Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hiroki Shimogawa"'
Autor:
Yutaka Kondo, Yoshitaka Sekido, Jean-Pierre J. Issa, Toshihiko Wakabayashi, Seung U. Kim, Hideyuki Okano, Motonari Uesugi, Hiroki Shimogawa, Ichiro Takeuchi, Yuta Ishikawa, Satoru Takahashi, Shinya Sato, Keiko Shinjo, Akira Hatanaka, Fumiharu Ohka, Keisuke Katsushima, Motokazu Ito, Atsushi Natsume
PDF - 157KB, Figure S1. Characterization of GSCs. Figure S2. Significance of EZH2/PRC2 in GBMs and GSCs. Figure S3. ChIP-chip analysis and MCAM analysis in GSCs. Figure S4. Effects of Wnt1-KD and BMP5-overexpression in GSCs. Figure S5. Downregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e189c5fd111ab30bc30a63c660b56b6
https://doi.org/10.1158/0008-5472.22396394
https://doi.org/10.1158/0008-5472.22396394
Autor:
Kouhei Yamada, Motonari Uesugi, Lutfi Abu-Elheiga, Hiroki Shimogawa, Takashi Shirakawa, Shinji Kamisuki, Akira Kugimiya, Salih J. Wakil, Hea-Young Park Choo
Publikováno v:
Journal of Medicinal Chemistry. 54:4923-4927
Fatostatin, a recently discovered small molecule that inhibits activation of sterol regulatory element-binding protein (SREBP), blocks biosynthesis and accumulation of fat in obese mice. The present study synthesized and evaluated a series of fatosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811aa07e5b17d8707e4d868343a2076f
https://doi.org/10.1021/jm200304y
https://doi.org/10.1021/jm200304y
Autor:
Norio Nakatsuji, Kayoko Tsukita, Kazuhiro Aiba, Yasuyuki Asai, Gaku Murakami, Yuji Amagai, Haruhisa Inoue, Hiroki Shimogawa, Ryosuke Takahashi, Motonari Uesugi
Publikováno v:
SLAS Discovery. 16:405-414
Familial amyotrophic lateral sclerosis (fALS) accounts for 10% of ALS cases, and about 25% of fALS cases are due to mutations in superoxide dismutase 1 (SOD1). Mutant SOD1-mediated ALS is caused by a gain of toxic function of the mutant protein, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7536f6d1500dd982efc636f1df76e255
https://doi.org/10.1177/1087057110397888
https://doi.org/10.1177/1087057110397888
Autor:
Hiroki Shimogawa, Shinichi Sato, Qian Mao, Hideo Kigoshi, Shinji Kamisuki, Dongju Jung, Youngjoo Kwon, Motonari Uesugi
Publikováno v:
Journal of the American Chemical Society. 131:4774-4782
Naturally occurring transcription factors usually have two independent domains, a DNA-binding domain and an activation domain. In designing a synthetic small molecule that mimics a transcription factor, each of the two domains needs to be replaced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ca6c7edf10a80fe8cef0c4911a6fca
https://doi.org/10.1021/ja900669k
https://doi.org/10.1021/ja900669k
Autor:
Motonari Uesugi, Hiroki Shimogawa, Yongmun Choi, Jun Qin, Latha Ramdas, Wei Zhang, Koji Murakami
Publikováno v:
Chemistry & Biology. 13:241-249
SummaryInsulin-like growth factor 2 (IGF2) is a potent mitogen whose deregulation plays a role in developing liver, breast, and prostate cancers. Here, we take a small-molecule approach to investigate molecular pathways that modulate IGF2 signaling,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab3975949b8c270730fcd160149732b
https://doi.org/10.1016/j.chembiol.2005.12.011
https://doi.org/10.1016/j.chembiol.2005.12.011
Publikováno v:
Tetrahedron. 60:7067-7075
To obtain information on the chemical modification of biomolecules with jolkinolide D, a bioactive diterpenoid of plant origin, jolkinolide D pharmacophore was synthesized, and its reactivity toward amino acids, nucleosides, and DNA was investigated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43aa2a54a3b095772912fb9ace267eb1
https://doi.org/10.1016/j.tet.2003.08.080
https://doi.org/10.1016/j.tet.2003.08.080
Autor:
Shinichi Asada, Yongmun Choi, Youngjoo Kwon, Yoshinori Kawazoe, Hideo Kigoshi, Hiroki Shimogawa, Motonari Uesugi, Qian Mao
Publikováno v:
Journal of the American Chemical Society. 126:3461-3471
Development of synthetic molecules that provide external control over the transcription of a given gene represents a challenge in medicinal and bioorganic chemistry. Here we report design and analysis of wrenchnolol, a wrench-shaped synthetic molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ca1d41aed2c3e07764b55150a962873
https://doi.org/10.1021/ja038855+
https://doi.org/10.1021/ja038855+
Autor:
Yasuhisa Kimura, Eihachiro Kawase, Norio Nakatsuji, Di Mao, Hiroki Shimogawa, Kazumitsu Ueda, Nao Hirata, Bilon Khambu, Ting-Fang Kuo, Makoto Ojika, Motonari Uesugi
Publikováno v:
Journal of the American Chemical Society. 136(28)
One of the current obstacles to stem cell therapy is the tumorigenic potential of residual undifferentiated stem cells. The present study reports rediscovery of a synthetic derivative of okadaic acid, a marine polyether toxin, as a reagent that selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4987b3517c2d64088333f80809161c87
https://pubmed.ncbi.nlm.nih.gov/24992689
https://pubmed.ncbi.nlm.nih.gov/24992689
Publikováno v:
Tetrahedron Letters. 47:1409-1411
The trifluoroacetate salt of cinachyramine (1) was isolated from the Okinawan sponge Cinachyrella sp. This structure was determined by the spectroscopic analysis and the degradation under acidic conditions. Cinachyramine (1) is a novel alkaloid with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83165d55aba4473ca3ffd4737b6d370
https://doi.org/10.1016/j.tetlet.2005.12.087
https://doi.org/10.1016/j.tetlet.2005.12.087
Publikováno v:
Bulletin of the Chemical Society of Japan. 78:1345-1347
New 13-epi-neoverrucosane-type diterpenes 1 and 2 were isolated from the marine sponge Axinyssa tethyoides. Their structures were elucidated by 2D-NMR spectroscopy, the modified Mosher’s method, an...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8097ee821f3d256ac99e5e2325aa9d9
https://doi.org/10.1246/bcsj.78.1345
https://doi.org/10.1246/bcsj.78.1345