Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hiromasa Oka"'
Autor:
Toshihiro Watanabe, Koichi Yonezawa, Takahiro Kuramochi, Kazuhiro Ikegai, Seiji Tamura, Norio Asai, Tetsuo Kiso, Akio Kamikawa, Satoshi Miyamoto, Takemoto Yukihiro, Hiromasa Oka, Shohei Shirakami
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:3716-3726
A new series of transient receptor potential vanilloid type 1 (TRPV1) antagonists were designed and synthesized from N-(3-hydroxyphenyl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride (8). SAR studies identified (R)-N-(1-methyl-2-oxo-1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e645480def4cc351f241cf20a0e41756
https://doi.org/10.1016/j.bmc.2018.06.001
https://doi.org/10.1016/j.bmc.2018.06.001
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:257-265
Lysophosphatidic acid (LPA) plays an important role in a variety of cellular functions. In particular, LPA5 receptor is highly expressed in spinal cord and dorsal root ganglion, which are associated with pain. This fact prompted us to hypothesize tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725703d1312a1ee066b0cde819b735fa
https://doi.org/10.1016/j.bmc.2017.11.038
https://doi.org/10.1016/j.bmc.2017.11.038
Autor:
Hiromasa Oka, Hideki Hiyama, Toshihiro Sekizawa, Tetsuo Kiso, Toshiaki Aoki, Nobuhito Murai, Tomonari Watabiki
Publikováno v:
Neuropharmacology. 126:97-107
Lysophosphatidic acid (LPA) is a bioactive lipid that acts via at least six G protein-coupled receptors, LPA receptors 1-6 (LPA1-6), for various physiological functions. We examined (1) whether LPA5 is involved in pain signaling in the spinal cord; a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac05ccad456207c87686357248cafc7
https://doi.org/10.1016/j.neuropharm.2017.08.032
https://doi.org/10.1016/j.neuropharm.2017.08.032
Publikováno v:
Pathogens, Vol 13, Iss 3, p 224 (2024)
Inactivated poliovirus vaccine (IPV), available since 1955, became the first vaccine to be used to protect against poliomyelitis. While the immunogenicity of IPV to prevent paralytic poliomyelitis continues to be irrefutable, its requirement for stro
Externí odkaz:
https://doaj.org/article/5de9c4aeb60041ad9a9295b459e6af65
Autor:
Toshiaki Mitsui, Yohei Nanjo, Noriko Ikarashi, Francisco Muñoz, Javier Pozueta-Romero, Hiromasa Oka, Milagros Rodríguez-López, Kentaro Kaneko, Edurne Baroja-Fernández, Aya Kitajima
Publikováno v:
The Plant Cell. 18:2582-2592
A nucleotide pyrophosphatase/phosphodiesterase (NPP) activity that catalyzes the hydrolytic breakdown of ADP-glucose (ADPG) has been shown to occur in the plastidial compartment of both mono- and dicotyledonous plants. To learn more about this enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a936c319d07f255dd0d9ba85ebd3949
https://doi.org/10.1105/tpc.105.039891
https://doi.org/10.1105/tpc.105.039891
Publikováno v:
Synthesis. :1809-1814
A new family of chiral diazaphospholidines is readily accessible by phosphorylating commercially available (S)-1,1'-binaphthyl-2,2'-diamine. NMR spectroscopy, mass spectrometry and X-ray crystallographic analysis reveal their unique structures. In pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::189b65c69115f06ea6c647908c110c97
https://doi.org/10.1055/s-2003-41036
https://doi.org/10.1055/s-2003-41036
Publikováno v:
Tetrahedron. 55:3605-3614
3- exo -(Dimethylamino)isoborneol efficiently promotes the asymmetric addition of dialkylzincs to aldehydes. In order to characterize the catalytic organozinc species, relative reactivities of various substituted benzaldehydes and organozincs have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1696e586f4ff48b4f0b6db7cf497cc4c
https://doi.org/10.1016/s0040-4020(98)01167-3
https://doi.org/10.1016/s0040-4020(98)01167-3
Publikováno v:
Journal of the American Chemical Society. 120:9800-9809
Asymmetric reaction of dimethylzinc and benzaldehyde in the presence of (2S)-3-exo-(dimethylamino)isoborneol [(2S)-DAIB] exhibits unusual nonlinear phenomena. The enantiomeric purity of the product is much higher than that of the chiral source, DAIB,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbd640dcc3f9977f19a8308ce48b0250
https://doi.org/10.1021/ja981740z
https://doi.org/10.1021/ja981740z
Publikováno v:
Chemistry - A European Journal. 2:1173-1181
Dimethylzinc reacts with (2S)-or (2R)-3-exo-(dimethylamino)isoborneol [(2S)- or (2R)-DAIB] to eliminate methane and produce a tricoordinate methylzinc aminoalkoxide, which forms a dimeric structure. The homochiral dimerization of the enantiomeric com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a18072c1f42c4605d4747acc2a19927
https://doi.org/10.1002/chem.19960020921
https://doi.org/10.1002/chem.19960020921
Publikováno v:
ChemInform. 32
Asymmetric addition of dialkylzincs to aldehydes in the presence of (2S)-3-exo-(dimethylamino)isoborneol [(S)-DAIB] exhibits various nonclassical phenomena. The enantiomeric excess (ee) of the alkylation product, obtained with partially resolved DAIB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3b8f1fbda0441ac5780313b365285cf
https://doi.org/10.1002/chin.200150282
https://doi.org/10.1002/chin.200150282