Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Hiroki Toyoda"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Brain degenerations in sporadic Alzheimer’s disease (AD) are observed earliest in the locus coeruleus (LC), a population of noradrenergic neurons, in which hyperphosphorylated tau protein expression and β-amyloid (Aβ) accumulation begin. Along wi
Externí odkaz:
https://doaj.org/article/0aa32f321e2e4627809352cedbe74cc7
Autor:
Hajime Sato, Keitaro Satoh, Kazunori Nozaki, Misato Yugawa, Takafumi Kato, Hiroki Toyoda, Ayano Katagiri, Naoto Suda, Kazunori Adachi
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms, and it is associated with several prodromal non-motor symptoms, including an impaired sense of smell, taste and touch. We previously reported that bitter tast
Externí odkaz:
https://doaj.org/article/d0a9544948c14428a6a947205cf76fd7
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5266 (2024)
The muscle contraction during voluntary movement is controlled by activities of alpha- and gamma-motoneurons (αMNs and γMNs, respectively). In spite of the recent advances in research on molecular markers that can distinguish between αMNs and γMN
Externí odkaz:
https://doaj.org/article/de888d61d4bb4a3fb48bd89f05b17fda
Autor:
Hiroki Toyoda, Jonghwa Won, Wheedong Kim, Hayun Kim, Oscar Davy, Mitsuru Saito, Doyun Kim, Takuma Tanaka, Youngnam Kang, Seog Bae Oh
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Noradrenergic neurons in the locus coeruleus (LC) release noradrenaline (NA) that acts via volume transmission to activate extrasynaptic G-protein coupled receptors (GPCRs) in target cells throughout the brain. As the closest projection, the dorsal L
Externí odkaz:
https://doaj.org/article/8bcfbcd3be30405796881afc9db153a4
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 344 (2022)
Somatic expressions of either heteromeric TASK1/3 or homomeric TASK1/1 channels have been reported in various neurons, while expression of homomeric TASK3/3 channels has been re-ported only in dendrites. However, it is not known why homomeric TASK3/3
Externí odkaz:
https://doaj.org/article/a6aff21e1b6b492a979840c2631c4abd
Autor:
Hiroki Toyoda, Kohei Koga
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 34 (2021)
To find satisfactory treatment for nicotine addiction, synaptic and cellular mechanisms should be investigated comprehensively. Synaptic transmission, plasticity and intrinsic excitability in various brain regions are known to be altered by acute nic
Externí odkaz:
https://doaj.org/article/d3e02115d5a143849c39ec93ab7669d5
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 259 (2020)
The pesticide rotenone inhibits mitochondrial complex I and is thought to cause neurological disorders such as Parkinson’s disease and cognitive disorders. However, little is known about the effects of rotenone on conditioned taste aversion memory.
Externí odkaz:
https://doaj.org/article/7f0af3d6a9df4ddb9e5d6a2962d91205
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 563 (2020)
It is known that desensitization of GABAA receptor (GABAAR)-mediated currents is paradoxically correlated with the slowdown of their deactivation, i.e., resensitization. It has been shown that an upregulation of calcineurin enhances the desensitizati
Externí odkaz:
https://doaj.org/article/4b6910ca783e4b8d9d90936f6756533d
Autor:
Yasuhiro Kawasaki, Mitsuru Saito, Jonghwa Won, Jin Young Bae, Hajime Sato, Hiroki Toyoda, Eriko Kuramoto, Mikihiko Kogo, Takuma Tanaka, Takeshi Kaneko, Seog Bae Oh, Yong Chul Bae, Youngnam Kang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Glutamatergic dendritic EPSPs evoked in cortical pyramidal neurons are depressed by activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels expressed in dendritic spines. This depression has been attributed to shunting effect
Externí odkaz:
https://doaj.org/article/c8109dfdbd404636b6c2c58b669d4d9e
Autor:
Kayo Nishimura, Masahiro Ohta, Mitsuru Saito, Yukako Morita-Isogai, Hajime Sato, Eriko Kuramoto, Dong Xu Yin, Yoshinobu Maeda, Takeshi Kaneko, Takashi Yamashiro, Kenji Takada, Seog Bae Oh, Hiroki Toyoda, Youngnam Kang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
The muscle contraction during voluntary movement is regulated by activities of α- and γ-motoneurons (αMNs and γMNs, respectively). The tension of jaw-closing muscles can be finely tuned over a wide range. This excellent function is likely to be a
Externí odkaz:
https://doaj.org/article/a00cdf30374e43acb0f877cea95771dd