Inositol 1,4,5‐trisphosphate receptor determines intracellular Ca2+ concentration in Trypanosoma cruzi throughout its life cycle

Autor: Muneaki Hashimoto, Motomichi Doi, Nagomi Kurebayashi, Koji Furukawa, Hiroko Hirawake‐Mogi, Yoshihiro Ohmiya, Takashi Sakurai, Toshihiro Mita, Katsuhiko Mikoshiba, Takeshi Nara

Publikováno v: FEBS Open Bio, Vol 6, Iss 12, Pp 1178-1185 (2016)

Regulation of intracellular Ca2+ concentration ([Ca2+]i) is vital for eukaryotic organisms. Recently, we identified a Ca2+ channel (TcIP3R) associated with intracellular Ca2+ stores in Trypanosoma cruzi, the parasitic protist that causes Chagas disea

Externí odkaz: https://doaj.org/article/de8994074b064fe78e98f4c51fd4e836

RNA-recognition motifs and glycine and arginine-rich region cooperatively regulate the nucleolar localization of nucleolin

Autor: Hiroko Hirawake-Mogi, Mitsuru Okuwaki, Ai Saotome-Nakamura, Takeshi Sekiya, Kyosuke Nagata, Shoko Saito, Masashi Yoshimura

Publikováno v: The Journal of Biochemistry. 169:87-100

Nucleolin (NCL) is a nucleolar protein i.e. involved in the regulation of the nucleolar structure and functions, and consists of three distinct regions: the N-terminal region; the middle region, which contains four RNA-recognition motifs (RRMs); and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8ef90a7fe14570552b6b35679982f3
https://doi.org/10.1093/jb/mvaa095

The interaction between nucleophosmin/NPM1 and the large ribosomal subunit precursors contribute to maintaining the nucleolar structure

Autor: Kyosuke Nagata, Hiroko Hirawake-Mogi, Mitsuru Okuwaki, Shoko Saito

Publikováno v: Biochimica et biophysica acta. Molecular cell research. 1868(1)

Nucleoli are sites where both the large and small ribosomal subunits mature. Biochemical assays have suggested that a multivalent nucleolar protein, NPM1/nucleophosmin contributes to the formation of the outer layer of the nucleolus. Prior works show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28aa1939d554cd67da3e885a410cc134
https://pubmed.ncbi.nlm.nih.gov/33039556

Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids

Autor: Takashi Makiuchi, Muneaki Hashimoto, Hikari Taka, Tom A. Williams, Naoko Kaga, T. Martin Embley, Hiroko Hirawake-Mogi, Jorge Morales, Juan Luis Concepción, Toshihiro Mita, Takeshi Nara, Frédéric Bringaud, Tetsuo Hashimoto, Tsutomu Fujimura, Akiko Tsubouchi, Masato Koike

Publikováno v: Morales, J, Hashimoto, M, Williams, T, Hirawake-Mogi, H, Makiuchi, T, Tsubouchi, A, Kaga, N, Taka, H, Fujimura, T, Koike, M, Mita, T, Bringaud, F, Concepción, J L, Hashimoto, T, Embley, T M & Nara, T 2016, ' Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids ', Proceedings of the Royal Society B: Biological Sciences, vol. 283, no. 1830 . https://doi.org/10.1098/rspb.2016.0520

The remodelling of organelle function is increasingly appreciated as a central driver of eukaryotic biodiversity and evolution. Kinetoplastids including Trypanosoma and Leishmania have evolved specialized peroxisomes, called glycosomes. Glycosomes un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0ce85d8248b2bccfc8ef95052215fb
https://pubmed.ncbi.nlm.nih.gov/27170716

Novel Mitochondrial Complex II Isolated from Trypanosoma cruzi Is Composed of 12 Peptides Including a Heterodimeric Ip Subunit

Autor: Tatsushi Mogi, Jorge Morales, Kimitoshi Sakamoto, Shigeru Mineki, Hiroko Hirawake, Eizo Takashima, Kiyoshi Kita, Reiko Mineki, Satoshi Ōmura

Publikováno v: Journal of Biological Chemistry. 284:7255-7263

Mitochondrial respiratory enzymes play a central role in energy production in aerobic organisms. They differentiated from the α-proteobacteria-derived ancestors by adding noncatalytic subunits. An exception is Complex II (succinate: ubiquinone reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae620953a125bc84c8e2e388d4d9132c
https://doi.org/10.1074/jbc.m806623200