Zobrazeno 1 - 10
of 291
pro vyhledávání: '"Hiroko Togashi"'
Autor:
Hiroki Shikanai, Nobuhiro Oshima, Hidekazu Kawashima, Shin‐ichi Kimura, Sachiko Hiraide, Hiroko Togashi, Kenji Iizuka, Kazue Ohkura, Takeshi Izumi
Publikováno v:
Neuropsychopharmacology Reports, Vol 38, Iss 2, Pp 61-66 (2018)
Abstract Aim We previously reported that stroke‐prone spontaneously hypertensive rat/Ezo (SHRSP/Ezo) has high validity as an attention deficit/hyperactivity disorder (AD/HD) animal model, based on its behavioral phenotypes, such as inattention, hyp
Externí odkaz:
https://doaj.org/article/9dc426ae6e4546fc97d46f424995a435
Autor:
Sumitaka Inoue, Hiroki Shikanai, Machiko Matsumoto, Sachiko Hiraide, Yasuhiro Saito, Yoshiki Yanagawa, Mitsuhiro Yoshioka, Kei-ichi Shimamura, Hiroko Togashi
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 3, Pp 394-407 (2014)
Gender differences in psychiatric disorders are considered to be associated with the serotonergic (5-HTergic) system; however the underlying mechanisms have not been clearly elucidated. In this study, possible involvement of the median raphe nucleus
Externí odkaz:
https://doaj.org/article/6fa12f9d0c5d42a6b77357505c060299
Autor:
Sumitaka Inoue, Hidekazu Kamiyama, Machiko Matsumoto, Yoshiki Yanagawa, Sachiko Hiraide, Yasuhiro Saito, Kei-ichi Shimamura, Hiroko Togashi
Publikováno v:
Journal of Pharmacological Sciences, Vol 123, Iss 3, Pp 267-278 (2013)
The present study elucidated the functional role of modulatory effects of basolateral amygdala (BLA) on synaptic transmission in the rat hippocampus–medial prefrontal cortex (mPFC) pathway, compared with the hippocampal dentate gyrus (DG). Exposure
Externí odkaz:
https://doaj.org/article/6b2cc9afbba3456ab25c3e370034211b
Autor:
Sachiko Hiraide, Yasuhiro Saito, Machiko Matsumoto, Yoshiki Yanagawa, Shuhei Ishikawa, Yasunori Kubo, Sumitaka Inoue, Mitsuhiro Yoshioka, Hiroko Togashi
Publikováno v:
Journal of Pharmacological Sciences, Vol 119, Iss 1, Pp 64-72 (2012)
Several lines of evidence have shown that early life experiences have a profound impact on fear-related behavior, but the detailed mechanisms are unknown. The present study examined the possible involvement of the amygdala in behavioral deficits asso
Externí odkaz:
https://doaj.org/article/9f56aa24aedb465b958649d3ed26cc81
Autor:
Jin Kakehata, Taku Yamaguchi, Hiroko Togashi, Ichiro Sakuma, Hiroshi Otani, Yuji Morimoto, Mitsuhiro Yoshioka
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 2, Pp 189-197 (2010)
We performed this study to elucidate whether a newly developed liposome-encapsulated hemoglobin, TRM-645 (TRM), can prevent cerebral dysfunction resulting from acute ischemic stroke when used as an oxygen carrier. Hippocampal long-term potentiation (
Externí odkaz:
https://doaj.org/article/b69e28522eda4275aaf57e3d49043f4f
Autor:
Hiroki Shikanai, Takeshi Izumi, Machiko Matsumoto, Hiroko Togashi, Taku Yamaguchi, Takayuki Yoshida, Mitsuhiro Yoshioka
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 3, Pp 341-346 (2010)
Abstract.: The medial prefrontal cortex (mPFC) has recently been shown to be an important brain region for emotional function as well as cognitive ability. In previous experiments, we studied the population spike amplitude (PSA) in the mPFC induced b
Externí odkaz:
https://doaj.org/article/29297f1a87594f9aa45342d4861e84b2
Autor:
Naobumi Hamadate, Taku Yamaguchi, Aya Sugawara, Hiroko Togashi, Takeshi Izumi, Takayuki Yoshida, Yu Ohmura, Mitsuhiro Yoshioka
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 4, Pp 409-419 (2010)
Abstract.: Liposome-encapsulated hemoglobin (LEH) has been developed as a blood substitute. In spite of its size (1/30 – 1/40 of erythrocytes), LEH has an oxygen-carrying capacity comparable to erythrocytes. Thus, LEH is expected to carry oxygen in
Externí odkaz:
https://doaj.org/article/cea3b94c19b74a34ae8de8aaefbf4656
Autor:
Hiroshi Otani, Subrina Jesmin, Hiroko Togashi, Ichiro Sakuma, Kunihiko Nakai, Hiroshi Satoh, Mitsuhiro Yoshioka, Akira Kitabatake
Publikováno v:
Journal of Pharmacological Sciences, Vol 96, Iss 2, Pp 188-198 (2004)
Evidence suggests that S-nitrosylation is a biological process involved in cerebral ischemia. The aim of the present study was to elucidate the effects of S-nitrosylated (SNO) polyethylene glycol-conjugated (PEG) hemoglobin (Hb) developed as an artif
Externí odkaz:
https://doaj.org/article/01820efe928a4cdaae0bc7c0c6f22b53
Publikováno v:
Journal of Pharmacological Sciences, Vol 93, Iss 4, Pp 451-457 (2003)
ABSTRACT: Repetitive transcranial magnetic stimulation (rTMS) changes the function of the cortex. This study clarified the effects of acute rTMS treatment on extracellular serotonin (5-HT) concentrations in the rat prefrontal cortex (PFC) by using in
Externí odkaz:
https://doaj.org/article/4ae9d6df3d3e49aebab68051d8e70725
Autor:
Satoshi Ohashi, Hiroko Togashi, Machiko Matsumoto, Kiyoshi Mori, Ken-ichi Ueno, Mitsuhiro Yoshioka
Publikováno v:
Journal of Pharmacological Sciences, Vol 92, Iss 2, Pp 100-107 (2003)
There is evidence indicating that dysregulation of coordinated interactions of the cortical-limbic circuitry is associated with anxiety and mood disorders. Our previous study has reported that an enhancement of long-term plasticity in the “limbic-c
Externí odkaz:
https://doaj.org/article/d3f1fb4658fa47e3ad7a9ab331c89ed0