Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Hiroko Ushikubo"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 2, Pp 72-80 (2017)
We reported that high-mobility group Box-1 (HMGB1) was involved in excitoneurotoxicity in the retina. HMGB1 is known to activate nuclear factor kappa B (NF-κB). However, the role of NF-κB in excitotoxicity is still controversial. Here, we demon
Externí odkaz:
https://doaj.org/article/b4b3ee6293d542bfbbd85d083189269d
Publikováno v:
Journal of Pharmacological Sciences, Vol 129, Iss 2, Pp 107-118 (2015)
Retinal blood flow insufficiency due to capillary loss induces hypoxia in the retina, leading to an abnormal angiogenesis, relating to ischemic retinopathy. To better understand the mechanism and process of retinal capillary regression, we examined t
Externí odkaz:
https://doaj.org/article/aed57f756784424f95a418682b1b2e30
Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats
Autor:
Akane Morita, Kunio Ishii, Daiki Asano, Asami Mori, Tsutomu Nakahara, Hiroko Ushikubo, Kenji Sakamoto, Koki Watanabe
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4439, p 4439 (2021)
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4439, p 4439 (2021)
Metformin, an anti-hyperglycemic drug of the biguanide class, exerts positive effects in several non-diabetes-related diseases. In this study, we aimed to examine the protective effects of metformin against N-methyl-D-aspartic acid (NMDA)-induced exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7cc28acbc00d9863a0c9507ce51bfb
Autor:
Daiki Asano, Kenji Sakamoto, Hiroko Ushikubo, Shiho Arima, Ayuki Nakano, Ryo Kondo, Asami Mori, Kunio Ishii, Tohru Nagamitsu, Tsutomu Nakahara
Publikováno v:
Experimental Eye Research. 168:115-127
A short-term blockade of the vascular endothelial growth factor (VEGF)-mediated pathway in neonatal rats results in formation of severe retinopathy of prematurity (ROP)-like retinal blood vessels. The present study aimed to examine the role of retina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101a8b82a4fa82f55079897972bf516b
https://doi.org/10.1016/j.exer.2017.12.007
https://doi.org/10.1016/j.exer.2017.12.007
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 2, Pp 72-80 (2017)
We reported that high-mobility group Box-1 (HMGB1) was involved in excitoneurotoxicity in the retina. HMGB1 is known to activate nuclear factor kappa B (NF-κB). However, the role of NF-κB in excitotoxicity is still controversial. Here, we demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84a3db279c49f650aa445acc4bb4bf7
http://www.sciencedirect.com/science/article/pii/S1347861317301627
http://www.sciencedirect.com/science/article/pii/S1347861317301627
Autor:
Akane Morita, Kunio Ishii, Asami Mori, Tohru Nagamitsu, Tsutomu Nakahara, Kenji Sakamoto, Shiho Arima, Hiroko Ushikubo
Publikováno v:
Developmental Dynamics. 246:186-200
Background: Astrocytes migrate into the retina through the optic nerve head via the axons of retinal ganglion cells, and spread radially towards the peripheral retina. Endothelial cells migrate along the astrocyte cellular network to form the retinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b391124da92e4e980f5301aa86a1948
https://doi.org/10.1002/dvdy.24484
https://doi.org/10.1002/dvdy.24484
Autor:
Hiroko Ushikubo, Yuta Murakami, Kunio Ishii, Kenji Sakamoto, Tsutomu Nakahara, Shohei Sawada, Asami Mori
Publikováno v:
European Journal of Pharmacology. 791:213-220
Retinal ganglion cell death in glaucoma is caused at least in part by a large Ca2+ influx through N-methyl-D-aspartic acid (NMDA) receptors. Apelin is a peptide originally found in the tissue extracts of bovine stomach. Recent studies have been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1748b6f1f92f3190cc893418c9953e
https://doi.org/10.1016/j.ejphar.2016.08.036
https://doi.org/10.1016/j.ejphar.2016.08.036
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 107:216-224
The interruption of vascular development could cause structural and functional abnormalities in tissues. We have previously reported that short-term treatment of newborn mice with vascular endothelial growth factor (VEGF) receptor tyrosine kinase inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44a6d5342036f434010af68cdc5528b7
https://doi.org/10.1002/bdrb.21187
https://doi.org/10.1002/bdrb.21187
Publikováno v:
Journal of Pharmacological Sciences, Vol 129, Iss 2, Pp 107-118 (2015)
Retinal blood flow insufficiency due to capillary loss induces hypoxia in the retina, leading to an abnormal angiogenesis, relating to ischemic retinopathy. To better understand the mechanism and process of retinal capillary regression, we examined t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d201ca7c43c1c9e5b29ed99397b4cd
http://www.sciencedirect.com/science/article/pii/S1347861315001930
http://www.sciencedirect.com/science/article/pii/S1347861315001930
Autor:
Tomohiro Asakawa, Toshiyuki Kan, Yui Tanimoto, Kazuho Abe, Hiroko Ushikubo, Tatsuhiro Akaishi
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:748-754
Amyloid β protein (Aβ) self-assembles into insoluble fibrils, and forms the senile plaques associated with Alzheimer's disease. 3,3',4',5'-Tetrahydroxyflavone, a synthetic analogue of the natural flavonoid fisetin, has been found to potently inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4c6b1ae5df54d5d546cde49262c901
https://doi.org/10.1248/bpb.b13-00709
https://doi.org/10.1248/bpb.b13-00709