Výsledky vyhledávání

Akademický článek

Individual variation of the genetic response to bisphenol a in human foreskin fibroblast cells derived from cryptorchidism and hypospadias patients.

Autor: Xian-Yang Qin, Hideko Sone, Yoshiyuki Kojima, Kentaro Mizuno, Katsuhiko Ueoka, Koji Muroya, Mami Miyado, Aya Hisada, Hiroko Zaha, Tomokazu Fukuda, Jun Yoshinaga, Junzo Yonemoto, Kenjiro Kohri, Yutaro Hayashi, Maki Fukami, Tsutomu Ogata

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52756 (2012)

Background/purposeWe hypothesized that polymorphic differences among individuals might cause variations in the effect that environmental endocrine disruptors (EEDs) have on male genital malformations (MGMs). In this study, individual variation in the

Externí odkaz: https://doaj.org/article/67d83a867c9b4833801bf87e09b8a9da

Zobrazit plný text záznamu

Akademický článek

Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients.

Autor: Xian-Yang Qin, Yoshiyuki Kojima, Kentaro Mizuno, Katsuhiko Ueoka, Koji Muroya, Mami Miyado, Hiroko Zaha, Hiromi Akanuma, Qin Zeng, Tomokazu Fukuda, Jun Yoshinaga, Junzo Yonemoto, Kenjiro Kohri, Yutaro Hayashi, Maki Fukami, Tsutomu Ogata, Hideko Sone

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36711 (2012)

The effect of low-dose bisphenol A (BPA) exposure on human reproductive health is still controversial. To better understand the molecular basis of the effect of BPA on human reproductive health, a genome-wide screen was performed using human foreskin

Externí odkaz: https://doaj.org/article/07c19c20bf324e9181240ac97ee3a05d

Zobrazit plný text záznamu

Effects of bisphenol A exposure on the proliferation and senescence of normal human mammary epithelial cells

Autor: Hiroko Zaha, Hiromi Akanuma, Jun Yoshinaga, Linqing Yang, Tomokazu Fukuda, Hideko Sone, Xian-Yang Qin, Qin Zeng

Publikováno v: Cancer Biology & Therapy. 13:296-306

The carcinogenic activity of bisphenol A (BPA) is responsible for stimulating growth in estrogen-dependent breast cancer tissues, cell lines and rodent studies. However, it is not fully understood how this compound promotes mammary carcinogenesis. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c57d4e3e3c9c127e8a5b5c2ce2a3bdd
https://doi.org/10.4161/cbt.18942

Zobrazit plný text záznamu

Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanism

Autor: Xian-Yang Qin, Hideko Sone, Hiroko Zaha, Jun Yoshinaga, Junzo Yonemoto, Reiko Nagano

Publikováno v: Toxicology Letters. 206:152-157

Environmental chemicals with estrogenic activity, known as xenoestrogens, may cause impaired reproductive development and endocrine-related cancers in humans by disrupting endocrine functions. Aryl-hydrocarbon receptor nuclear translocator 2 (ARNT2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c474da16cf5a46ea6f02d804d280e3
https://doi.org/10.1016/j.toxlet.2011.07.007

Zobrazit plný text záznamu

Prenatal exposure to permethrin influences vascular development of fetal brain and adult behavior in mice offspring

Autor: Hidekazu Fujimaki, Reiko Nagano, Hideko Sone, Hiroaki Shiraishi, Toshifumi Yamamoto, Hiroko Zaha, Hiromi Akanuma, Satoshi Imanishi, Masahiro Okura

Publikováno v: Environmental Toxicology. 28:617-629

Pyrethroids are one of the most widely used classes of insecticides and show neurotoxic effects that induce oxidative stress in the neonatal rat brain. However, little is still known about effects of prenatal exposure to permethrin on vascular develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4dff6a3e34717262454620952111dfa
https://doi.org/10.1002/tox.20758

Zobrazit plný text záznamu

Comparative Contribution of the Aryl Hydrocarbon Receptor Gene to Perinatal Stage Development and Dioxin-Induced Toxicity Between the Urogenital Complex and Testis in the Mouse1

Autor: Junzo Yonemoto, Qing Wu, Seiichiroh Ohsako, Hiroko Zaha, Hideko Sone, Takashige Kawakami, Reiko Nagano, Noriho H. Fukuzawa, Chiharu Tohyama, Ryuta Ishimura

Publikováno v: Biology of Reproduction. 82:636-643

TCDD (2,3,7,8-tetrachlorodebenzo-p-dioxin) requires the presence of the aryl hydrocarbon receptor (Ahr) gene for its toxic effects, such as reproductive disorders in male offspring of maternally exposed rats and mice. To study the involvement of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::729a8c15593b37d0f34fe24abbd7fa81
https://doi.org/10.1095/biolreprod.109.080812

Zobrazit plný text záznamu

Estrogen-responsive genes newly found to be modified by TCDD exposure in human cell lines and mouse systems

Autor: Hiroko Zaha, Ryoiti Kiyama, Junzo Yonemoto, Junko Tanaka, Hideko Sone

Publikováno v: Molecular and Cellular Endocrinology. 272:38-49

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) can induce estrogenic action or inhibit estrogen-induced effects in various tissues because of aryl hydrocarbon receptor (AhR)-estrogen receptor (ER) cross-talk. In order to identify the biomarkers of TCDD e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8011ffd6d1eb20fe1131a94015422b3d
https://doi.org/10.1016/j.mce.2007.04.008

Zobrazit plný text záznamu

Individual Variation of the Genetic Response to Bisphenol A in Human Foreskin Fibroblast Cells Derived from Cryptorchidism and Hypospadias Patients

Autor: Tomokazu Fukuda, Tsutomu Ogata, Jun Yoshinaga, Mami Miyado, Koji Muroya, Hideko Sone, Katsuhiko Ueoka, Yoshiyuki Kojima, Yutaro Hayashi, Hiroko Zaha, Junzo Yonemoto, Maki Fukami, Kentaro Mizuno, Kenjiro Kohri, Aya Hisada, Xian-Yang Qin

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 12, p e52756 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d10c78271def1d8a4efc16b9eb7da9
http://europepmc.org/articles/PMC3532342

Zobrazit plný text záznamu

Identification of Stage-Specific Gene Expression Signatures in Response to Retinoic Acid during the Neural Differentiation of Mouse Embryonic Stem Cells

Autor: Xian-Yang Qin, Hideko Sone, Tin-Tin Win-Shwe, Satoshi Imanishi, Reiko Nagano, Jun Yoshinaga, Tomokazu Fukuda, Hiroko Zaha, Hiromi Akanuma, Seiichiroh Ohsako

Publikováno v: Frontiers in Genetics
Frontiers in Genetics, Vol 3 (2012)

We have previously established a protocol for the neural differentiation of mouse embryonic stem cells (mESCs) as an efficient tool to evaluate the neurodevelopmental toxicity of environmental chemicals. Here, we described a multivariate bioinformati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d64864356c05eadc91f5b730e5f4e2
http://europepmc.org/articles/PMC3413097

Zobrazit plný text záznamu

Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias

Autor: Kenjiro Kohri, Katsuhiko Ueoka, Kentaro Mizuno, Xian-Yang Qin, Masahiro Okura, Claudio Spinelli, Tsutomu Ogata, Hideko Sone, Francesco Massart, Jun Yoshinaga, Junzo Yonemoto, Hiroko Zaha, Yoshiyuki Kojima, Yutaro Hayashi

Publikováno v: Journal of human genetics. 57(7)

We hypothesized that single-nucleotide polymorphisms (SNPs) of genes involved in environmental endocrine disruptors (EEDs) metabolism might influence the risk of male genital malformations. In this study, we explored for association between 384 SNPs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e9da1cbc1217dc82db277aa2d8c61a
https://pubmed.ncbi.nlm.nih.gov/22695890

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání