Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hiroko Tsuruta"'
Autor:
Hiroko Tsuruta, Christopher J Paddon, Diana Eng, Jacob R Lenihan, Tizita Horning, Larry C Anthony, Rika Regentin, Jay D Keasling, Neil S Renninger, Jack D Newman
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4489 (2009)
BackgroundArtemisinin derivatives are the key active ingredients in Artemisinin combination therapies (ACTs), the most effective therapies available for treatment of malaria. Because the raw material is extracted from plants with long growing seasons
Externí odkaz:
https://doaj.org/article/29329a6165654224a54f2846107a793c
Publikováno v:
Biotechnology Progress. 24:1026-1032
Artemisinin-based combination therapies (ACTs) are currently unaffordable for many of the people who need them most. A major cost component of ACTs is the plant-derived artemisinin. A fermentation process for a precursor to artemisinin might provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc6802274d0077559c2cccc344500a2
https://doi.org/10.1002/btpr.27
https://doi.org/10.1002/btpr.27
Publikováno v:
Journal of Industrial Microbiology & Biotechnology. 33:445-453
Various bioactive small molecules produced by microbial cultivation are degraded in the culture broth or may repress the formation of additional product. The inclusion of hydrophobic adsorber resin beads to capture these products in situ and remove t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492f173b64df2d2ebb73019f1fd3e407
https://doi.org/10.1007/s10295-006-0088-1
https://doi.org/10.1007/s10295-006-0088-1
Publikováno v:
Biotechnology Progress. 21:1102-1108
Epothilone D is a member of a class of potent antineoplastic natural products produced by myxobacteria. Previously, we have described a fed-batch epothilone D production process in which an adsorber resin is incorporated into the bioreactor setup to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5254dec9f86470b70adab0d1fb85b71
https://doi.org/10.1021/bp050010+
https://doi.org/10.1021/bp050010+
Autor:
Janice Lau, Rika Regentin, Christopher D. Reeves, Daniel V. Santi, Scott Frykman, Hiroko Tsuruta, Sally Ou, Peter J. Licari, John R. Carney
Publikováno v:
Journal of Industrial Microbiology & Biotechnology. 28:17-20
Recently, the epothilone polyketide synthase (PKS) was successfully introduced into a heterologous production host for the large-scale production of epothilone D. We have found that at least three other epothilones can also be produced as the major f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031f21a259d7ff834fa6199b5f106950
https://doi.org/10.1038/sj.jim.7000209
https://doi.org/10.1038/sj.jim.7000209
Autor:
David J. Melis, Michael D. Leavell, Chris J. Paddon, Diana Eng, Tizita Horning, Jack D. Newman, Neil Stephen Renninger, Jay D. Keasling, Jacob R. Lenihan, Patrick J. Westfall, Rika Regentin, Derek McPhee, Andrew Owens, Frank X. Woolard, Kirsten R. Benjamin, Scott Fickes, Don Diola, Douglas J. Pitera, Hiroko Tsuruta
Publikováno v:
Proceedings of the National Academy of Sciences. 109
Malaria, caused by Plasmodium sp , results in almost one million deaths and over 200 million new infections annually. The World Health Organization has recommended that artemisinin-based combination therapies be used for treatment of malaria. Artemis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3795724f56b96b08013cbfd35bfacf3f
https://doi.org/10.1073/pnas.1110740109
https://doi.org/10.1073/pnas.1110740109
Autor:
Diana Eng, Tizita Horning, Christopher J. Paddon, Larry Cameron Anthony, Jacob R. Lenihan, Jack D. Newman, Jay D. Keasling, Neil Stephen Renninger, Rika Regentin, Hiroko Tsuruta
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4489 (2009)
PloS one, vol 4, iss 2
PLoS ONE
PloS one, vol 4, iss 2
PLoS ONE
BackgroundArtemisinin derivatives are the key active ingredients in Artemisinin combination therapies (ACTs), the most effective therapies available for treatment of malaria. Because the raw material is extracted from plants with long growing seasons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9178d7938d7060ee3a072a5964abf67f
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19221601/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19221601/?tool=EBI
Publikováno v:
Biotechnology progress. 21(4)
Epothilone D is a member of a class of potent antineoplastic natural products produced by myxobacteria. Previously, we have described a fed-batch epothilone D production process in which an adsorber resin is incorporated into the bioreactor setup to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::374db208afdf16efacf37742441a8857
https://pubmed.ncbi.nlm.nih.gov/16080689
https://pubmed.ncbi.nlm.nih.gov/16080689
Publikováno v:
Biotechnology and bioengineering. 78(3)
The heterologous production of epothilone D in Myxococcus xanthus was improved by 140-fold from an initial titer of 0.16 mg/L with the incorporation of an adsorber resin, the identification of a suitable carbon source, and the implementation of a fed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3667ee82b6c593dfdb7cacd0e1655cc
https://pubmed.ncbi.nlm.nih.gov/11920444
https://pubmed.ncbi.nlm.nih.gov/11920444