Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Hiroko Akiyoshi"'
Autor:
Yoichiro Ogama, Yuji Kumagai, Norio Komatsu, Marito Araki, Nami Masubuchi, Hiroko Akiyoshi, Tadashi Matsuura, Hiromi Kirisako, Akiko Kyoya, Fumiko Nomura, Yuta Ohira, Takuya Yokokawa, Yukiya Yamamoto
Publikováno v:
Clinical Pharmacology in Drug Development.
This study aimed to evaluate the safety, pharmacokinetics, and pharmacodynamics of PPMX-T003, a novel human monoclonal antibody for transferrin receptor 1 (TFR1), in healthy individuals. Forty participants were enrolled and randomized to PPMX-T003 do
Autor:
Maria Luisa Della Bona, Jianjun Ou, Joanne Marjason, Akito Tanaka, Guang-Dong Sun, Melania Falchi, Takayuki Nemoto, Ye Jia, Shengzi Wang, Li-Ning Miao, Hiroyuki Watanabe, Shirin Bruderer, Nianzu Chen, Yamin Li, Takayoshi Ohba, Meixian Ou, Manabu Murakami, Jasper Dingemanse, Changjiang Li, Mohamed A. El-Moselhy, Takashi Nakano, Akira Sawaguchi, S.C. Tyagi, Hiroshi Yano, Simona Pellacani, Akira Asai, Tadashi Shimizu, Yasushi Ishida, Toshihiko Yanagita, Miho Iwase, Masashi Tawa, Sabrina Malvagia, Masato Komai, Tomoyuki Nishizaki, Hiroko Akiyoshi, Tetsuro Shirasaka, Hongliang Zhang, Patricia N. Sidharta, Takashi Sato, Ohshima Etsuo, Hang Yuan, Takashi Shimosato, Motoki Miyama, Isao Tsuneyoshi, Takeshi Imamura, Ping Luo, Taomin Huang, S. Pushpakumar, Renrong Wu, Druck Reinhardt Druck Basel, N. Narayanan, Mohamed A. Morsy, F. Armaghan, Katsuaki Dan, Kaori Munakata, Kazuyoshi Hirota, Hideki Hasegawa, Ichiro Miki, Renzo Guerrini, Yuto Ueda, Kenji Watanabe, Tomio Okamura, Takeshi Kanno, S. Dalaklioglu-Tasatargil, Fumiyo Toyoshima-Aoyama, Ayman Geddawy, Anna Rosati, Giancarlo la Marca, Nian Liu, Yan Zeng, S. Givvimani
Publikováno v:
Pharmacology. 91:I-IV
Autor:
Kiyotaka Oshikawa, Keiichi I. Nakayama, Jun Kudoh, Mitsuru Matsumoto, Nobuyoshi Shimizu, Jukka Pitkänen, Shigetsugu Hatakeyama, Kyoko Tsurugaya, Vassilis Doucas, Pärt Peterson, Akemi Matsushima, Hiroko Akiyoshi, Yasuhiro Mouri, Daisuke Uchida
Publikováno v:
Journal of Biological Chemistry. 279:33984-33991
Autoimmune regulator (AIRE) is responsible for the development of organ-specific autoimmune disease in a monogenic fashion. Rare and low levels of tissue expression together with the lack of AIRE-expressing cell lines have hampered a detailed analysi
Autor:
Noriko Nagata, Makiko Oka, Tomoko Wada, Yutaka Nakaya, Toshihiro Toyoshima, Hiroko Akiyoshi, Yasuharu Niwa
Publikováno v:
Life Sciences. 67:1103-1109
Human chymase selectively converts big endothelin (ET)-1 to 31-amino-acid-length ET-1 [ET-1(1-31)]. In this study we examined effect of ET-1(1-31) on endothelial function. ET-1(1-31) evoked contraction in a concentration-dependent manner at >10 −8