Zobrazeno 1 - 10
of 344
pro vyhledávání: '"Hiroki Shima"'
Autor:
Akane Suda, Banlanjo Abdulaziz Umaru, Yui Yamamoto, Hiroki Shima, Yuriko Saiki, Yijun Pan, Liang Jin, Jiaqi Sun, Yi Ling Clare Low, Chitose Suzuki, Takaaki Abe, Kazuhiko Igarashi, Toru Furukawa, Yuji Owada, Yoshiteru Kagawa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Despite recent advances in science and medical technology, pancreatic cancer remains associated with high mortality rates due to aggressive growth and no early clinical sign as well as the unique resistance to anti-cancer chemotherapy. Curre
Externí odkaz:
https://doaj.org/article/b018f4c6e79b482e842d45f31a599d50
Autor:
Katsutaka Mitachi, Kyohei Ariake, Hiroki Shima, Satoko Sato, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Hideo Ohtsuka, Takashi Kamei, Kazuhiko Igarashi, Michiaki Unno
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The collagen gel droplet-embedded drug sensitivity test (CD-DST) was revealed to be useful for predicting the effect of S-1 adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PDAC). However, collection of an adequate number of PDAC
Externí odkaz:
https://doaj.org/article/fa83f9a72d394814885790e89c076786
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Nitrogen assimilation is an essential process that controls plant growth and development. Plant cells adjust the transcription of nitrogen assimilation genes through transcription factors (TFs) to acclimatize to changing nitrogen levels in nature. Ho
Externí odkaz:
https://doaj.org/article/cb2f98507adf44d5b4a12e797bb40a51
Autor:
Kyoko Ochiai, Hiroki Shima, Tsuyoshi Ikura, Marissa C. Franke, Evelyn P. Sievert, Roger Sciammas, Kazuhiko Igarashi
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100633- (2021)
Summary: Molecular-level understanding of plasma cell (PC) differentiation has been modeled using lipopolysaccharide (LPS) stimulation in vitro. However, this system does not involve the B-cell receptor (BCR)—a critical component of B cell biology.
Externí odkaz:
https://doaj.org/article/fc80430e7afc47888d26151c9fa9ea0f
Autor:
Masatoshi Ikeda, Hiroki Kato, Hiroki Shima, Mitsuyo Matsumoto, Eijiro Furukawa, Yan Yan, Ruiqi Liao, Jian Xu, Akihiko Muto, Tohru Fujiwara, Hideo Harigae, Emery H. Bresnick, Kazuhiko Igarashi
Publikováno v:
Exp Hematol
Although establishment and maintenance of mitochondria are essential for the production of massive amounts of heme in erythroblasts, mitochondria must be degraded upon terminal differentiation to red blood cells (RBCs), thus creating a biphasic regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a4ecf54b0a3419c2a68a0c493cb056
https://doi.org/10.1016/j.exphem.2022.11.007
https://doi.org/10.1016/j.exphem.2022.11.007
Autor:
Yukie Suzuki, Tatsuyuki Takadate, Masamichi Mizuma, Hiroki Shima, Takashi Suzuki, Tomoyoshi Tachibana, Mitsuhiro Shimura, Tatsuo Hata, Masahiro Iseki, Kei Kawaguchi, Takeshi Aoki, Hiroki Hayashi, Takanori Morikawa, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Kazuhiko Igarashi, Michiaki Unno
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235904 (2020)
Pancreatic ductal adenocarcinoma is one of the most aggressive types of cancer. Certain proteins in the tumor microenvironment have attracted considerable attention owing to their association with tumor invasion and metastasis. Here, we used proteomi
Externí odkaz:
https://doaj.org/article/26f1324b580243e3bd261cfa7c71dd43
Autor:
Kyoko Ochiai, Haruka Kondo, Yasunobu Okamura, Hiroki Shima, Yuko Kurokochi, Kazumi Kimura, Ryo Funayama, Takeshi Nagashima, Keiko Nakayama, Katsuyuki Yui, Kengo Kinoshita, Kazuhiko Igarashi
Publikováno v:
Blood Advances, Vol 2, Iss 8, Pp 883-894 (2018)
Abstract: The transcription factor (TF) interferon regulatory factor-4 (IRF4) promotes both germinal center (GC) reactions and plasma cell (PC) differentiation by binding to alternative DNA motifs including AP-1-IRF composite elements, Ets-IRF compos
Externí odkaz:
https://doaj.org/article/42728ff5ba0f4e7f92ab49b24d031359
Autor:
Hiroki Shima, Mitsuyo Matsumoto, Yuma Ishigami, Masayuki Ebina, Akihiko Muto, Yuho Sato, Sayaka Kumagai, Kyoko Ochiai, Tsutomu Suzuki, Kazuhiko Igarashi
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3354-3363 (2017)
Summary: S-adenosylmethionine (SAM) is an important metabolite as a methyl-group donor in DNA and histone methylation, tuning regulation of gene expression. Appropriate intracellular SAM levels must be maintained, because methyltransferase reaction r
Externí odkaz:
https://doaj.org/article/5a7e6f07499a44caaf983f77c3e71719
Autor:
Mizuki Sawata, Hiroki Shima, Kazutaka Murayama, Toshitaka Matsui, Kazuhiko Igarashi, Kazumasa Funabashi, Kenji Ite, Kenji Kizawa, Hidenari Takahara, Masaki Unno
Publikováno v:
ACS Omega. 7:28378-28387
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1db649ef93554249d0e7fd04ceeb926
https://doi.org/10.1021/acsomega.2c02972
https://doi.org/10.1021/acsomega.2c02972
Autor:
Takumi Kouketsu, Rina Monma, Yuri Miyairi, Shun Sawatsubashi, Hiroki Shima, Kazuhiko Igarashi, Akira Sugawara, Atsushi Yokoyama
Publikováno v:
Biochemical and Biophysical Research Communications. 615:81-87
Hepatocyte nuclear factor 4α (HNF4α) has essential roles in controlling the expression of a variety of genes involved in key metabolic pathways, including gluconeogenesis in the liver. The mechanistic and physiological significance of peroxisome pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28dadde854c511737a82c208c729f05f
https://doi.org/10.1016/j.bbrc.2022.04.133
https://doi.org/10.1016/j.bbrc.2022.04.133