Výsledky vyhledávání - "Hiroko, Matsushita"

Compound heterozygous ADAMTS9 variants in Joubert syndrome-related disorders without renal manifestation

Autor: Katsumi Hayakawa, Hirotomo Saitsu, Hiroko Matsushita, Takuya Hiraide, Sozo Okano, Mitsuhiro Kato, Mitsuko Nakashima

Publikováno v: Brain and Development. 44:161-165

Background Ciliopathies are the outcomes of defects of primary cilia structures and functions which cause multisystemic developmental disorders, such as polycystic kidney disease, nephronophthisis, retinitis pigmentosa, Joubert syndrome (JS), and JS-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c027a1854a2e077406d573caf5966a4
https://doi.org/10.1016/j.braindev.2021.10.004

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Comprehensive genetic analysis confers high diagnostic yield in 16 Japanese patients with corpus callosum anomalies

Publikováno v: Journal of human genetics. 66(11)

Corpus callosum anomalies (CCA) is a common congenital brain anomaly with various etiologies. Although one of the most important etiologies is genetic factors, the genetic background of CCA is heterogenous and diverse types of variants are likely to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceac93c67e6fb9057a6ef123f1c96ab1
https://pubmed.ncbi.nlm.nih.gov/33958710

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Athetotic and Spastic Cerebral Palsy: Anatomic Characterization Based on Diffusion-Tensor Imaging

Autor: Shoko Yoshida, Naoko Yoshida, Katsumi Hayakawa, Hiroko Matsushita, Mika Iwami, Toyoko Kanda, Souzo Okano, Susumu Mori, Kenichi Oishi, Yuriko Yamori, Haruyo Hirota

Publikováno v: Radiology. 260:511-520

To evaluate the anatomy of deep gray and white matter structures in children with athetotic cerebral palsy (CP) and those with spastic CP by using diffusion-tensor (DT) imaging and to investigate whether these types of CP have unique anatomic correla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501df925747c8d096246ed47b35a3476
https://doi.org/10.1148/radiol.11101783

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Effects of care giving environment on caregiver burden stress of family engaged in in-home medical care

Autor: Kazuhito Yokoyama, Hiroko Matsushita, Michiko Kurosawa, Yutaka Inaba, Mie Izumune

Publikováno v: Japanese Journal of Health and Human Ecology. 76:155-163

The purpose of the study was to clarify the effects of care environment on health status of caregivers engaged in at-home medical care for their family member. Twenty-eight female caregivers were surveyed three times, i. e. one week, one month, and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe993cc10da77ce29ce48451539cef0d
https://doi.org/10.3861/jshhe.76.155

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Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:5339-5345

Optimization of the lead 2a led to the identification of a novel diarylketoxime class of melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. Our focus was directed toward improvement of hERG activity and metabolic stability. The representa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4d7fb37b33c5d2a3dbe6fc37052a6d
https://doi.org/10.1016/j.bmcl.2009.07.132

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Chronic Intracerebroventricular Infusion of Nociceptin/Orphanin FQ Produces Body Weight Gain by Affecting Both Feeding and Energy Metabolism in Mice

Autor: Hisashi Ohta, Akio Kanatani, Hiroko Matsushita, Akane Ishihara, Hisashi Iwaasa, Takeshi Tanaka, Tetsuya Kanno, Satoshi Mashiko

Publikováno v: Endocrinology. 150:2668-2673

Nociceptin/orphanin FQ (N/OFQ), an endogenous ligand for opioid receptor-like 1 (ORL1), is involved in various central functions, such as pain, psychological stress, locomotor activity, learning and memory, and feeding regulation. Of these functions,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c99b928263caaf6c3a0639d292a43b4
https://doi.org/10.1210/en.2008-1515

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Effects of a Novel Y5 Antagonist in Obese Mice: Combination With Food Restriction or Sibutramine

Autor: Akio Kanatani, Lex H.T. Van der Ploeg, Akira Gomori, Toshiyuki Takahashi, Junko Ito, Akane Ishihara, Ryuichi Moriya, Hiroko Matsushita, Hidefumi Kitazawa, Satoshi Mashiko, Hisashi Iwaasa, Yuko Mitobe, Douglas J. MacNeil, Takehiro Fukami

Publikováno v: Obesity. 16:1510-1515

Objective: To further address the function of the Y5 receptor in energy homeostasis, we investigated the effects of a novel spironolactone Y5 antagonist in diet-induced obese (DIO) mice. Methods and Procedures: Male C57BL/6 or Npy5r−/− mice were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88837af7b9c8206207e0da799c89f340
https://doi.org/10.1038/oby.2008.223

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Novel carbohydrate-binding activity of bovine liver β-glucuronidase toward lactose/N-acetyllactosamine sequences

Autor: Tetsuko Kanamori, Nobuko Seno, Hiromi Sakagami, Hiroko Matsushita-Oikawa, Mayumi Komatsu, Isamu Matsumoto, Haruko Ogawa, Naoko Iida-Tanaka

Publikováno v: Glycobiology. 16:891-901

Beta-glucuronidase is a lysosomal enzyme that plays an essential role in normal turnover of glycosaminoglycans and remodeling of the extracellular matrix components in both physiological and inflammatory states. The regulation mechanisms of enzyme ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7eb29245ef0d47a1e9e0731ec14bdb
https://doi.org/10.1093/glycob/cwl016

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