jnet.tn.2020-0115
https://doi.org/10.5797/jnet.tn.2020-0115
Autor:
Kota Kawamura, Hiromasa Yoshioka, Chikako Sato, Tomoko Yajima, Yuuki Furuyama, Kouji Kuramochi, Kenji Ohgane
Publikováno v:
Bioorganicmedicinal chemistry. 78
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway, and competitive inhibitors targeting the catalytic domain of this enzyme, so-called statins, are widely used for the treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d5ec1723e733d3576defa28abfb158
https://pubmed.ncbi.nlm.nih.gov/36580745
https://pubmed.ncbi.nlm.nih.gov/36580745
Autor:
Hiromasa Yoshioka, Tatsuro Kawamura, Makoto Muroi, Yasumitsu Kondoh, Kaori Honda, Makoto Kawatani, Harumi Aono, Herbert Waldmann, Nobumoto Watanabe, Hiroyuki Osada
Publikováno v:
ACS chemical biology. 17(2)
Glutathione peroxidase 4 (GPX4) is an intracellular enzyme that oxidizes glutathione while reducing lipid peroxides and is a promising target for cancer therapy. To date, several GPX4 inhibitors have been reported to exhibit cytotoxicity against canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca476222ad59cd4e44ec3a3f16d0cab
https://pubmed.ncbi.nlm.nih.gov/35128925
https://pubmed.ncbi.nlm.nih.gov/35128925
Publikováno v:
Int Cancer Conf J
We report that tirabrutinib was administered via nasogastric tubes to treat an elderly patient with primary central nervous system lymphoma (PCNSL). The patient was a 76-year-old woman who underwent endoscopic biopsy of multiple intracerebral masses,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6e930813e401b20bd699358b0ec79a
https://europepmc.org/articles/PMC8421486/
https://europepmc.org/articles/PMC8421486/
Publikováno v:
Anticancer research. 41(8)
Background/aim Leptomeningeal carcinomatosis (LMC) with hydrocephalus is particularly difficult to treat, and its prognosis is extremely poor. The therapeutic outcomes of 14 patients with LMC-associated hydrocephalus who were treated with cerebrospin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a5d6698f51ac256ec8985ba3d1de35
https://pubmed.ncbi.nlm.nih.gov/34281889
https://pubmed.ncbi.nlm.nih.gov/34281889
Publikováno v:
Anticancer research. 40(8)
Background/aim Recent advances in systemic chemotherapy, including molecularly targeted therapy, have dramatically improved survival for patients with advanced non-small cell lung cancer. We retrospectively analyzed the clinical outcomes of surgical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67345c659ef8be212f3b8a6546b185f2
https://pubmed.ncbi.nlm.nih.gov/32727808
https://pubmed.ncbi.nlm.nih.gov/32727808
Autor:
Fumika Karaki, Yuichi Hashimoto, Ryuta Shioi, Kosuke Dodo, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Mikiko Sodeoka, Kenji Ohgane, Minoru Ishikawa
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0243746 (2020)
PLoS ONE, Vol 15, Iss 12, p e0243746 (2020)
Niemann-Pick disease type C is a rare, fatal neurodegenerative disorder characterized by massive intracellular accumulation of cholesterol. In most cases, loss-of-function mutations in theNPC1gene that encodes lysosomal cholesterol transporter NPC1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a96f50d2ba2fdb3222fb63f0499f9e
https://pubmed.ncbi.nlm.nih.gov/33315900
https://pubmed.ncbi.nlm.nih.gov/33315900