Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Hiroki Shima"'
Autor:
Akane Suda, Banlanjo Abdulaziz Umaru, Yui Yamamoto, Hiroki Shima, Yuriko Saiki, Yijun Pan, Liang Jin, Jiaqi Sun, Yi Ling Clare Low, Chitose Suzuki, Takaaki Abe, Kazuhiko Igarashi, Toru Furukawa, Yuji Owada, Yoshiteru Kagawa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Despite recent advances in science and medical technology, pancreatic cancer remains associated with high mortality rates due to aggressive growth and no early clinical sign as well as the unique resistance to anti-cancer chemotherapy. Curre
Externí odkaz:
https://doaj.org/article/b018f4c6e79b482e842d45f31a599d50
Autor:
Katsutaka Mitachi, Kyohei Ariake, Hiroki Shima, Satoko Sato, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Hideo Ohtsuka, Takashi Kamei, Kazuhiko Igarashi, Michiaki Unno
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The collagen gel droplet-embedded drug sensitivity test (CD-DST) was revealed to be useful for predicting the effect of S-1 adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PDAC). However, collection of an adequate number of PDAC
Externí odkaz:
https://doaj.org/article/fa83f9a72d394814885790e89c076786
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Nitrogen assimilation is an essential process that controls plant growth and development. Plant cells adjust the transcription of nitrogen assimilation genes through transcription factors (TFs) to acclimatize to changing nitrogen levels in nature. Ho
Externí odkaz:
https://doaj.org/article/cb2f98507adf44d5b4a12e797bb40a51
Autor:
Kyoko Ochiai, Hiroki Shima, Tsuyoshi Ikura, Marissa C. Franke, Evelyn P. Sievert, Roger Sciammas, Kazuhiko Igarashi
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100633- (2021)
Summary: Molecular-level understanding of plasma cell (PC) differentiation has been modeled using lipopolysaccharide (LPS) stimulation in vitro. However, this system does not involve the B-cell receptor (BCR)—a critical component of B cell biology.
Externí odkaz:
https://doaj.org/article/fc80430e7afc47888d26151c9fa9ea0f
Autor:
Yukie Suzuki, Tatsuyuki Takadate, Masamichi Mizuma, Hiroki Shima, Takashi Suzuki, Tomoyoshi Tachibana, Mitsuhiro Shimura, Tatsuo Hata, Masahiro Iseki, Kei Kawaguchi, Takeshi Aoki, Hiroki Hayashi, Takanori Morikawa, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Kazuhiko Igarashi, Michiaki Unno
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235904 (2020)
Pancreatic ductal adenocarcinoma is one of the most aggressive types of cancer. Certain proteins in the tumor microenvironment have attracted considerable attention owing to their association with tumor invasion and metastasis. Here, we used proteomi
Externí odkaz:
https://doaj.org/article/26f1324b580243e3bd261cfa7c71dd43
Autor:
Kyoko Ochiai, Haruka Kondo, Yasunobu Okamura, Hiroki Shima, Yuko Kurokochi, Kazumi Kimura, Ryo Funayama, Takeshi Nagashima, Keiko Nakayama, Katsuyuki Yui, Kengo Kinoshita, Kazuhiko Igarashi
Publikováno v:
Blood Advances, Vol 2, Iss 8, Pp 883-894 (2018)
Abstract: The transcription factor (TF) interferon regulatory factor-4 (IRF4) promotes both germinal center (GC) reactions and plasma cell (PC) differentiation by binding to alternative DNA motifs including AP-1-IRF composite elements, Ets-IRF compos
Externí odkaz:
https://doaj.org/article/42728ff5ba0f4e7f92ab49b24d031359
Autor:
Hiroki Shima, Mitsuyo Matsumoto, Yuma Ishigami, Masayuki Ebina, Akihiko Muto, Yuho Sato, Sayaka Kumagai, Kyoko Ochiai, Tsutomu Suzuki, Kazuhiko Igarashi
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3354-3363 (2017)
Summary: S-adenosylmethionine (SAM) is an important metabolite as a methyl-group donor in DNA and histone methylation, tuning regulation of gene expression. Appropriate intracellular SAM levels must be maintained, because methyltransferase reaction r
Externí odkaz:
https://doaj.org/article/5a7e6f07499a44caaf983f77c3e71719
Autor:
Yuki Miyazaki, Kazutaka Murayama, Ibrahim Fathi, Takehiro Imura, Youhei Yamagata, Kimiko Watanabe, Hiroshi Maeda, Akiko Inagaki, Yasuhiro Igarashi, Shigehito Miyagi, Hiroki Shima, Kazuhiko Igarashi, Takashi Kamei, Michiaki Unno, Masafumi Goto
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216136 (2019)
BackgroundOptimizing the collagenase G (ColG):collagenase H (ColH) ratio is a key strategy for achieving tailored donor-tissue specific islet isolation. Collagen V (Col V) and collagen III (Col III) are crucial target matrices of ColG and ColH, respe
Externí odkaz:
https://doaj.org/article/b75e932c6d3c4669ad00cc70fd81c633
Autor:
Ikuko Nakamae, Tsumoru Morimoto, Hiroki Shima, Masafumi Shionyu, Hisayo Fujiki, Noriko Yoneda-Kato, Takashi Yokoyama, Shigehiko Kanaya, Kiyomi Kakiuchi, Tsuyoshi Shirai, Edy Meiyanto, Jun-ya Kato
Publikováno v:
Molecules, Vol 24, Iss 22, p 4067 (2019)
Background: Curcumin has been shown to exert pleiotropic biological effects, including anti-tumorigenic activity. We previously showed that curcumin controls reactive oxygen species (ROS) levels through the ROS metabolic enzymes, to prevent tumor cel
Externí odkaz:
https://doaj.org/article/be5359af826141468328aa963c006989
Autor:
Daichi Iwasaki, Kayoko Hayashihara, Hiroki Shima, Mika Higashide, Masahiro Terasawa, Susan M Gasser, Miki Shinohara
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005942 (2016)
Because DNA double-strand breaks (DSBs) are one of the most cytotoxic DNA lesions and often cause genomic instability, precise repair of DSBs is vital for the maintenance of genomic stability. Xrs2/Nbs1 is a multi-functional regulatory subunit of the
Externí odkaz:
https://doaj.org/article/1d3eafe200024e5b84f5a933489297b4