Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hiroko Kimoto"'
Autor:
Takuya Osakada, Takayuki Abe, Takumi Itakura, Hiromi Mori, Kentaro K. Ishii, Ryo Eguchi, Ken Murata, Kosuke Saito, Sachiko Haga-Yamanaka, Hiroko Kimoto, Yoshihiro Yoshihara, Kazunari Miyamichi, Kazushige Touhara
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The vomeronasal system regulates sensing of various environmental cues. Here, the authors show that exposure to hemoglobin results in the activation of Vmn2r88+ vomeronasal sensory neurons in both male and female mice. However, exposure to hemoglobin
Externí odkaz:
https://doaj.org/article/d2930fc6fc86483cb9ee8ddadee92e36
Autor:
Narayan Karanjule, Noriyuki Hayashi, Sayaka Suzuki, Toshifumi Tsuda, Eri Tokumaru, Kyosuke Tanaka, Hiroko Kimoto, Yuki Domon, Sakiko Takahashi, Kazufumi Kubota, Yutaka Kitano, Tomihisa Yokoyama, Ryuta Koishi, Chie Fujiwara, Shinichi Inaba, Daigo Asano, Tomoko Sakakura, Kiyoshi Takasuna, Tsuyoshi Shinozuka
Publikováno v:
ACS Medicinal Chemistry Letters.
Autor:
Yutaka Kitano, Chie Fujiwara, Sayaka Suzuki, Ryuta Koishi, Tomihisa Yokoyama, Satoshi Shibuya, Daigo Asano, Yuki Domon, Kyosuke Tanaka, Hiroko Kimoto, Akiko Shimizugawa, Tsuyoshi Shinozuka, Kazufumi Kubota, Hiroyuki Kobayashi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:653-663
The discovery of a novel class of state-dependent voltage-gated sodium channel (NaV)1.7 inhibitors is described. By the modification of amide or urethane bond in NaV1.7 blocker III, structure-activity relationship studies that led to the identificati
Autor:
Tomihisa Yokoyama, Sakiko Takahashi, Kiyoshi Takasuna, Noriyuki Hayashi, Hiroyuki Kobayashi, Ryuta Koishi, Chie Fujiwara, Eri Tokumaru, Yasuyuki Abe, Kyosuke Tanaka, Sayaka Suzuki, Kazufumi Kubota, Daigo Asano, Narayan Karanjule, Tsuyoshi Shinozuka, Masahiro Inoue, Hiroko Kimoto, Tsuda Toshifumi, Yutaka Kitano, Kiyono Ueda, Toshiyuki Watanabe, Yuki Domon, Tomoko Sakakura, Akiko Shimizugawa
Publikováno v:
Journal of Medicinal Chemistry. 63:10204-10220
A highly potent, selective NaV1.7 inhibitor, DS-1971a, has been discovered. Exploration of the left-hand phenyl ring of sulfonamide derivatives (I and II) led to the discovery of novel series of cycloalkane derivatives with high NaV1.7 inhibitory pot
Autor:
Kyosuke, Tanaka, Hiroyuki, Kobayashi, Sayaka, Suzuki, Satoshi, Shibuya, Hiroko, Kimoto, Yuki, Domon, Kazufumi, Kubota, Yutaka, Kitano, Tomihisa, Yokoyama, Akiko, Shimizugawa, Ryuta, Koishi, Chie, Fujiwara, Daigo, Asano, Tsuyoshi, Shinozuka
Publikováno v:
Chemicalpharmaceutical bulletin. 68(7)
The discovery of a novel class of state-dependent voltage-gated sodium channel (Na
Autor:
Tsuyoshi, Shinozuka, Hiroyuki, Kobayashi, Sayaka, Suzuki, Kyosuke, Tanaka, Narayan, Karanjule, Noriyuki, Hayashi, Toshifumi, Tsuda, Eri, Tokumaru, Masahiro, Inoue, Kiyono, Ueda, Hiroko, Kimoto, Yuki, Domon, Sakiko, Takahashi, Kazufumi, Kubota, Tomihisa, Yokoyama, Akiko, Shimizugawa, Ryuta, Koishi, Chie, Fujiwara, Daigo, Asano, Tomoko, Sakakura, Kiyoshi, Takasuna, Yasuyuki, Abe, Toshiyuki, Watanabe, Yutaka, Kitano
Publikováno v:
Journal of medicinal chemistry. 63(18)
A highly potent, selective Na
Autor:
Takuya Osakada, Takayuki Abe, Takumi Itakura, Hiromi Mori, Kentaro K. Ishii, Ryo Eguchi, Ken Murata, Kosuke Saito, Sachiko Haga-Yamanaka, Hiroko Kimoto, Yoshihiro Yoshihara, Kazunari Miyamichi, Kazushige Touhara
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The vomeronasal system plays an essential role in sensing various environmental chemical cues. Here we show that mice exposed to blood and, consequently, hemoglobin results in the activation of vomeronasal sensory neurons expressing a specific vomero
Publikováno v:
Pure and Applied Chemistry. 79:775-783
Pheromonal signals received by the vomeronasal organ (VNO) have been shown to elicit various behavioral and physiological responses that are typically stereotyped and preprogrammed. Recently, we found a novel male-specific peptide, named exocrine gla
Autor:
Tomihisa Yokoyama, Hiroko Kimoto, Daigo Asano, Ryusuke Sugita, Kazufumi Kubota, Ryuta Koishi, Takeshi Kuroda, Yuki Domon, Akiko Shimizugawa, Sayaka Suzuki, Kazuhiko Tamaki, Yutaka Kitano, Tsuyoshi Shinozuka, Hiroyuki Kobayashi
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(22)
A novel class of NaV1.7 inhibitors has been identified by high-throughput screening followed by structure activity relationship studies. Among this series of compounds, piperidine 9o showed potent human and mouse NaV1.7 inhibitory activities with fai
Autor:
Hiroko KIMOTO
Publikováno v:
Journal of Japan Association on Odor Environment. 36:141-143