Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Hiroko Yaguchi"'
Autor:
Anat Melamed, Hiroko Yaguchi, Michi Miura, Aviva Witkover, Tomas W Fitzgerald, Ewan Birney, Charles RM Bangham
Publikováno v:
eLife, Vol 7 (2018)
Chromatin looping controls gene expression by regulating promoter-enhancer contacts, the spread of epigenetic modifications, and the segregation of the genome into transcriptionally active and inactive compartments. We studied the impact on the struc
Externí odkaz:
https://doaj.org/article/9e76d9b49e6546f68be78b0960fb4aac
Autor:
Manuel Eguren, Mónica Álvarez-Fernández, Fernando García, Andrés J. López-Contreras, Kazuyuki Fujimitsu, Hiroko Yaguchi, José Luis Luque-García, Oscar Fernández-Capetillo, Javier Muñoz, Hiroyuki Yamano, Marcos Malumbres
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 670-683 (2014)
The Anaphase-promoting complex/cyclosome (APC/C) cofactor Cdh1 modulates cell proliferation by targeting multiple cell-cycle regulators for ubiquitin-dependent degradation. Lack of Cdh1 results in structural and numerical chromosome aberrations, a ha
Externí odkaz:
https://doaj.org/article/bed4c090d468497d93616232c9fc782a
Autor:
Christy, Prawiro, Tom D, Bunney, Charis, Kampyli, Hiroko, Yaguchi, Matilda, Katan, Charles R M, Bangham
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1869:166601
Development of adult T-cell leukemia/lymphoma (ATL) involves human T-cell leukemia virus type 1 (HTLV-1) infection and accumulation of somatic mutations. The most frequently mutated gene in ATL (36 % of cases) is phospholipase C gamma1 (PLCG1). PLCG1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c95a74fe7b018c706b3eab54d46e4a6
https://doi.org/10.1016/j.bbadis.2022.166601
https://doi.org/10.1016/j.bbadis.2022.166601
Human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of adult T-cell leukaemia/lymphoma (ATL), an aggressive CD4+ T-cell malignancy. The mechanisms of leukaemogenesis in ATL are incompletely understood. Insertional mutagenesis has not pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecaae79b53e9f7eeca82dd99ed0f34e4
http://hdl.handle.net/10044/1/50177
http://hdl.handle.net/10044/1/50177
Publikováno v:
Cancer Science. 102:2097-2102
Germline mutations of the tumor suppressor gene MEN1 are found not only in typical multiple endocrine neoplasia type 1 (MEN1) but also in its incomplete forms such as familial isolated hyperparathyroidism (FIHP) and apparently sporadic parathyroid tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074c2ab7111e799440170abdeffc44ae
https://doi.org/10.1111/j.1349-7006.2011.02055.x
https://doi.org/10.1111/j.1349-7006.2011.02055.x
Autor:
Ichiro Taniuchi, Yoshinori Naoe, Tomoyuki Yamaguchi, Akihiko Kitoh, Masahiro Ono, Naganari Ohkura, Takashi Nomura, Shimon Sakaguchi, Issay Kitabayashi, Toshihiko Tsukada, Hiroko Yaguchi, Yoshiki Miyachi
Publikováno v:
Immunity. 31(4):609-620
SummaryNaturally arising regulatory T (Treg) cells express the transcription factor FoxP3, which critically controls the development and function of Treg cells. FoxP3 interacts with another transcription factor Runx1 (also known as AML1). Here, we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ae30497f76e670f1fc4524eef1a94c
Autor:
Yoshiki Miyachi, Naganari Ohkura, Masahiro Ono, Takashi Nomura, Issay Kitabayashi, Toshihiko Tsukada, Hiroko Yaguchi, Yuko Nagamura, Shimon Sakaguchi
Publikováno v:
Nature. 446:685-689
Naturally arising CD25+CD4+ regulatory T cells (T(R) cells) are engaged in the maintenance of immunological self-tolerance and immune homeostasis by suppressing aberrant or excessive immune responses, such as autoimmune disease and allergy. T(R) cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9162a0f2f78880d9884299b0613d59
https://doi.org/10.1038/nature05673
https://doi.org/10.1038/nature05673
Autor:
Naganari Ohkura, Takao Obara, Toshihiko Tsukada, Yuko Nagamura, Hiroko Yaguchi, Atsushi Fukuuchi
Publikováno v:
Japanese Journal of Clinical Oncology. 36:739-744
Multiple endocrine neoplasia type 1 is an autosomal dominant cancer syndrome characterized by pituitary, parathyroid and enteropancreatic endocrine tumors, which is caused by germline mutations of the tumor suppressor gene MEN1. In the case reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c95b488938a12d2e051e859eb2192e
https://doi.org/10.1093/jjco/hyl089
https://doi.org/10.1093/jjco/hyl089
Autor:
Maho Takahashi, Naganari Ohkura, Yuko Nagamura, Issay Kitabayashi, Toshihiko Tsukada, Hiroko Yaguchi
Publikováno v:
Molecular and Cellular Biology. 24:6569-6580
MEN1 is a tumor suppressor gene that is responsible for multiple endocrine neoplasia type 1 (MEN1) and that encodes a 610-amino-acid protein, called menin. While the majority of germ line mutations identified in MEN1 patients are frameshift and nonse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b8f38887b39cd3f3e9110b5526bdaa
https://doi.org/10.1128/mcb.24.15.6569-6580.2004
https://doi.org/10.1128/mcb.24.15.6569-6580.2004