Výsledky vyhledávání - "Hiroko Habuchi"

Akademický článek

A novel mice model of acute flares in osteoarthritis elicited by intra‐articular injection of cultured mast cells

Autor: Junpei Dan, Masashi Izumi, Hiroko Habuchi, Osami Habuchi, Shogo Takaya, Yusuke Kasai, Ryuzo Hayashi, Koji Aso, Takahiro Ushida, Masahiko Ikeuchi

Publikováno v: Journal of Experimental Orthopaedics, Vol 8, Iss 1, Pp n/a-n/a (2021)

Abstract Purpose Mast cells are multifunctional in osteoarthritis (OA), and infiltration of activated mast cells likely contributes to disease severity and progression. However, the detailed mechanisms of action are unclear. The purpose of this study

Externí odkaz: https://doaj.org/article/0183d08af3e942559ea499ebe70541ef

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Akademický článek

Bone marrow derived mast cells injected into the osteoarthritic knee joints of mice induced by sodium monoiodoacetate enhanced spontaneous pain through activation of PAR2 and action of extracellular ATP.

Autor: Hiroko Habuchi, Masashi Izumi, Junpei Dan, Takahiro Ushida, Masahiko Ikeuchi, Kosei Takeuchi, Osami Habuchi

Publikováno v: PLoS ONE, Vol 16, Iss 6, p e0252590 (2021)

Conditions that resemble osteoarthritis (OA) were produced by injection of sodium monoiodoacetate (MIA) into the knee joints of mice. Bone marrow derived mast cells (BMMCs) injected into the OA knee joints enhanced spontaneous pain. Since no spontane

Externí odkaz: https://doaj.org/article/70ea39fd51374150b3f44cd5cc92de50

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Akademický článek

Mice deficient in N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase exhibit enhanced liver fibrosis and delayed recovery from fibrosis in carbon tetrachloride-treated mice

Autor: Hiroko Habuchi, Takahiro Ushida, Osami Habuchi

Publikováno v: Heliyon, Vol 2, Iss 8 (2016)

Background: Chondroitin/dermatan sulfate (CS/DS) rich in N-acetylgalactosamine 4,6-bissulfate (GalNAc(4,6SO4)) residues is present as decorin and/or biglycan in mouse liver, and GalNAc(4,6SO4) residues disappeared completely in N-acetylgalactosamine

Externí odkaz: https://doaj.org/article/b7cf3c5cb906461f8f8dee53cc20decf

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A novel mice model of acute flares in osteoarthritis elicited by intra-articular injection of cultured mast cells

Autor: Shogo Takaya, Ryuzo Hayashi, Yusuke Kasai, Koji Aso, Osami Habuchi, Masahiko Ikeuchi, Takahiro Ushida, Junpei Dan, Hiroko Habuchi, Masashi Izumi

Publikováno v: Journal of Experimental Orthopaedics, Vol 8, Iss 1, Pp 1-11 (2021)
Journal of Experimental Orthopaedics

Purpose Mast cells are multifunctional in osteoarthritis (OA), and infiltration of activated mast cells likely contributes to disease severity and progression. However, the detailed mechanisms of action are unclear. The purpose of this study was to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00b23e769839e0f25bdd6e40ce5765f
https://doi.org/10.1186/s40634-021-00391-6

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Autor: Kosei Takeuchi, Osami Habuchi, Masahiko Ikeuchi, Junpei Dan, Takahiro Ushida, Hiroko Habuchi, Masashi Izumi

Publikováno v: PLoS ONE, Vol 16, Iss 6, p e0252590 (2021)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f099acd4ad47d51f30b577bb9e29006f
https://doaj.org/article/70ea39fd51374150b3f44cd5cc92de50

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Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3

Autor: Craig Freeman, Oleg Federov, Hideaki Nagase, Christopher Lazenbatt, Osami Habuchi, Hiroko Habuchi, Md. Ferdous Anower-E-Khuda, Linda Troeberg, Koji Kimata

Publikováno v: Chemistry & Biology

Summary Tissue inhibitor of metalloproteinase 3 (TIMP-3) is an important regulator of extracellular matrix (ECM) turnover. TIMP-3 binds to sulfated ECM glycosaminoglycans or is endocytosed by cells via low-density lipoprotein receptor-related protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce63a91284eaede5e7120283fd6f6bd9

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Involvement of heparan sulfate 6-O-sulfation in the regulation of energy metabolism and the alteration of thyroid hormone levels in male mice

Autor: Hiroko Habuchi, Toru Imamura, Naoko Nagai, Masao Nakamura, Hideto Watanabe, Noriko Sugaya, Koji Kimata

Publikováno v: Glycobiology. 23:980-992

Here, we report that male heparan sulfate 6-O-sulfotransferase-2 (Hs6st2) knockout mice showed increased body weight in an age-dependent manner even when fed with a normal diet and showed a phenotype of impaired glucose metabolism and insulin resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8b3305743f48c5bab1d1e9ac9bb152
https://doi.org/10.1093/glycob/cwt037

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Heparan Sulfate 6-O-Sulfotransferase Isoform-dependent Regulatory Effects of Heparin on the Activities of Various Proteases in Mast Cells and the Biosynthesis of 6-O-Sulfated Heparin

Autor: Koji Kimata, Naoko Nagai, Osami Habuchi, Takashi Yokochi, Hiroko Habuchi, Md. Ferdous Anower-E-Khuda

Publikováno v: Journal of Biological Chemistry. 288:3705-3717

Heparan sulfate 6-O-sulfotransferase (HS6ST) is an enzyme involved in heparan sulfate (HS) biosynthesis that transfers a sulfate residue to position 6 of the GlcNAc/GlcNSO3 residues of HS, and it consists of three isoforms. Heparin, the highly sulfat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2b2eda1dae1b167ca963ef89782918
https://doi.org/10.1074/jbc.m112.416651

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Heparan sulfate 6-O-sulfotransferase 1 , a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism

Autor: Nelly Pitteloud, Hiroko Habuchi, Stan Van Uum, Virginia A. Hughes, Lacey Plummer, Kimberly Keefe, Guy Van Vliet, Gerasimos P. Sykiotis, Janet E. Hall, William F. Crowley, Stephanie B. Seminara, Xuan Hoang, Hannes E. Bülow, Koji Kimata, Janne Tornberg, Richard Quinton

Publikováno v: Proceedings of the National Academy of Sciences. 108:11524-11529

Neuronal development is the result of a multitude of neural migrations, which require extensive cell-cell communication. These processes are modulated by extracellular matrix components, such as heparan sulfate (HS) polysaccharides. HS is molecularly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770008e73cceef83d2ea2e04422d2091
https://doi.org/10.1073/pnas.1102284108

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Functional analysis of chick heparan sulfate 6-O-sulfotransferases in limb bud development

Autor: Ken Nogami, Hiroko Habuchi, Hiroyuki Ide, Koji Tamura, Satoko Ashikari-Hada, Takashi Kobayashi, Koji Kimata

Publikováno v: Development, Growth & Differentiation. 52:146-156

Heparan sulfate (HS) interacts with numerous growth factors, morphogens, receptors, and extracellular matrix proteins. Disruption of HS synthetic enzymes causes perturbation of growth factor signaling and malformation in vertebrate and invertebrate d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::407a451781e21996dbae09a4154d1dbe
https://doi.org/10.1111/j.1440-169x.2009.01148.x

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