Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Hiroko Miyagishi"'
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-15 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. The pathogenesis of ALS remains largely unknown; however, inflammation of the spinal cor
Externí odkaz:
https://doaj.org/article/58edada272b149438fa2905039dfd621
Autor:
Naoto Suzuki, Hiroaki Tanigawa, Taiki Nagatomo, Hiroko Miyagishi, Takanori Kanazawa, Toyofumi Suzuki, Yasuhiro Kosuge
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2553 (2023)
Intranasal administration has attracted attention as a means of delivering drugs because it bypasses the blood–brain barrier. However, conventional intranasal administration of drug solutions to mice using the micropipette method (MP method) is com
Externí odkaz:
https://doaj.org/article/a52a46c2505d4194a1059dbb5697b4af
Autor:
Komugi Tsuruta, Takato Shidara, Hiroko Miyagishi, Hiroshi Nango, Yoshihiko Nakatani, Naoto Suzuki, Taku Amano, Toyofumi Suzuki, Yasuhiro Kosuge
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13698 (2023)
Neuroinflammation is a fundamental feature in the pathogenesis of amyotrophic lateral sclerosis (ALS) and arises from the activation of astrocytes and microglial cells. Previously, we reported that Miyako Bidens pilosa extract (MBP) inhibited microgl
Externí odkaz:
https://doaj.org/article/619d5bbdb66843daadb5a00d77cbbabd
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 7, Iss 4, Pp 371-374 (2017)
Chronic stress is widely recognized as a risk factor for the development of major depression and anxiety disorders. Recently, we reported that yokukansan (YKS), a traditional Japanese herbal medicine, alleviated emotional abnormality in stress-malada
Externí odkaz:
https://doaj.org/article/3bdf1b3be758497186c092559b9f5913
Autor:
Hiroshi Nango, Yasuhiro Kosuge, Hiroko Miyagishi, Kosuke Sugawa, Yoshihisa Ito, Kumiko Ishige
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 2, Pp 64-71 (2017)
Prostaglandin E2 (PGE2) exerts various biological effects by binding to E-prostanoid receptors (EP1-4). Although recent studies have shown that PGE2 induces cell differentiation in some neuronal cells such as mouse DRG neurons and sensory neuron-like
Externí odkaz:
https://doaj.org/article/191ccc3a1bf24d9588cb3081d54d24ac
Autor:
Hiroshi Nango, Yasuhiro Kosuge, Nana Yoshimura, Hiroko Miyagishi, Takanori Kanazawa, Kaname Hashizaki, Toyofumi Suzuki, Kumiko Ishige
Publikováno v:
Cells, Vol 9, Iss 4, p 934 (2020)
Prostaglandins are a group of physiologically active lipid compounds derived from arachidonic acid. Our previous study has found that prostaglandin E2 promotes neurite outgrowth in NSC-34 cells, which are a model for motor neuron development. However
Externí odkaz:
https://doaj.org/article/bda67fc87856413f85c164abded13a7f
Autor:
Hiroko Miyagishi, Yasuhiro Kosuge, Yuki Yoneoka, Maiko Ozone, Manami Endo, Nobuhiro Osada, Kumiko Ishige, Kuniko Kusama-Eguchi, Yoshihisa Ito
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 4, Pp 347-350 (2013)
Abstract.: Prostaglandin E2 (PGE2) was shown to induce neuronal death in the CNS. To characterize the neurotoxicity of PGE2 and E-prostanoid receptors (EP) in motor neurons, we investigated PGE2-induced cell death and the type(s) of EP responsible fo
Externí odkaz:
https://doaj.org/article/fdbaf0e72e82462baa8525f752806747
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 2, Pp 225-236 (2012)
Prostaglandin E2 (PGE2) is a key molecule involved in the neuroinflammatory processes that characterize amyotrophic lateral sclerosis (ALS). Although PGE2 synthesis is regulated by PGE2 synthases (PGESs), the pathological role of PGESs in ALS still r
Externí odkaz:
https://doaj.org/article/2ff9e93bd0714ef2a2f0a481e8badb2d
Autor:
Hiroki Kasai, Kumiko Ishige, Yoshihisa Ito, Yasuhiro Kosuge, Takayuki Mawatari, Hiroko Miyagishi, Kenta Nishiyama, Hiroshi Nango, Takuya Yanagi
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease characterized by progressive degeneration of motor neurons in the central nervous system. Prostaglandin E2 (PGE2) plays a pivotal role in the degeneration of motor neurons in h
Autor:
Hiroko, Miyagishi, Minoru, Tsuji, Kazuya, Miyagawa, Kazuhiro, Kurokawa, Atsumi, Mochida-Saito, Kohei, Takahashi, Yasuhiro, Kosuge, Kumiko, Ishige, Hiroshi, Takeda
Publikováno v:
Brain research. 1783
The ability to adapt to stress is an essential defensive function of a living body, and disturbance of this ability in the brain may contribute to the development of affective illness. Previously, we reported that mice exposed to unadaptable restrain